TW200502248A - Process for decreasing aggregate levels of pegylated protein - Google Patents
Process for decreasing aggregate levels of pegylated proteinInfo
- Publication number
- TW200502248A TW200502248A TW092126051A TW92126051A TW200502248A TW 200502248 A TW200502248 A TW 200502248A TW 092126051 A TW092126051 A TW 092126051A TW 92126051 A TW92126051 A TW 92126051A TW 200502248 A TW200502248 A TW 200502248A
- Authority
- TW
- Taiwan
- Prior art keywords
- pegylated protein
- aggregate levels
- decreasing aggregate
- decreasing
- desired pegylated
- Prior art date
Links
- 108091006006 PEGylated Proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003247 decreasing effect Effects 0.000 title 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000011176 pooling Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. These method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222702P | 2002-09-20 | 2002-09-20 | |
| US10/646,798 US20040048315A1 (en) | 2002-08-28 | 2003-08-25 | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200502248A true TW200502248A (en) | 2005-01-16 |
| TWI318629B TWI318629B (en) | 2009-12-21 |
Family
ID=35864143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW92126051A TWI318629B (en) | 2002-09-20 | 2003-09-22 | Process for decreasing aggregate levels of pegylated protein |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR041350A1 (en) |
| RU (1) | RU2368619C2 (en) |
| TW (1) | TWI318629B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3641115A1 (en) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | METHOD FOR PRODUCING AN INTRAVENOUS APPLICABLE AND STABLE IN LIQUID FORM IMMUNOGLOBULINS |
| US5969109A (en) * | 1990-02-28 | 1999-10-19 | Bona; Constantin | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes |
| TW517067B (en) * | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
-
2003
- 2003-09-22 RU RU2005113152/13A patent/RU2368619C2/en active
- 2003-09-22 AR ARP030103444 patent/AR041350A1/en active IP Right Grant
- 2003-09-22 TW TW92126051A patent/TWI318629B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2368619C2 (en) | 2009-09-27 |
| AR041350A1 (en) | 2005-05-11 |
| TWI318629B (en) | 2009-12-21 |
| RU2005113152A (en) | 2005-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |