TW200738728A - HIV integrase inhibitors - Google Patents
HIV integrase inhibitorsInfo
- Publication number
- TW200738728A TW200738728A TW095142505A TW95142505A TW200738728A TW 200738728 A TW200738728 A TW 200738728A TW 095142505 A TW095142505 A TW 095142505A TW 95142505 A TW95142505 A TW 95142505A TW 200738728 A TW200738728 A TW 200738728A
- Authority
- TW
- Taiwan
- Prior art keywords
- hiv integrase
- hiv
- integrase inhibitors
- treating
- encompasses
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- -1 bicyclic pyrimidinone compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73778105P | 2005-11-17 | 2005-11-17 | |
| US11/590,637 US8039458B2 (en) | 2005-11-17 | 2006-10-31 | HIV integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200738728A true TW200738728A (en) | 2007-10-16 |
Family
ID=38041727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095142505A TW200738728A (en) | 2005-11-17 | 2006-11-17 | HIV integrase inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8039458B2 (zh) |
| EP (1) | EP1948666B1 (zh) |
| JP (1) | JP2009515981A (zh) |
| KR (1) | KR20080069254A (zh) |
| CN (1) | CN101360752B (zh) |
| AR (1) | AR057896A1 (zh) |
| AT (1) | ATE461202T1 (zh) |
| AU (1) | AU2006316582B2 (zh) |
| CY (1) | CY1110665T1 (zh) |
| DE (1) | DE602006013025D1 (zh) |
| DK (1) | DK1948666T3 (zh) |
| ES (1) | ES2341132T3 (zh) |
| HR (1) | HRP20100247T1 (zh) |
| NO (1) | NO20081935L (zh) |
| PE (1) | PE20071080A1 (zh) |
| PL (1) | PL1948666T3 (zh) |
| PT (1) | PT1948666E (zh) |
| SI (1) | SI1948666T1 (zh) |
| TW (1) | TW200738728A (zh) |
| WO (1) | WO2007061714A1 (zh) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| WO2009097992A1 (en) | 2008-02-07 | 2009-08-13 | Bayer Cropscience Ag | Insecticidal arylpyrrolines |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| MX2011003637A (es) * | 2008-10-06 | 2011-04-27 | Merck Sharp & Dohme | Inhibidores de la integrasa del virus de inmunodeficiencia humana. |
| US8143244B2 (en) | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| JP2012527414A (ja) | 2009-05-19 | 2012-11-08 | バイエル・クロップサイエンス・アーゲー | 殺虫性アリールピロリン |
| EA019558B1 (ru) * | 2009-10-13 | 2014-04-30 | Эланко Энимал Хэлс Аиэлэнд Лимитед | Макроциклические ингибиторы интегразы |
| US8383639B2 (en) * | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ１１９モジュレーターとしてのｎ−シクロプロピル−ｎ−ピペリジニルベンズアミド |
| EP2718288B1 (en) | 2011-06-09 | 2015-03-11 | Boehringer Ingelheim International GmbH | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
| EP2785184B1 (en) | 2011-11-30 | 2020-06-10 | Emory University | Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv |
| WO2014019967A1 (en) | 2012-08-02 | 2014-02-06 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof |
| US9714243B2 (en) | 2012-12-17 | 2017-07-25 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as HIV integrase inhibitors |
| EP2986291B1 (en) | 2013-04-16 | 2020-05-27 | Merck Sharp & Dohme Corp. | 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors |
| EP2988742A4 (en) * | 2013-04-22 | 2016-10-19 | Abbvie Inc | THIAZOLES AND USES THEREOF |
| LT2997033T (lt) | 2013-05-17 | 2018-02-12 | Merck Sharp & Dohme Corp. | Kondensuoti tricikliniai heterocikliniai junginiai, kaip živ integrazės inhibitoriai |
| US9951079B2 (en) | 2013-06-13 | 2018-04-24 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as HIV integrase inhibitors |
| EP3049081B1 (en) | 2013-09-27 | 2019-11-27 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
| JP6660393B2 (ja) * | 2015-01-16 | 2020-03-11 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ４−シアノピペリジン塩酸塩を調製する方法 |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| WO2017087257A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
| EP3389380B1 (en) | 2015-12-15 | 2021-07-21 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| WO2018010163A1 (zh) * | 2016-07-15 | 2018-01-18 | 泸州东方农化有限公司 | 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体 |
| CN110062627A (zh) | 2016-12-02 | 2019-07-26 | 默沙东公司 | 可用作hiv整合酶抑制剂的三环杂环化合物 |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| EP3573984A4 (en) | 2017-01-26 | 2020-07-29 | Merck Sharp & Dohme Corp. | USEFUL SUBSTITUTE QUINOLIZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| CN113372335B (zh) * | 2021-07-05 | 2023-02-24 | 山东大学 | 一种含有1,2,4-三唑硫醚的苯丙氨酸衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050087865A (ko) * | 2002-12-27 | 2005-08-31 | 이스티투토 디 리세르쉐 디 비올로지아 몰레콜라레 피. 안젤레티에스.피.에이. | ＨＩＶ 인테그라제 억제제로서 유용한테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘 및 관련화합물 |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| CN101146811B (zh) * | 2005-03-31 | 2012-01-11 | P.安杰莱蒂分子生物学研究所 | Hiv整合酶抑制剂 |
| WO2006121831A2 (en) | 2005-05-10 | 2006-11-16 | Merck & Co., Inc. | Hiv integrase inhibitors |
-
2006
- 2006-10-31 US US11/590,637 patent/US8039458B2/en active Active
- 2006-11-15 PE PE2006001455A patent/PE20071080A1/es not_active Application Discontinuation
- 2006-11-15 SI SI200630642T patent/SI1948666T1/sl unknown
- 2006-11-15 WO PCT/US2006/044320 patent/WO2007061714A1/en not_active Ceased
- 2006-11-15 PT PT06837651T patent/PT1948666E/pt unknown
- 2006-11-15 KR KR1020087014533A patent/KR20080069254A/ko not_active Ceased
- 2006-11-15 DK DK06837651.6T patent/DK1948666T3/da active
- 2006-11-15 EP EP06837651A patent/EP1948666B1/en active Active
- 2006-11-15 ES ES06837651T patent/ES2341132T3/es active Active
- 2006-11-15 CN CN2006800512376A patent/CN101360752B/zh not_active Expired - Fee Related
- 2006-11-15 PL PL06837651T patent/PL1948666T3/pl unknown
- 2006-11-15 DE DE602006013025T patent/DE602006013025D1/de active Active
- 2006-11-15 AU AU2006316582A patent/AU2006316582B2/en not_active Ceased
- 2006-11-15 JP JP2008541302A patent/JP2009515981A/ja active Pending
- 2006-11-15 AT AT06837651T patent/ATE461202T1/de active
- 2006-11-15 HR HR20100247T patent/HRP20100247T1/hr unknown
- 2006-11-16 AR ARP060105027A patent/AR057896A1/es unknown
- 2006-11-17 TW TW095142505A patent/TW200738728A/zh unknown
-
2008
- 2008-04-23 NO NO20081935A patent/NO20081935L/no not_active Application Discontinuation
-
2010
- 2010-06-11 CY CY20101100533T patent/CY1110665T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101360752A (zh) | 2009-02-04 |
| AU2006316582A1 (en) | 2007-05-31 |
| EP1948666A1 (en) | 2008-07-30 |
| US20070111984A1 (en) | 2007-05-17 |
| HRP20100247T1 (hr) | 2010-06-30 |
| DK1948666T3 (da) | 2010-05-25 |
| PT1948666E (pt) | 2010-05-17 |
| KR20080069254A (ko) | 2008-07-25 |
| NO20081935L (no) | 2008-06-24 |
| PE20071080A1 (es) | 2007-11-19 |
| PL1948666T3 (pl) | 2010-08-31 |
| ATE461202T1 (de) | 2010-04-15 |
| JP2009515981A (ja) | 2009-04-16 |
| CY1110665T1 (el) | 2015-06-10 |
| ES2341132T3 (es) | 2010-06-15 |
| EP1948666B1 (en) | 2010-03-17 |
| DE602006013025D1 (de) | 2010-04-29 |
| SI1948666T1 (sl) | 2010-06-30 |
| US8039458B2 (en) | 2011-10-18 |
| CN101360752B (zh) | 2012-09-05 |
| WO2007061714A1 (en) | 2007-05-31 |
| AR057896A1 (es) | 2007-12-26 |
| AU2006316582B2 (en) | 2012-01-19 |
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