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TW200736268A - Synthesis of alendronate sodium trihydrate - Google Patents

Synthesis of alendronate sodium trihydrate

Info

Publication number
TW200736268A
TW200736268A TW095140904A TW95140904A TW200736268A TW 200736268 A TW200736268 A TW 200736268A TW 095140904 A TW095140904 A TW 095140904A TW 95140904 A TW95140904 A TW 95140904A TW 200736268 A TW200736268 A TW 200736268A
Authority
TW
Taiwan
Prior art keywords
synthesis
alendronate sodium
sodium trihydrate
water
trihydrate
Prior art date
Application number
TW095140904A
Other languages
Chinese (zh)
Inventor
Tomas O'ceallaigh
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TW200736268A publication Critical patent/TW200736268A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention describes a process for the synthesis of alendronate sodium trihydrate from the reaction of alendronic acid, either anhydrous or in a hydrated state, in an aqueous slurry with sodium hydroxide in water. The pH is adjusted into the range 4.3 - 4.4, the solution is concentrated and the sodium salt thus formed is isolated by crystallization from water.
TW095140904A 2005-11-07 2006-11-03 Synthesis of alendronate sodium trihydrate TW200736268A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73417905P 2005-11-07 2005-11-07

Publications (1)

Publication Number Publication Date
TW200736268A true TW200736268A (en) 2007-10-01

Family

ID=37944596

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095140904A TW200736268A (en) 2005-11-07 2006-11-03 Synthesis of alendronate sodium trihydrate

Country Status (3)

Country Link
AR (1) AR058168A1 (en)
TW (1) TW200736268A (en)
WO (1) WO2007056417A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
HUP0203078A3 (en) * 1998-08-27 2005-01-28 Teva Pharma Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
WO2007056417A3 (en) 2007-07-05
AR058168A1 (en) 2008-01-23
WO2007056417A2 (en) 2007-05-18

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