TW200730512A - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- TW200730512A TW200730512A TW095144144A TW95144144A TW200730512A TW 200730512 A TW200730512 A TW 200730512A TW 095144144 A TW095144144 A TW 095144144A TW 95144144 A TW95144144 A TW 95144144A TW 200730512 A TW200730512 A TW 200730512A
- Authority
- TW
- Taiwan
- Prior art keywords
- novel compounds
- phenylsulfonamides
- pyrazinyl
- fluoro
- therapy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- KDXZOTYTDLCBAR-UHFFFAOYSA-N n-(3-fluoropyrazin-2-yl)benzenesulfonamide Chemical class FC1=NC=CN=C1NS(=O)(=O)C1=CC=CC=C1 KDXZOTYTDLCBAR-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0502733 | 2005-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200730512A true TW200730512A (en) | 2007-08-16 |
Family
ID=38163190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095144144A TW200730512A (en) | 2005-12-12 | 2006-11-29 | Novel compounds |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20080293742A1 (zh) |
| EP (1) | EP1968951B1 (zh) |
| JP (1) | JP2009519332A (zh) |
| KR (1) | KR20080091139A (zh) |
| CN (1) | CN101370793B (zh) |
| AR (1) | AR058319A1 (zh) |
| AT (1) | ATE513819T1 (zh) |
| AU (1) | AU2006325573A1 (zh) |
| BR (1) | BRPI0619602A2 (zh) |
| CA (1) | CA2631342A1 (zh) |
| CL (1) | CL2006003449A1 (zh) |
| EC (1) | ECSP088603A (zh) |
| ES (1) | ES2366807T3 (zh) |
| IL (1) | IL191761A0 (zh) |
| NO (1) | NO20083070L (zh) |
| RU (1) | RU2008122401A (zh) |
| TW (1) | TW200730512A (zh) |
| UY (1) | UY29999A1 (zh) |
| WO (1) | WO2007069978A1 (zh) |
| ZA (1) | ZA200804921B (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI328007B (en) * | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
| PE20120810A1 (es) * | 2009-04-22 | 2012-07-08 | Axikin Pharmaceuticals Inc | Compuestos derivados de 5-ciano-2-(feniltio)bencensulfonamida como antagonistas de ccr3 |
| PL3041506T3 (pl) * | 2013-09-02 | 2023-05-15 | The University Of Melbourne | Sposób leczenia |
| CN104402890A (zh) * | 2014-11-10 | 2015-03-11 | 常州大学 | 一种制备五氟磺草胺的方法 |
| CN104447756A (zh) * | 2014-11-10 | 2015-03-25 | 常州大学 | 一种五氟磺草胺中间体的制备方法 |
| AU2018360766B2 (en) | 2017-11-06 | 2024-09-19 | Rapt Therapeutics, Inc. | Anticancer agents |
| CN110028501B (zh) | 2018-01-12 | 2022-02-22 | 迈德欣国际有限公司 | 化合物及其制备方法和用途 |
| CN108929279A (zh) * | 2018-07-27 | 2018-12-04 | 同济大学 | 一种含氟氨基吡嗪类化合物及其制备方法与应用 |
| CN113893220A (zh) * | 2020-07-07 | 2022-01-07 | 迈德欣国际有限公司 | 鼻粘膜给药剂型和其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB928151A (en) * | 1959-07-14 | 1963-06-06 | Farmaceutici Italia | Pyrazine derivatives |
| US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| KR19990082463A (ko) | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체 |
| AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| US6638937B2 (en) * | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EP1289952A1 (en) | 2000-05-31 | 2003-03-12 | AstraZeneca AB | Indole derivatives with vascular damaging activity |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| JP2005516936A (ja) | 2001-12-18 | 2005-06-09 | アストラゼネカ・アクチエボラーグ | Ｎ−ピラジニル−チエニルスルホンアミドおよびケモカイン媒介疾患の治療におけるそれらの使用 |
| TWI328007B (en) * | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
| SE0301650D0 (sv) * | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
| SE0301653D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0301654D0 (sv) * | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| SE0302304D0 (sv) * | 2003-08-27 | 2003-08-27 | Astrazeneca Ab | Novel compounds |
-
2006
- 2006-11-29 TW TW095144144A patent/TW200730512A/zh unknown
- 2006-12-11 EP EP06835834A patent/EP1968951B1/en active Active
- 2006-12-11 AU AU2006325573A patent/AU2006325573A1/en not_active Abandoned
- 2006-12-11 RU RU2008122401/04A patent/RU2008122401A/ru not_active Application Discontinuation
- 2006-12-11 BR BRPI0619602-0A patent/BRPI0619602A2/pt not_active Application Discontinuation
- 2006-12-11 ES ES06835834T patent/ES2366807T3/es active Active
- 2006-12-11 WO PCT/SE2006/001409 patent/WO2007069978A1/en not_active Ceased
- 2006-12-11 UY UY29999A patent/UY29999A1/es not_active Application Discontinuation
- 2006-12-11 KR KR1020087016880A patent/KR20080091139A/ko not_active Withdrawn
- 2006-12-11 CN CN2006800527066A patent/CN101370793B/zh not_active Expired - Fee Related
- 2006-12-11 JP JP2008545537A patent/JP2009519332A/ja active Pending
- 2006-12-11 CA CA002631342A patent/CA2631342A1/en not_active Abandoned
- 2006-12-11 AT AT06835834T patent/ATE513819T1/de not_active IP Right Cessation
- 2006-12-11 CL CL200603449A patent/CL2006003449A1/es unknown
- 2006-12-11 US US12/096,513 patent/US20080293742A1/en not_active Abandoned
- 2006-12-12 AR ARP060105466A patent/AR058319A1/es unknown
-
2008
- 2008-05-27 IL IL191761A patent/IL191761A0/en unknown
- 2008-06-05 ZA ZA200804921A patent/ZA200804921B/xx unknown
- 2008-07-04 EC EC2008008603A patent/ECSP088603A/es unknown
- 2008-07-08 NO NO20083070A patent/NO20083070L/no not_active Application Discontinuation
-
2009
- 2009-12-08 US US12/633,548 patent/US20100144759A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP088603A (es) | 2008-08-29 |
| US20100144759A1 (en) | 2010-06-10 |
| ATE513819T1 (de) | 2011-07-15 |
| ZA200804921B (en) | 2009-09-30 |
| UY29999A1 (es) | 2007-07-31 |
| NO20083070L (no) | 2008-08-28 |
| CN101370793B (zh) | 2012-01-04 |
| ES2366807T3 (es) | 2011-10-25 |
| WO2007069978A1 (en) | 2007-06-21 |
| US20080293742A1 (en) | 2008-11-27 |
| CN101370793A (zh) | 2009-02-18 |
| RU2008122401A (ru) | 2010-01-20 |
| EP1968951B1 (en) | 2011-06-22 |
| CL2006003449A1 (es) | 2008-02-08 |
| KR20080091139A (ko) | 2008-10-09 |
| IL191761A0 (en) | 2008-12-29 |
| EP1968951A1 (en) | 2008-09-17 |
| AR058319A1 (es) | 2008-01-30 |
| BRPI0619602A2 (pt) | 2011-10-11 |
| JP2009519332A (ja) | 2009-05-14 |
| AU2006325573A1 (en) | 2007-06-21 |
| HK1121760A1 (zh) | 2009-04-30 |
| CA2631342A1 (en) | 2007-06-21 |
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