TW200800989A - Pyrrolopyridine kinase inhibiting compounds - Google Patents
Pyrrolopyridine kinase inhibiting compoundsInfo
- Publication number
- TW200800989A TW200800989A TW095145567A TW95145567A TW200800989A TW 200800989 A TW200800989 A TW 200800989A TW 095145567 A TW095145567 A TW 095145567A TW 95145567 A TW95145567 A TW 95145567A TW 200800989 A TW200800989 A TW 200800989A
- Authority
- TW
- Taiwan
- Prior art keywords
- inhibiting compounds
- kinase inhibiting
- pyrrolopyridine
- pyrrolopyridine kinase
- prk2
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 102000004657 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Human genes 0.000 abstract 1
- 108010003721 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Proteins 0.000 abstract 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 abstract 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 abstract 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 abstract 1
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 abstract 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 abstract 1
- 101000935548 Homo sapiens Cytoplasmic tyrosine-protein kinase BMX Proteins 0.000 abstract 1
- 101000691459 Homo sapiens Serine/threonine-protein kinase N2 Proteins 0.000 abstract 1
- 101000864800 Homo sapiens Serine/threonine-protein kinase Sgk1 Proteins 0.000 abstract 1
- 101150028321 Lck gene Proteins 0.000 abstract 1
- 101150100676 Map2k1 gene Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001788 Proto-Oncogene Proteins c-raf Human genes 0.000 abstract 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 abstract 1
- 101150001535 SRC gene Proteins 0.000 abstract 1
- 101001117144 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial Proteins 0.000 abstract 1
- 102100026180 Serine/threonine-protein kinase N2 Human genes 0.000 abstract 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74811005P | 2005-12-07 | 2005-12-07 | |
| US86053106P | 2006-11-22 | 2006-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200800989A true TW200800989A (en) | 2008-01-01 |
Family
ID=37834178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095145567A TW200800989A (en) | 2005-12-07 | 2006-12-06 | Pyrrolopyridine kinase inhibiting compounds |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070129364A1 (zh) |
| EP (1) | EP1963320A1 (zh) |
| JP (1) | JP2009531274A (zh) |
| AR (1) | AR056886A1 (zh) |
| TW (1) | TW200800989A (zh) |
| WO (1) | WO2007067537A1 (zh) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2222639A1 (en) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
| AU2009262199B2 (en) | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| JP2011530511A (ja) * | 2008-08-05 | 2011-12-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療用化合物 |
| DE102008052943A1 (de) | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | Azaindolderivate |
| JP2012509342A (ja) * | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| JP2012517971A (ja) * | 2009-02-13 | 2012-08-09 | フォーヴィア・ファーマシューティカルズ | キナーゼ阻害薬としての［１，２，４］トリアゾロ［１，５−ａ］ピリジン類 |
| AR078411A1 (es) * | 2009-05-07 | 2011-11-09 | Lilly Co Eli | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende |
| WO2011111880A1 (ko) * | 2010-03-08 | 2011-09-15 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
| WO2011112666A1 (en) | 2010-03-09 | 2011-09-15 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| JP2013526543A (ja) * | 2010-05-12 | 2013-06-24 | アッヴィ・インコーポレイテッド | ピロロピリジン系およびピロロピリミジン系キナーゼ阻害薬 |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| JP2013526570A (ja) | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 縮合二環式キナーゼ阻害剤 |
| US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
| CN103732596B (zh) * | 2011-07-08 | 2016-06-01 | 诺华股份有限公司 | 吡咯并嘧啶衍生物 |
| ES2567552T3 (es) * | 2012-01-30 | 2016-04-25 | Cephalon, Inc. | Imidazo [4,5-b] derivados de piridina como los moduladores ALK y JAK para el tratamiento de trastornos proliferativos |
| CA2869954C (en) | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
| DK2925757T3 (en) | 2012-11-19 | 2018-01-15 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2015085482A1 (en) * | 2013-12-10 | 2015-06-18 | Novartis Ag | Egfr inhibitor forms |
| EP3200786B1 (en) * | 2014-10-03 | 2019-08-28 | Novartis AG | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| WO2018055316A1 (fr) | 2016-09-26 | 2018-03-29 | Centre National De La Recherche Scientifique | Composes pour leur utilisation en imagerie et notamment pour le diagnostic de maladies neuro-degeneratives |
| GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
| CN111566102B (zh) | 2017-10-18 | 2023-09-08 | 缆图药品公司 | 作为激活素受体样激酶抑制剂的取代的吡咯并吡啶 |
| WO2019142128A1 (en) * | 2018-01-18 | 2019-07-25 | Integral Biosciences Private Limited | Dual inhibitors of alk5 and p38α map kinase |
| EP3897630B1 (en) | 2018-12-21 | 2024-01-10 | Celgene Corporation | Thienopyridine inhibitors of ripk2 |
| CN115515579B (zh) * | 2020-02-05 | 2025-09-30 | 洛克菲勒大学 | 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法 |
| CN113582988B (zh) * | 2020-04-30 | 2025-09-09 | 正大天晴药业集团股份有限公司 | 吡啶并环类化合物及其医药用途 |
| CN113666934B (zh) * | 2021-07-28 | 2023-06-23 | 北京深度制耀科技有限公司 | Cdk9激酶抑制剂 |
| US20240343726A1 (en) * | 2021-08-02 | 2024-10-17 | The Rockefeller University | Pyrrolopyridine-3- and 4-carboxamide compositions and methods for cellular proliferation |
| WO2024114814A1 (en) * | 2022-12-02 | 2024-06-06 | Onquality Pharmaceuticals China Ltd | Jak inhibitors, pharmaceutical compositions, and therapeutic applications |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241146T3 (es) * | 1997-08-05 | 2005-10-16 | Pfizer Products Inc. | 4-aminopirrol(3,2-d)pirimidinas como antagonistas del receptor del neuropeptido y. |
| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| IL150388A0 (en) * | 1999-12-24 | 2002-12-01 | Aventis Pharma Ltd | Azaindoles |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| AU2003214412A1 (en) * | 2002-03-28 | 2003-10-13 | Eisai R & D Management Co., Ltd. | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders |
| UA78999C2 (en) * | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| US7058237B2 (en) * | 2002-06-28 | 2006-06-06 | Microsoft Corporation | Real-time wide-angle image correction system and method for computer image viewing |
| TW200403243A (en) * | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| US20050288299A1 (en) * | 2002-10-09 | 2005-12-29 | Mavunkel Babu J | Azaindole derivatives as inhibitors of p38 kinase |
| US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| CA2575808A1 (en) * | 2004-08-02 | 2006-02-16 | Osi Pharmaceuticals, Inc. | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
-
2006
- 2006-12-05 JP JP2008544438A patent/JP2009531274A/ja not_active Withdrawn
- 2006-12-05 WO PCT/US2006/046391 patent/WO2007067537A1/en not_active Ceased
- 2006-12-05 US US11/634,003 patent/US20070129364A1/en not_active Abandoned
- 2006-12-05 EP EP06839003A patent/EP1963320A1/en not_active Withdrawn
- 2006-12-06 TW TW095145567A patent/TW200800989A/zh unknown
- 2006-12-06 AR ARP060105394A patent/AR056886A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR056886A1 (es) | 2007-10-31 |
| WO2007067537A1 (en) | 2007-06-14 |
| US20070129364A1 (en) | 2007-06-07 |
| EP1963320A1 (en) | 2008-09-03 |
| JP2009531274A (ja) | 2009-09-03 |
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