TW200823216A - Combination therapies for rheumatoid arthritis - Google Patents

Info

Publication number

TW200823216A

TW200823216A TW096132844A TW96132844A TW200823216A TW 200823216 A TW200823216 A TW 200823216A TW 096132844 A TW096132844 A TW 096132844A TW 96132844 A TW96132844 A TW 96132844A TW 200823216 A TW200823216 A TW 200823216A

Authority

TW

Taiwan

Prior art keywords

alkyl

crc6

group

methyl

cvc6

Prior art date

2006-09-05

Links

• Espacenet
• Global Dossier
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• 238000002648 combination therapy Methods 0.000 title claims abstract description 24
• 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract description 13
• 150000003839 salts Chemical class 0.000 claims abstract description 71
• 229940122245 Janus kinase inhibitor Drugs 0.000 claims abstract description 41
• 238000011282 treatment Methods 0.000 claims abstract description 39
• 239000003435 antirheumatic agent Substances 0.000 claims abstract description 38
• 229940124346 antiarthritic agent Drugs 0.000 claims abstract description 35
• 125000000217 alkyl group Chemical group 0.000 claims description 327
• 150000001875 compounds Chemical class 0.000 claims description 193
• -1 hydroxy, amino Chemical group 0.000 claims description 117
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 74
• 125000003545 alkoxy group Chemical group 0.000 claims description 73
• 150000001412 amines Chemical class 0.000 claims description 52
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 52
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 50
• XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 46
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 46
• 125000003282 alkyl amino group Chemical group 0.000 claims description 45
• 239000003814 drug Substances 0.000 claims description 39
• CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 claims description 38
• 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 37
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 34
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 32
• 239000001257 hydrogen Substances 0.000 claims description 30
• 229910052739 hydrogen Inorganic materials 0.000 claims description 30
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 28
• 125000003277 amino group Chemical group 0.000 claims description 26
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 25
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 25
• 125000003118 aryl group Chemical group 0.000 claims description 24
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 22
• 239000007789 gas Substances 0.000 claims description 22
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
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• 229910052736 halogen Inorganic materials 0.000 claims description 17
• 125000001072 heteroaryl group Chemical group 0.000 claims description 17
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 16
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 16
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• 238000002360 preparation method Methods 0.000 claims description 11
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• 239000000126 substance Substances 0.000 claims description 10
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• VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims description 5
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• 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims description 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
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• 239000004575 stone Substances 0.000 claims description 5
• 238000006467 substitution reaction Methods 0.000 claims description 5
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 4
• 125000004414 alkyl thio group Chemical group 0.000 claims description 4
• 125000005110 aryl thio group Chemical group 0.000 claims description 4
• 125000000000 cycloalkoxy group Chemical group 0.000 claims description 4
• 150000002431 hydrogen Chemical class 0.000 claims description 4
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 4
• 229960001639 penicillamine Drugs 0.000 claims description 4
• 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
• 235000011152 sodium sulphate Nutrition 0.000 claims description 4
• JJTNLWSCFYERCK-UHFFFAOYSA-N 7h-pyrrolo[2,3-d]pyrimidine Chemical compound N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 claims description 3
• XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 3
• 229930105110 Cyclosporin A Natural products 0.000 claims description 3
• 102100037060 Forkhead box protein D3 Human genes 0.000 claims description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
• 101001029308 Homo sapiens Forkhead box protein D3 Proteins 0.000 claims description 3
• XEIPQVVAVOUIOP-UHFFFAOYSA-N [Au]=S Chemical compound [Au]=S XEIPQVVAVOUIOP-UHFFFAOYSA-N 0.000 claims description 3
• QLDHWVVRQCGZLE-UHFFFAOYSA-N acetyl cyanide Chemical compound CC(=O)C#N QLDHWVVRQCGZLE-UHFFFAOYSA-N 0.000 claims description 3
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• 125000001769 aryl amino group Chemical group 0.000 claims description 3
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