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TW200626149A - Tricycles, their manufacture and use as pharmaceutical agents - Google Patents

Tricycles, their manufacture and use as pharmaceutical agents

Info

Publication number
TW200626149A
TW200626149A TW094132584A TW94132584A TW200626149A TW 200626149 A TW200626149 A TW 200626149A TW 094132584 A TW094132584 A TW 094132584A TW 94132584 A TW94132584 A TW 94132584A TW 200626149 A TW200626149 A TW 200626149A
Authority
TW
Taiwan
Prior art keywords
manufacture
tricycles
pharmaceutical agents
compounds
mentioned compounds
Prior art date
Application number
TW094132584A
Other languages
Chinese (zh)
Inventor
Guy Georges
Bernhard Goller
Hans-Willi Krell
Klaus-Peter Kuenkele
Anja Limberg
Petra Rueger
Matthias Rueth
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TW200626149A publication Critical patent/TW200626149A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
TW094132584A 2004-09-24 2005-09-21 Tricycles, their manufacture and use as pharmaceutical agents TW200626149A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04022753 2004-09-24
EP05010528 2005-05-13

Publications (1)

Publication Number Publication Date
TW200626149A true TW200626149A (en) 2006-08-01

Family

ID=35429559

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094132584A TW200626149A (en) 2004-09-24 2005-09-21 Tricycles, their manufacture and use as pharmaceutical agents

Country Status (10)

Country Link
EP (1) EP1793822A1 (en)
JP (1) JP2008514565A (en)
KR (1) KR100845749B1 (en)
AR (1) AR050949A1 (en)
AU (1) AU2005287459A1 (en)
CA (1) CA2580203A1 (en)
MX (1) MX2007003463A (en)
RU (1) RU2007115159A (en)
TW (1) TW200626149A (en)
WO (1) WO2006032519A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462639B2 (en) 2005-04-14 2008-12-09 Hoffmann-La Roche Inc. Aminopyrazole derivatives
AU2006326247A1 (en) * 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents
AU2007228940A1 (en) * 2006-03-23 2007-09-27 F. Hoffmann-La Roche Ag Substituted indazole derivatives, their manufacture and use as pharmaceutical agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501497A1 (en) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim NEW PYRROLO-BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
DE3740985A1 (en) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh USE OF LINEAR FURNISHED TRICYCLES AS AN INHIBITORS OF THE ERYTHROCYTE AGGREGATION

Also Published As

Publication number Publication date
MX2007003463A (en) 2007-05-23
EP1793822A1 (en) 2007-06-13
RU2007115159A (en) 2008-11-10
AU2005287459A1 (en) 2006-03-30
WO2006032519A1 (en) 2006-03-30
KR20070045339A (en) 2007-05-02
CA2580203A1 (en) 2006-03-30
JP2008514565A (en) 2008-05-08
AR050949A1 (en) 2006-12-06
KR100845749B1 (en) 2008-07-11

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