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TW200514571A - Pharmaceutical composition with improved solubility and fluidity - Google Patents

Pharmaceutical composition with improved solubility and fluidity

Info

Publication number
TW200514571A
TW200514571A TW093126705A TW93126705A TW200514571A TW 200514571 A TW200514571 A TW 200514571A TW 093126705 A TW093126705 A TW 093126705A TW 93126705 A TW93126705 A TW 93126705A TW 200514571 A TW200514571 A TW 200514571A
Authority
TW
Taiwan
Prior art keywords
pharmaceutical composition
water
fluidity
improved solubility
soluble
Prior art date
Application number
TW093126705A
Other languages
Chinese (zh)
Other versions
TWI344376B (en
Inventor
Hideyoshi Kanbe
Toshiaki Kurazumi
Teiji Murata
Original Assignee
Ssp Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ssp Co Ltd filed Critical Ssp Co Ltd
Publication of TW200514571A publication Critical patent/TW200514571A/en
Application granted granted Critical
Publication of TWI344376B publication Critical patent/TWI344376B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a pharmaceutical composition which is applicable with various hardly water-soluble drugs and can be produced by a simple method. In this pharmaceutical composition, the solubility and fluidity of a hardly water-soluble drug are improved. Specifically, disclosed is a pharmaceutical composition which contains granules obtained by granulating a mixture of a hardly water-soluble drug and a plasticizer using a water solution or a water-containing alcohol solution of a water-soluble polymer.
TW093126705A 2003-09-05 2004-09-03 Pharmaceutical composition having improved solubility and fluidity TWI344376B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003313853A JP4575654B2 (en) 2003-09-05 2003-09-05 Pharmaceutical composition with improved solubility and fluidity

Publications (2)

Publication Number Publication Date
TW200514571A true TW200514571A (en) 2005-05-01
TWI344376B TWI344376B (en) 2011-07-01

Family

ID=34269778

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093126705A TWI344376B (en) 2003-09-05 2004-09-03 Pharmaceutical composition having improved solubility and fluidity

Country Status (5)

Country Link
JP (1) JP4575654B2 (en)
KR (1) KR20060119860A (en)
CN (1) CN100389750C (en)
TW (1) TWI344376B (en)
WO (1) WO2005023222A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101247832B (en) * 2005-06-27 2011-12-28 第一三共株式会社 Pharmaceutical preparation containing an angiotensin II receptor antagonist and a calcium channel blocker
PL2089511T3 (en) * 2006-11-13 2015-02-27 Depuy Synthes Products Llc In vitro expansion of postpartum-derived cells using microcarriers
JP5201819B2 (en) * 2006-11-22 2013-06-05 エスエス製薬株式会社 Solid composition
WO2011108644A1 (en) * 2010-03-03 2011-09-09 ライオン株式会社 Solid pharmaceutical composition and pharmaceutical preparation
CN105343006B (en) * 2015-12-02 2019-05-14 北京大学 A kind of nanometer shell system and its preparation method and application carrying insoluble drug
CN105832680B (en) * 2016-05-12 2018-12-25 沈阳药科大学 A kind of pharmaceutical composition improving spirolactone In Vitro Dissolution and mobility
JP6918392B2 (en) * 2021-01-13 2021-08-11 築野食品工業株式会社 Yield improvement in powder production or generation, scattering or solidification inhibitor of fine powder in powder use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84875A1 (en) * 1983-06-27 1985-03-29 Oreal TINCTORIAL COMPOSITIONS FOR KERATINIC FIBERS BASED ON DIRECT DYES AND XANTHANE GUM
DE3720757A1 (en) * 1987-06-24 1989-01-05 Bayer Ag DHP COAT TABLET
CH675537A5 (en) * 1988-03-25 1990-10-15 Ciba Geigy Ag
JP3037393B2 (en) * 1990-10-22 2000-04-24 大正薬品工業株式会社 Method for producing solid drug for oral administration
EP0559897B1 (en) * 1990-11-30 1998-03-04 Yamanouchi Pharmaceutical Co. Ltd. Quick release coated preparation
US5651983A (en) * 1993-02-26 1997-07-29 The Procter & Gamble Company Bisacodyl dosage form for colonic delivery
US5656290A (en) * 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
JP3247511B2 (en) * 1993-09-07 2002-01-15 山之内製薬株式会社 Pharmaceutical composition
JP3096666B2 (en) * 1996-11-01 2000-10-10 藤崎電機株式会社 Method and apparatus for granulating powder
JP3870470B2 (en) * 1997-02-07 2007-01-17 大正製薬株式会社 Multiple unit type sustained release tablets
DE19709663A1 (en) * 1997-03-10 1998-09-17 Basf Ag Use of redispersible polymer powders or polymer granules as binders for the production of solid pharmaceutical dosage forms
JP4063386B2 (en) * 1998-01-29 2008-03-19 キッセイ薬品工業株式会社 Rapid-release oral pharmaceutical composition
JP4438121B2 (en) * 1998-04-27 2010-03-24 大正製薬株式会社 Intraoral rapidly disintegrating tablet and method for producing the same
GB9816899D0 (en) * 1998-08-05 1998-09-30 Boots Co Plc Therapeutic agents
EP1203580A4 (en) * 1999-06-18 2004-06-30 Takeda Chemical Industries Ltd SOLID PREPARATIONS WITH FAST DISINTEGRATION

Also Published As

Publication number Publication date
CN100389750C (en) 2008-05-28
JP4575654B2 (en) 2010-11-04
HK1092711A1 (en) 2007-02-16
WO2005023222A1 (en) 2005-03-17
JP2005082503A (en) 2005-03-31
CN1842324A (en) 2006-10-04
TWI344376B (en) 2011-07-01
KR20060119860A (en) 2006-11-24

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees