TW200700408A - New cgrp-antagonists, process for preparing them and their use as pharmaceutical compositions - Google Patents
New cgrp-antagonists, process for preparing them and their use as pharmaceutical compositionsInfo
- Publication number
- TW200700408A TW200700408A TW095109753A TW95109753A TW200700408A TW 200700408 A TW200700408 A TW 200700408A TW 095109753 A TW095109753 A TW 095109753A TW 95109753 A TW95109753 A TW 95109753A TW 200700408 A TW200700408 A TW 200700408A
- Authority
- TW
- Taiwan
- Prior art keywords
- antagonists
- pharmaceutical compositions
- preparing
- cgrp
- salts
- Prior art date
Links
- 229940127597 CGRP antagonist Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- 229910052805 deuterium Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to the CGRP-antagonists of general formula I, wherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP050101139A AR049625A1 (en) | 2004-03-29 | 2005-03-23 | CGRP ANTAGONISTS, PROCEDURE FOR PREPARATION AS WELL AS ITS USE AS A MEDICINAL PRODUCT |
| PE20050000 | 2005-03-23 | ||
| PCT/EP2005/003094 WO2005092880A1 (en) | 2004-03-29 | 2005-03-23 | Selected cgrp antagonists, methods for the production thereof and their use as medicaments |
| PCT/EP2005/004104 WO2005103037A2 (en) | 2004-04-22 | 2005-04-18 | Selected cgrp antagonists, methods for the production thereof, and use thereof as medicaments |
| EP05021283A EP1770091A1 (en) | 2005-09-29 | 2005-09-29 | CGRP-antagonists, process for their preparation as well as their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200700408A true TW200700408A (en) | 2007-01-01 |
Family
ID=57910306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095109753A TW200700408A (en) | 2005-03-23 | 2006-03-22 | New cgrp-antagonists, process for preparing them and their use as pharmaceutical compositions |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW200700408A (en) |
-
2006
- 2006-03-22 TW TW095109753A patent/TW200700408A/en unknown
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