TW200806625A - Therapeutic compounds - Google Patents

Therapeutic compounds Download PDF

Info

Publication number: TW200806625A
Authority: TW; Taiwan
Prior art keywords: group; alkyl; amine; alkoxy; compound
Prior art date: 2006-05-26

Application number

TW096117988A

Other languages

English (en)

Chinese (zh)

Inventor

Yun-Xing Cheng

Miroslaw Tomaszewski

Hua Yang

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-26

Filing date

2007-05-21

Publication date

2008-02-01

2007-05-21 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-02-01 Publication of TW200806625A publication Critical patent/TW200806625A/zh

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 112
230000001225 therapeutic effect Effects 0.000 title claims description 5
150000003839 salts Chemical class 0.000 claims abstract description 17
-1 acetoxy, hydroxy Chemical group 0.000 claims description 151
125000000217 alkyl group Chemical group 0.000 claims description 130
238000000034 method Methods 0.000 claims description 71
125000003545 alkoxy group Chemical group 0.000 claims description 45
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 45
239000000203 mixture Substances 0.000 claims description 44
150000001412 amines Chemical class 0.000 claims description 43
125000003282 alkyl amino group Chemical group 0.000 claims description 25
125000001072 heteroaryl group Chemical group 0.000 claims description 24
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
125000000753 cycloalkyl group Chemical group 0.000 claims description 23
229910052736 halogen Inorganic materials 0.000 claims description 23
150000002367 halogens Chemical class 0.000 claims description 23
125000001424 substituent group Chemical group 0.000 claims description 21
238000011282 treatment Methods 0.000 claims description 21
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 20
125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 19
125000003277 amino group Chemical group 0.000 claims description 18
125000003118 aryl group Chemical group 0.000 claims description 18
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
125000003342 alkenyl group Chemical group 0.000 claims description 17
239000001257 hydrogen Substances 0.000 claims description 16
229910052739 hydrogen Inorganic materials 0.000 claims description 16
150000003857 carboxamides Chemical class 0.000 claims description 15
239000003814 drug Substances 0.000 claims description 14
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 12
238000004519 manufacturing process Methods 0.000 claims description 12
125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
244000269722 Thea sinensis Species 0.000 claims description 10
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
208000018522 Gastrointestinal disease Diseases 0.000 claims description 9
201000010099 disease Diseases 0.000 claims description 9
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
206010036790 Productive cough Diseases 0.000 claims description 8
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
210000003802 sputum Anatomy 0.000 claims description 8
208000024794 sputum Diseases 0.000 claims description 8
GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims description 7
125000002757 morpholinyl group Chemical group 0.000 claims description 7
229910052757 nitrogen Inorganic materials 0.000 claims description 7
150000002923 oximes Chemical class 0.000 claims description 7
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 7
125000003396 thiol group Chemical class [H]S* 0.000 claims description 7
241001465754 Metazoa Species 0.000 claims description 6
150000003973 alkyl amines Chemical class 0.000 claims description 6
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
239000003795 chemical substances by application Substances 0.000 claims description 6
125000004093 cyano group Chemical group *C#N 0.000 claims description 6
125000000392 cycloalkenyl group Chemical group 0.000 claims description 6
125000001041 indolyl group Chemical group 0.000 claims description 6
239000001301 oxygen Substances 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 6
239000002689 soil Substances 0.000 claims description 6
125000003554 tetrahydropyrrolyl group Chemical group 0.000 claims description 6
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 5
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
125000005129 aryl carbonyl group Chemical group 0.000 claims description 5
150000002431 hydrogen Chemical class 0.000 claims description 5
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
125000004076 pyridyl group Chemical group 0.000 claims description 5
229910052707 ruthenium Inorganic materials 0.000 claims description 5
DFOCUWZXJBAUSQ-UHFFFAOYSA-N Berbamine Natural products O1C(C(=CC=2)O)=CC=2CC(C=23)N(C)CCC3=CC(OC)=C(OC)C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C1C=C2 DFOCUWZXJBAUSQ-UHFFFAOYSA-N 0.000 claims description 4
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
125000006612 decyloxy group Chemical group 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
GXHFUVWIGNLZSC-UHFFFAOYSA-N meldrum's acid Chemical class CC1(C)OC(=O)CC(=O)O1 GXHFUVWIGNLZSC-UHFFFAOYSA-N 0.000 claims description 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 claims description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
125000000033 alkoxyamino group Chemical group 0.000 claims description 3
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
229910052794 bromium Inorganic materials 0.000 claims description 3
125000001309 chloro group Chemical group Cl* 0.000 claims description 3
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
125000004663 dialkyl amino group Chemical group 0.000 claims description 3
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 3
230000000968 intestinal effect Effects 0.000 claims description 3
PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 claims description 3
125000001624 naphthyl group Chemical group 0.000 claims description 3
229910021653 sulphate ion Inorganic materials 0.000 claims description 3
208000011580 syndromic disease Diseases 0.000 claims description 3
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 claims description 2
FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 2
229960000623 carbamazepine Drugs 0.000 claims description 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
229910052801 chlorine Inorganic materials 0.000 claims description 2
229910052731 fluorine Inorganic materials 0.000 claims description 2
210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
125000004404 heteroalkyl group Chemical group 0.000 claims description 2
AVXURJPOCDRRFD-UHFFFAOYSA-N hydroxylamine group Chemical group NO AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 2
229910052747 lanthanoid Inorganic materials 0.000 claims description 2
150000002602 lanthanoids Chemical class 0.000 claims description 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
DFOCUWZXJBAUSQ-URLMMPGGSA-N Berbamine Chemical compound C([C@@H]1N(C)CCC=2C=C(C(OC=3C(OC)=C(OC)C=C4CCN(C)[C@@H](C=34)CC=3C=C(C(=CC=3)O)O3)=CC=21)OC)C1=CC=C3C=C1 DFOCUWZXJBAUSQ-URLMMPGGSA-N 0.000 claims 3
241000894007 species Species 0.000 claims 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
241000196324 Embryophyta Species 0.000 claims 2
150000001335 aliphatic alkanes Chemical class 0.000 claims 2
229960001716 benzalkonium Drugs 0.000 claims 2
IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical compound C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
GZVHEAJQGPRDLQ-UHFFFAOYSA-N 6-phenyl-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(C=2C=CC=CC=2)=N1 GZVHEAJQGPRDLQ-UHFFFAOYSA-N 0.000 claims 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 1
125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
244000166124 Eucalyptus globulus Species 0.000 claims 1
206010062717 Increased upper airway secretion Diseases 0.000 claims 1
VBTPRWXFCXZKPQ-UHFFFAOYSA-N [O].NN Chemical compound [O].NN VBTPRWXFCXZKPQ-UHFFFAOYSA-N 0.000 claims 1
125000003710 aryl alkyl group Chemical group 0.000 claims 1
125000001769 aryl amino group Chemical group 0.000 claims 1
CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims 1
125000001246 bromo group Chemical group Br* 0.000 claims 1
150000001924 cycloalkanes Chemical class 0.000 claims 1
QECQLMGRLZYSEW-UHFFFAOYSA-N decoxybenzene Chemical compound CCCCCCCCCCOC1=CC=CC=C1 QECQLMGRLZYSEW-UHFFFAOYSA-N 0.000 claims 1
238000010586 diagram Methods 0.000 claims 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
125000005567 fluorenylene group Chemical group 0.000 claims 1
239000007789 gas Substances 0.000 claims 1
125000005843 halogen group Chemical group 0.000 claims 1
125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
FJDUDHYHRVPMJZ-UHFFFAOYSA-N nonan-1-amine Chemical compound CCCCCCCCCN FJDUDHYHRVPMJZ-UHFFFAOYSA-N 0.000 claims 1
208000026435 phlegm Diseases 0.000 claims 1
208000019553 vascular disease Diseases 0.000 claims 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
208000002193 Pain Diseases 0.000 abstract description 20
230000036407 pain Effects 0.000 abstract description 18
238000002560 therapeutic procedure Methods 0.000 abstract description 9
239000008194 pharmaceutical composition Substances 0.000 abstract description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 130
235000019439 ethyl acetate Nutrition 0.000 description 66
238000002360 preparation method Methods 0.000 description 43
239000002585 base Substances 0.000 description 39
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 36
239000007787 solid Substances 0.000 description 36
238000005481 NMR spectroscopy Methods 0.000 description 33
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 32
239000000243 solution Substances 0.000 description 27
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 26
150000002576 ketones Chemical class 0.000 description 25
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101150041968 CDC13 gene Proteins 0.000 description 11
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238000005160 1H NMR spectroscopy Methods 0.000 description 10
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238000003818 flash chromatography Methods 0.000 description 9
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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
LJPZHJUSICYOIX-UHFFFAOYSA-N quinolizidine Chemical compound C1CCCC2CCCCN21 LJPZHJUSICYOIX-UHFFFAOYSA-N 0.000 description 1
210000003370 receptor cell Anatomy 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
YBCAZPLXEGKKFM-UHFFFAOYSA-K ruthenium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Ru+3] YBCAZPLXEGKKFM-UHFFFAOYSA-K 0.000 description 1
230000036280 sedation Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical class [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
210000005070 sphincter Anatomy 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
201000009032 substance abuse Diseases 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium group Chemical group [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
RQCNHUCCQJMSRG-UHFFFAOYSA-N tert-butyl piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1 RQCNHUCCQJMSRG-UHFFFAOYSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
125000006173 tetrahydropyranylmethyl group Chemical group 0.000 description 1
125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 description 1
RMOGKAAKEOSOEB-UHFFFAOYSA-N tetrazol-1-ylmethanamine Chemical compound NCN1C=NN=N1 RMOGKAAKEOSOEB-UHFFFAOYSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229940071127 thioglycolate Drugs 0.000 description 1
CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
239000001585 thymus vulgaris Substances 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000009529 traumatic brain injury Effects 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
HQVHOQAKMCMIIM-UHFFFAOYSA-N win 55,212-2 Chemical compound C=12N3C(C)=C(C(=O)C=4C5=CC=CC=C5C=CC=4)C2=CC=CC=1OCC3CN1CCOCC1 HQVHOQAKMCMIIM-UHFFFAOYSA-N 0.000 description 1
239000002023 wood Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW096117988A 2006-05-26 2007-05-21 Therapeutic compounds TW200806625A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US80324206P	2006-05-26	2006-05-26

Publications (1)

Publication Number	Publication Date
TW200806625A true TW200806625A (en)	2008-02-01

Family

ID=38778884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW096117988A TW200806625A (en)	2006-05-26	2007-05-21	Therapeutic compounds

Country Status (8)

Country	Link
EP (1)	EP2029535A1 (fr)
JP (1)	JP2009538296A (fr)
CN (1)	CN101495450A (fr)
AR (1)	AR061111A1 (fr)
CL (1)	CL2007001517A1 (fr)
TW (1)	TW200806625A (fr)
UY (1)	UY30363A1 (fr)
WO (1)	WO2007139464A1 (fr)

Families Citing this family (10)

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Publication number	Priority date	Publication date	Assignee	Title
EP2025674A1 (fr)	2007-08-15	2009-02-18	sanofi-aventis	Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
BRPI0922180A2 (pt) *	2008-12-08	2015-12-29	Sirtris Pharmaceuticals Inc	insoindolinona e análogos correlatos como moduladores de sirtuína
WO2012058133A1 (fr) *	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	Composés d'isoindolinone utiles comme inhibiteurs de pde 10
US9938269B2 (en)	2011-06-30	2018-04-10	Abbvie Inc.	Inhibitor compounds of phosphodiesterase type 10A
JP6211509B2 (ja)	2012-03-02	2017-10-11	武田薬品工業株式会社	複素環化合物およびその用途
US9777005B2 (en)	2012-11-19	2017-10-03	Takeda Pharmaceutical Company Limited	Bicyclic heterocyclic compound containing a substituted pyrrole ring
PL3134386T3 (pl)	2014-04-23	2020-11-16	Takeda Pharmaceutical Company Limited	Pochodne izoindolin-1-onu jako dodatnia aktywność allosterycznego modulatora cholinergicznego receptora muskarynowego m1 do leczenia choroby alzheimera
EP3144308B1 (fr)	2014-05-16	2020-06-24	Takeda Pharmaceutical Company Limited	Composé hétérocyclique contenant de l'azote
KR101846475B1 (ko)	2015-04-27	2018-04-09	주식회사 녹십자	TNIK, IKKε 및 TBK1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물
US20240076291A1 (en) *	2020-11-24	2024-03-07	Merck Sharp & Dohme Llc	Modified isoindolinones as glucosylceramide synthase inhibitors

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Publication number	Priority date	Publication date	Assignee	Title
US20030045552A1 (en) *	2000-12-27	2003-03-06	Robarge Michael J.	Isoindole-imide compounds, compositions, and uses thereof
DE10134482A1 (de) *	2001-07-16	2003-01-30	Bayer Ag	Substituierte Isoindole und ihre Verwendung
DE10137163A1 (de) *	2001-07-30	2003-02-13	Bayer Ag	Substituierte Isoindole und ihre Verwendung
US7405237B2 (en) *	2004-07-28	2008-07-29	Celgene Corporation	Isoindoline compounds and methods of their use
US7244759B2 (en) *	2004-07-28	2007-07-17	Celgene Corporation	Isoindoline compounds and methods of making and using the same

2007
- 2007-05-21 TW TW096117988A patent/TW200806625A/zh unknown
- 2007-05-23 AR ARP070102233A patent/AR061111A1/es not_active Application Discontinuation
- 2007-05-24 WO PCT/SE2007/000503 patent/WO2007139464A1/fr not_active Ceased
- 2007-05-24 UY UY30363A patent/UY30363A1/es not_active Application Discontinuation
- 2007-05-24 EP EP07748167A patent/EP2029535A1/fr not_active Withdrawn
- 2007-05-24 JP JP2009511980A patent/JP2009538296A/ja active Pending
- 2007-05-24 CN CNA2007800284618A patent/CN101495450A/zh active Pending
- 2007-05-25 CL CL2007001517A patent/CL2007001517A1/es unknown

Also Published As

Publication number	Publication date
CN101495450A (zh)	2009-07-29
CL2007001517A1 (es)	2008-01-25
EP2029535A1 (fr)	2009-03-04
AR061111A1 (es)	2008-08-06
WO2007139464A1 (fr)	2007-12-06
UY30363A1 (es)	2008-01-02
JP2009538296A (ja)	2009-11-05

Publication	Publication Date	Title
TW200806625A (en)	2008-02-01	Therapeutic compounds
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RU2667907C2 (ru)	2018-09-25	ИНГИБИРУЮЩЕЕ Trk СОЕДИНЕНИЕ
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TW200916458A (en)	2009-04-16	Heterocyclic compounds and methods of use thereof
TW200908963A (en)	2009-03-01	Novel compounds
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TW200521117A (en)	2005-07-01	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TWI285638B (en)	2007-08-21	Novel compounds
JP2010514672A (ja)	2010-05-06	Ｃｒｆアンタゴニスト活性を有する縮合複素環化合物