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TW200700416A - 'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites - Google Patents

'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites

Info

Publication number
TW200700416A
TW200700416A TW095108781A TW95108781A TW200700416A TW 200700416 A TW200700416 A TW 200700416A TW 095108781 A TW095108781 A TW 095108781A TW 95108781 A TW95108781 A TW 95108781A TW 200700416 A TW200700416 A TW 200700416A
Authority
TW
Taiwan
Prior art keywords
metabolites
piperazinyl
pyrimidinyl
methylphenyl
hydroxyethyl
Prior art date
Application number
TW095108781A
Other languages
English (en)
Inventor
Vinod Kumar Arora
Lisa Joy Christopher
dong-hui Cui
wen-ying Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of TW200700416A publication Critical patent/TW200700416A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW095108781A 2005-03-15 2006-03-15 'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites TW200700416A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66177705P 2005-03-15 2005-03-15
US72873205P 2005-10-20 2005-10-20

Publications (1)

Publication Number Publication Date
TW200700416A true TW200700416A (en) 2007-01-01

Family

ID=36603642

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095108781A TW200700416A (en) 2005-03-15 2006-03-15 'n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites

Country Status (6)

Country Link
US (1) US7622473B2 (zh)
EP (1) EP1863807A1 (zh)
AR (1) AR053169A1 (zh)
PE (1) PE20061394A1 (zh)
TW (1) TW200700416A (zh)
WO (1) WO2006099474A1 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120033357A (ko) * 2007-10-23 2012-04-06 테바 파마슈티컬 인더스트리즈 리미티드 다사티닙 다형체 및 이의 제조 방법
WO2009076373A1 (en) * 2007-12-10 2009-06-18 Concert Pharmaceuticals Inc. Heterocyclic kinase inhibitors
BRPI0800951A2 (pt) * 2008-04-09 2012-02-22 Ems Sa novos compostos derivados de taurina e seus usos, processo de sua preparação e composições farmacêuticas contendo os mesmos
CN102105583A (zh) * 2008-07-23 2011-06-22 奥林巴斯株式会社 从粪便试样中回收核酸的方法、核酸分析方法以及粪便试样处理装置
CN101967142B (zh) * 2010-05-17 2012-05-30 苏州波锐生物医药科技有限公司 噻唑酰胺类化合物及其在治疗恶性肿瘤中的药物用途
WO2012129381A1 (en) 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
CN103172627B (zh) * 2011-12-26 2015-11-18 南京优科生物医药有限公司 杂环嘧啶苯或吡啶苯类化合物及其应用
GB2508652A (en) * 2012-12-07 2014-06-11 Agency Science Tech & Res Heterocyclic piperazine derivatives
CN103012395B (zh) * 2013-01-04 2015-05-13 南京优科生物医药有限公司 一种杂环嘧啶苯类化合物的制备方法
CN104151321B (zh) * 2013-05-15 2016-09-07 复旦大学 N-(2-氯-6-甲基苯基)-2[(2-甲基嘧啶-4-基)氨基]噻唑-5-甲酰胺化合物及其制备方法和用途
CN103319476B (zh) * 2013-06-13 2015-12-02 济南德爱医药技术有限公司 一种激酶抑制剂
CN105503852B (zh) * 2014-09-26 2018-06-22 山东新时代药业有限公司 噻唑甲酰胺氮氧化物
CN106279143A (zh) * 2015-05-11 2017-01-04 天津国际生物医药联合研究院 噻唑杂环类化合物及其制备方法和应用
US10479786B2 (en) 2016-12-13 2019-11-19 Princeton Drug Discovery, Inc Protein kinase inhibitors
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF
CN112402422A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 氟取代的2-氨基噻唑-5-芳香族甲酰胺的用途
CN112409349A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 激酶抑制剂及其制备、药物组合物和用途
CN119841819A (zh) * 2023-10-16 2025-04-18 北京大学 靶向bcr-abl的降解剂及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
EP2308833A3 (en) 1999-04-15 2011-09-28 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US20050009891A1 (en) 2003-07-09 2005-01-13 Lee Francis Y. Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US20060069101A1 (en) * 2004-09-27 2006-03-30 Kim Kyoung S Prodrugs of protein tyrosine kinase inhibitors
CA2593803A1 (en) * 2005-01-26 2006-08-03 Irm Llc Thiazole-amide compounds and compsitions as protein kinase inhibitors

Also Published As

Publication number Publication date
US7622473B2 (en) 2009-11-24
PE20061394A1 (es) 2006-12-15
US20060211705A1 (en) 2006-09-21
EP1863807A1 (en) 2007-12-12
AR053169A1 (es) 2007-04-25
WO2006099474A1 (en) 2006-09-21

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