TW200604344A - Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof - Google Patents
Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereofInfo
- Publication number
- TW200604344A TW200604344A TW094118590A TW94118590A TW200604344A TW 200604344 A TW200604344 A TW 200604344A TW 094118590 A TW094118590 A TW 094118590A TW 94118590 A TW94118590 A TW 94118590A TW 200604344 A TW200604344 A TW 200604344A
- Authority
- TW
- Taiwan
- Prior art keywords
- mutants
- enzymes
- deoxy
- ribose
- relates
- Prior art date
Links
- 101000928995 Caenorhabditis elegans Putative deoxyribose-phosphate aldolase Proteins 0.000 title abstract 3
- 102100037802 Deoxyribose-phosphate aldolase Human genes 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 6
- 108090000790 Enzymes Proteins 0.000 abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 238000012216 screening Methods 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108700016241 Deoxyribose-phosphate aldolases Proteins 0.000 abstract 1
- 241001646716 Escherichia coli K-12 Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 102000030794 deoxyribose-phosphate aldolase Human genes 0.000 abstract 1
- 239000004174 erythrosine Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04076639 | 2004-06-04 | ||
| US57865504P | 2004-06-10 | 2004-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200604344A true TW200604344A (en) | 2006-02-01 |
Family
ID=34928263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094118590A TW200604344A (en) | 2004-06-04 | 2005-06-06 | Improved 2-deoxy-d-ribose 5-phosphate aldolases for, and use in production of 2,4,6-trideoxyhexoses and 6-halo- or 6-cyano-substituted derivatives thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090209001A1 (zh) |
| EP (1) | EP1751287A2 (zh) |
| JP (1) | JP2008541693A (zh) |
| CN (1) | CN1965084A (zh) |
| CA (1) | CA2568728A1 (zh) |
| MX (1) | MXPA06014090A (zh) |
| TW (1) | TW200604344A (zh) |
| WO (1) | WO2005118794A2 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2134696B1 (en) | 2007-04-03 | 2017-05-17 | LEK Pharmaceuticals d.d. | Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof |
| EP2185713B1 (en) | 2007-08-03 | 2014-09-10 | Pfizer Products Inc. | Process for preparing chiral compounds |
| US8404870B2 (en) | 2008-01-23 | 2013-03-26 | Lek Pharmaceuticals D.D. | ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylate and process for the production thereof |
| EP2459720B1 (en) * | 2009-07-30 | 2016-04-27 | Metabolic Explorer | Mutant glycerol dehydrogenase (glydh) for the production of a biochemical by fermentation |
| CA2822331A1 (en) | 2010-12-20 | 2012-07-19 | Lek Pharmaceuticals D.D. | Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof |
| EP2465936A1 (en) | 2010-12-20 | 2012-06-20 | LEK Pharmaceuticals d.d. | Enzymatic synthesis of statins and intermediates thereof |
| CN103409402B (zh) * | 2013-08-28 | 2015-05-27 | 南京博优康远生物医药科技有限公司 | 醛缩酶突变体 |
| CN104017795B (zh) * | 2014-05-27 | 2016-05-25 | 中国科学院天津工业生物技术研究所 | 一种利用醛缩酶生物合成2-脱氧稀少醛糖的方法 |
| CN105063000B (zh) * | 2015-08-28 | 2018-07-13 | 安徽丰原发酵技术工程研究有限公司 | 大肠杆菌2-脱氧-d-核糖-5-磷酸醛缩酶突变体及其制备方法 |
| GB201605354D0 (en) | 2016-03-30 | 2016-05-11 | Zuvasyntha Ltd | Modified enzyme |
| EP3478848A4 (en) | 2016-06-30 | 2020-01-29 | Ardra Inc. | METHOD AND MICRO-ORGANISMS FOR THE PRODUCTION OF FLAVORS AND PERFUME CHEMICALS |
| AU2019300836B2 (en) | 2018-07-09 | 2025-09-04 | Codexis, Inc. | Engineered deoxyribose-phosphate aldolases |
| CN111876404B (zh) * | 2020-07-30 | 2021-12-21 | 浙大宁波理工学院 | 一种醛缩酶突变体及其编码基因和应用 |
| CN113444712B (zh) * | 2021-05-26 | 2022-06-21 | 浙江工业大学 | 一种L-天冬氨酸-α-脱羧酶突变体及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005520510A (ja) * | 2002-03-14 | 2005-07-14 | ザ スクリプス リサーチ インスティチュート | 生体活性化合物を製造するためのシントンの合成 |
| JP2006512086A (ja) * | 2002-09-20 | 2006-04-13 | ダイヴァーサ コーポレイション | スタチンおよびスタチン中間体の合成のための酵素化学的方法 |
-
2005
- 2005-06-02 JP JP2007513867A patent/JP2008541693A/ja active Pending
- 2005-06-02 EP EP05746961A patent/EP1751287A2/en not_active Withdrawn
- 2005-06-02 WO PCT/EP2005/005989 patent/WO2005118794A2/en not_active Ceased
- 2005-06-02 CA CA002568728A patent/CA2568728A1/en not_active Abandoned
- 2005-06-02 US US11/628,232 patent/US20090209001A1/en not_active Abandoned
- 2005-06-02 CN CNA2005800180624A patent/CN1965084A/zh active Pending
- 2005-06-02 MX MXPA06014090A patent/MXPA06014090A/es not_active Application Discontinuation
- 2005-06-06 TW TW094118590A patent/TW200604344A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2568728A1 (en) | 2005-12-15 |
| CN1965084A (zh) | 2007-05-16 |
| WO2005118794A2 (en) | 2005-12-15 |
| US20090209001A1 (en) | 2009-08-20 |
| WO2005118794A3 (en) | 2006-02-16 |
| MXPA06014090A (es) | 2007-03-07 |
| JP2008541693A (ja) | 2008-11-27 |
| EP1751287A2 (en) | 2007-02-14 |
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