TW200801190A - Regulators of protein misfolding and aggregation and methods of using the same - Google Patents
Regulators of protein misfolding and aggregation and methods of using the sameInfo
- Publication number
- TW200801190A TW200801190A TW095131221A TW95131221A TW200801190A TW 200801190 A TW200801190 A TW 200801190A TW 095131221 A TW095131221 A TW 095131221A TW 95131221 A TW95131221 A TW 95131221A TW 200801190 A TW200801190 A TW 200801190A
- Authority
- TW
- Taiwan
- Prior art keywords
- aggregation
- protein
- alpha
- synuclein
- genes
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 230000002776 aggregation Effects 0.000 title abstract 3
- 238000004220 aggregation Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000004845 protein aggregation Effects 0.000 abstract 4
- 102000003802 alpha-Synuclein Human genes 0.000 abstract 3
- 108090000185 alpha-Synuclein Proteins 0.000 abstract 3
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 230000002018 overexpression Effects 0.000 abstract 2
- 101710138657 Neurotoxin Proteins 0.000 abstract 1
- 108091030071 RNAI Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000006778 dopaminergic neuroprotection Effects 0.000 abstract 1
- 238000009510 drug design Methods 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 239000002581 neurotoxin Substances 0.000 abstract 1
- 231100000618 neurotoxin Toxicity 0.000 abstract 1
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after exposure to the neurotoxin 6-OHDA or overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73876105P | 2005-11-21 | 2005-11-21 | |
| US74991005P | 2005-12-12 | 2005-12-12 | |
| PCT/US2006/007002 WO2006091964A2 (en) | 2005-02-25 | 2006-02-27 | Regulators of protein misfolding and aggregation and methods of using the same |
| US11/364,612 US20070204352A1 (en) | 2005-02-25 | 2006-02-27 | Regulators of protein misfolding and aggregation and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200801190A true TW200801190A (en) | 2008-01-01 |
Family
ID=44764972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095131221A TW200801190A (en) | 2005-11-21 | 2006-08-24 | Regulators of protein misfolding and aggregation and methods of using the same |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW200801190A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI800009B (en) * | 2015-07-15 | 2023-04-21 | 美商蓋斯特維炫股份有限公司 | Device for detecting misfolded proteins and methods of use thereof |
-
2006
- 2006-08-24 TW TW095131221A patent/TW200801190A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI800009B (en) * | 2015-07-15 | 2023-04-21 | 美商蓋斯特維炫股份有限公司 | Device for detecting misfolded proteins and methods of use thereof |
| TWI856560B (en) * | 2015-07-15 | 2024-09-21 | 美商蓋斯特維炫股份有限公司 | Device for detecting misfolded proteins and methods of use thereof |
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