TW200716572A - Peroxisome proliferator activated receptor alpha agonists - Google Patents

Peroxisome proliferator activated receptor alpha agonists

Info

Publication number: TW200716572A
Authority: TW; Taiwan
Prior art keywords: activated receptor; receptor alpha; peroxisome proliferator; proliferator activated; alpha agonists
Prior art date: 2000-11-10

Application number

TW095138799A

Other languages

English (en)

Inventor

Ivan Collado Cano

Samuel James Dominianni

Garret Jay Etgen Junior

Cristina Garcia-Paredes

Richard Duane Johnston

Edward Letourneau Michael

Bryan Mantlo Nathan

John Martinelli Michael

Ray Mayhugh Daniel

Saeed Ashraf

Craig Thompson Ricahrd

Wang Xiadong

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-10

Filing date

2001-11-08

Publication date

2007-05-01

2001-11-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2007-05-01 Publication of TW200716572A publication Critical patent/TW200716572A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/22—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups further bound to nitrogen atoms, e.g. hydrazidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
- C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Cultivation Of Plants (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

TW095138799A 2000-11-10 2001-11-08 Peroxisome proliferator activated receptor alpha agonists TW200716572A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24731700P	2000-11-10	2000-11-10

Publications (1)

Publication Number	Publication Date
TW200716572A true TW200716572A (en)	2007-05-01

Family

ID=22934453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095138799A TW200716572A (en)	2000-11-10	2001-11-08	Peroxisome proliferator activated receptor alpha agonists

Country Status (34)

Country	Link
US (3)	US7304062B2 (zh)
EP (1)	EP1335908B1 (zh)
JP (1)	JP4243101B2 (zh)
KR (1)	KR100839705B1 (zh)
CN (1)	CN1479728A (zh)
AR (1)	AR031305A1 (zh)
AT (1)	ATE386026T1 (zh)
AU (3)	AU2002228592B8 (zh)
BR (1)	BR0114986A (zh)
CA (1)	CA2421154A1 (zh)
CY (1)	CY1107388T1 (zh)
CZ (1)	CZ20031283A3 (zh)
DE (1)	DE60132799T2 (zh)
DK (1)	DK1335908T3 (zh)
EA (1)	EA006920B1 (zh)
EC (1)	ECSP034595A (zh)
ES (1)	ES2300378T3 (zh)
HR (1)	HRP20030365A2 (zh)
HU (1)	HUP0301655A2 (zh)
IL (2)	IL154840A0 (zh)
MX (1)	MXPA03004141A (zh)
MY (1)	MY157884A (zh)
NO (1)	NO20032059L (zh)
NZ (1)	NZ524569A (zh)
PE (1)	PE20020693A1 (zh)
PL (1)	PL362692A1 (zh)
PT (1)	PT1335908E (zh)
SI (1)	SI1335908T1 (zh)
SK (1)	SK5412003A3 (zh)
SV (1)	SV2003000727A (zh)
TW (1)	TW200716572A (zh)
UA (1)	UA82048C2 (zh)
WO (1)	WO2002038553A2 (zh)
ZA (1)	ZA200302517B (zh)

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WO2003043997A1 (en) *	2001-11-15	2003-05-30	Eli Lilly And Company	Peroxisome proliferator activated receptor alpha agonists
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EP1517882A1 (en)	2002-06-19	2005-03-30	Eli Lilly And Company	Amide linker peroxisome proliferator activated receptor modulators
TW200505441A (en)	2003-03-24	2005-02-16	Hoffmann La Roche	Non-nucleoside reverse transcriptase inhibitorsⅠ
FR2866339B1 (fr) *	2004-02-18	2006-05-05	Pf Medicament	Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
CN1993332B (zh) *	2004-07-27	2011-04-06	弗·哈夫曼-拉罗切有限公司	作为非核苷逆转录酶抑制剂的苄基三唑酮化合物
KR100803481B1 (ko) *	2004-07-27	2008-02-14	에프. 호프만-라 로슈 아게	비-뉴클레오사이드 역전사효소 억제제로서의벤질트라이아졸론 화합물
US8293778B2 (en)	2004-07-27	2012-10-23	Roche Palo Alto Llc	Heterocyclic antiviral compounds
CN101014595A (zh) *	2004-08-11	2007-08-08	杏林制药株式会社	新型环状氨基苯甲酸衍生物
WO2006068199A1 (ja) *	2004-12-22	2006-06-29	Mochida Pharmaceutical Co., Ltd.	代謝的に安定な３－オキシ－１，２，４－トリアゾール誘導体
DOP2006000018A (es) *	2005-01-28	2006-07-15	Lilly Co Eli	Formulaciones y regimen de dosificación para moduladores alfa de ppar
FR2882750B1 (fr)	2005-03-03	2007-05-11	Pierre Fabre Medicament Sa	Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
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WO2007126043A1 (ja) *	2006-04-27	2007-11-08	Mitsubishi Tanabe Pharma Corporation	チアゾール環を含むカルボン酸誘導体の医薬用途
EP2129667A2 (en) *	2007-02-23	2009-12-09	Eli Lilly And Company	Peroxisome proliferator activated receptor modulators
WO2008119662A1 (en)	2007-03-29	2008-10-09	F. Hoffmann-La Roche Ag	Non-nucleoside reverse transcriptase inhibitors
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CN101643451B (zh) *	2008-08-07	2013-03-06	浙江海正药业股份有限公司	过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法
KR101290868B1 (ko)	2008-12-01	2013-07-29	미쓰비시 타나베 파마 코퍼레이션	티아졸환을 포함하는 카르복실산 유도체 및 그의 의약 용도
US20110167512A1 (en) *	2009-03-02	2011-07-07	Nunhems B.V.	Hybrid artichoke variety nun 4006 ar
US8575430B2 (en) *	2010-03-02	2013-11-05	Nunhems, B.V.	Hybrid artichoke variety NUN 4006 AR
DE102010001064A1 (de) *	2009-03-18	2010-09-23	Bayer Schering Pharma Aktiengesellschaft	Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
US20100245582A1 (en) *	2009-03-25	2010-09-30	Syclipse Technologies, Inc.	System and method of remote surveillance and applications therefor
US20130156720A1 (en)	2010-08-27	2013-06-20	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US8648233B2 (en) *	2010-09-20	2014-02-11	Nunhems B.V.	Hybrid artichoke variety NUN 4021 AR
US8669420B2 (en)	2012-02-29	2014-03-11	Nunhems B.V.	Hybrid artichoke variety NUN 4060 AR
WO2013134562A1 (en)	2012-03-09	2013-09-12	Inception 2, Inc.	Triazolone compounds and uses thereof
MX376108B (es) *	2012-12-20	2025-03-07	Tempest Therapeutics Inc	Compuestos de triazolona y usos de los mismos.
KR20160048988A (ko) *	2013-09-06	2016-05-04	인셉션 2 인코퍼레이티드	트라이아졸론 화합물 및 이의 용도
RU177130U1 (ru) *	2017-11-29	2018-02-09	Владимир Алексеевич Коннов	Плита изоляционная облицовочная
JPWO2021205803A1 (zh)	2020-04-10	2021-10-14
CN112774869B (zh) *	2020-12-25	2022-09-16	厦门紫金矿冶技术有限公司	黄铁矿抑制剂及其制备和在铜铅锌多金属硫化矿中的应用
CN114853686B (zh) *	2021-08-23	2023-06-20	中国药科大学	三氮唑酮类化合物及其医药用途
CN115894379B (zh) *	2022-01-20	2025-06-27	哈尔滨三联药业股份有限公司	海因类化合物及其医药用途
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2001
- 2001-09-11 UA UA2003054187A patent/UA82048C2/uk unknown
- 2001-11-07 AR ARP010105214A patent/AR031305A1/es unknown
- 2001-11-08 MY MYPI20015155A patent/MY157884A/en unknown
- 2001-11-08 TW TW095138799A patent/TW200716572A/zh unknown
- 2001-11-08 PE PE2001001108A patent/PE20020693A1/es not_active Application Discontinuation
- 2001-11-09 US US10/415,673 patent/US7304062B2/en not_active Expired - Fee Related
- 2001-11-09 SK SK541-2003A patent/SK5412003A3/sk not_active Application Discontinuation
- 2001-11-09 PL PL01362692A patent/PL362692A1/xx unknown
- 2001-11-09 BR BR0114986-5A patent/BR0114986A/pt not_active IP Right Cessation
- 2001-11-09 CA CA002421154A patent/CA2421154A1/en not_active Abandoned
- 2001-11-09 AU AU2002228592A patent/AU2002228592B8/en not_active Ceased
- 2001-11-09 JP JP2002541088A patent/JP4243101B2/ja not_active Expired - Fee Related
- 2001-11-09 HU HU0301655A patent/HUP0301655A2/hu unknown
- 2001-11-09 IL IL15484001A patent/IL154840A0/xx unknown
- 2001-11-09 CN CNA018185878A patent/CN1479728A/zh active Pending
- 2001-11-09 EP EP01989704A patent/EP1335908B1/en not_active Expired - Lifetime
- 2001-11-09 EA EA200300558A patent/EA006920B1/ru not_active IP Right Cessation
- 2001-11-09 KR KR1020037006301A patent/KR100839705B1/ko not_active Expired - Fee Related
- 2001-11-09 PT PT01989704T patent/PT1335908E/pt unknown
- 2001-11-09 MX MXPA03004141A patent/MXPA03004141A/es active IP Right Grant
- 2001-11-09 CZ CZ20031283A patent/CZ20031283A3/cs unknown
- 2001-11-09 AT AT01989704T patent/ATE386026T1/de not_active IP Right Cessation
- 2001-11-09 DK DK01989704T patent/DK1335908T3/da active
- 2001-11-09 AU AU2859202A patent/AU2859202A/xx active Pending
- 2001-11-09 ES ES01989704T patent/ES2300378T3/es not_active Expired - Lifetime
- 2001-11-09 SV SV2001000727A patent/SV2003000727A/es not_active Application Discontinuation
- 2001-11-09 HR HR20030365A patent/HRP20030365A2/hr not_active Application Discontinuation
- 2001-11-09 WO PCT/US2001/042928 patent/WO2002038553A2/en not_active Ceased
- 2001-11-09 SI SI200130828T patent/SI1335908T1/sl unknown
- 2001-11-09 NZ NZ524569A patent/NZ524569A/en unknown
- 2001-11-09 DE DE60132799T patent/DE60132799T2/de not_active Expired - Fee Related
2003
- 2003-03-10 IL IL154840A patent/IL154840A/en active IP Right Grant
- 2003-03-31 ZA ZA200302517A patent/ZA200302517B/en unknown
- 2003-05-08 NO NO20032059A patent/NO20032059L/no unknown
- 2003-05-08 EC EC2003004595A patent/ECSP034595A/es unknown
2006
- 2006-06-29 AU AU2006202811A patent/AU2006202811A1/en not_active Abandoned
2007
- 2007-07-26 US US11/828,446 patent/US20090062358A1/en not_active Abandoned
2008
- 2008-04-10 CY CY20081100391T patent/CY1107388T1/el unknown
- 2008-06-27 US US12/215,466 patent/US7868225B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR20030048133A (ko)	2003-06-18
CA2421154A1 (en)	2002-05-16
BR0114986A (pt)	2003-09-23
HK1058790A1 (zh)	2004-06-04
DE60132799T2 (de)	2009-03-19
EA200300558A1 (ru)	2004-02-26
NO20032059L (no)	2003-06-24
UA82048C2 (uk)	2008-03-11
HRP20030365A2 (en)	2003-08-31
US20090044299A1 (en)	2009-02-12
EP1335908B1 (en)	2008-02-13
WO2002038553A2 (en)	2002-05-16
US20090062358A1 (en)	2009-03-05
JP2004513166A (ja)	2004-04-30
ES2300378T3 (es)	2008-06-16
SV2003000727A (es)	2003-01-13
ZA200302517B (en)	2004-06-30
HUP0301655A2 (hu)	2003-12-29
DE60132799D1 (de)	2008-03-27
US7304062B2 (en)	2007-12-04
ATE386026T1 (de)	2008-03-15
MY157884A (en)	2016-08-01
SK5412003A3 (en)	2004-01-08
AU2002228592B8 (en)	2006-08-24
EP1335908A2 (en)	2003-08-20
NO20032059D0 (no)	2003-05-08
WO2002038553A3 (en)	2003-05-01
DK1335908T3 (da)	2008-06-02
IL154840A (en)	2009-09-22
AU2859202A (en)	2002-05-21
US20040102500A1 (en)	2004-05-27
PE20020693A1 (es)	2002-08-05
AU2006202811A1 (en)	2006-07-20
EA006920B1 (ru)	2006-04-28
IL154840A0 (en)	2003-10-31
CN1479728A (zh)	2004-03-03
KR100839705B1 (ko)	2008-06-19
CZ20031283A3 (cs)	2003-09-17
JP4243101B2 (ja)	2009-03-25
US7868225B2 (en)	2011-01-11
ECSP034595A (es)	2003-06-25
PL362692A1 (en)	2004-11-02
AR031305A1 (es)	2003-09-17
PT1335908E (pt)	2008-05-08
NZ524569A (en)	2006-05-26
SI1335908T1 (sl)	2008-08-31
AU2002228592B2 (en)	2006-04-27
MXPA03004141A (es)	2003-08-19
CY1107388T1 (el)	2012-12-19

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