TW200500368A - Process to tetrahydrotriazolopyrazines and intermediates - Google Patents
Process to tetrahydrotriazolopyrazines and intermediatesInfo
- Publication number
- TW200500368A TW200500368A TW093105894A TW93105894A TW200500368A TW 200500368 A TW200500368 A TW 200500368A TW 093105894 A TW093105894 A TW 093105894A TW 93105894 A TW93105894 A TW 93105894A TW 200500368 A TW200500368 A TW 200500368A
- Authority
- TW
- Taiwan
- Prior art keywords
- tetrahydrotriazolopyrazines
- intermediates
- useful
- pyrazines
- triazolo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- MXILHVKNAYIRPJ-UHFFFAOYSA-N 2,3,7,7a-tetrahydro-1h-triazolo[4,5-b]pyrazine Chemical class N1C=CN=C2NNNC21 MXILHVKNAYIRPJ-UHFFFAOYSA-N 0.000 title 1
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003216 pyrazines Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45274803P | 2003-03-07 | 2003-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200500368A true TW200500368A (en) | 2005-01-01 |
Family
ID=32990678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093105894A TW200500368A (en) | 2003-03-07 | 2004-03-05 | Process to tetrahydrotriazolopyrazines and intermediates |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR043443A1 (fr) |
| TW (1) | TW200500368A (fr) |
| WO (1) | WO2004080958A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2296979T3 (es) | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Fluoropirrolidinas como inhibidores de dipeptidil peptidasa. |
| KR20050122220A (ko) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 디펩티딜 펩티다제 억제제 |
| EP1625122A1 (fr) | 2003-05-14 | 2006-02-15 | Takeda San Diego, Inc. | Inhibiteurs de dipeptidyl peptidase |
| KR20060041309A (ko) | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| EP1794120B1 (fr) | 2004-07-23 | 2012-04-11 | Nuada, LLC | Inhibiteurs de peptidase |
| PT1942898E (pt) | 2005-09-14 | 2011-12-20 | Takeda Pharmaceutical | Inibidores da dipeptidilpeptidase para o tratamento da diabetes |
| CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
| WO2007112347A1 (fr) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la dipeptidyl peptidase |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| SMT201700282T1 (it) | 2010-04-02 | 2017-07-18 | Ogeda Sa | Nuovi composti antagonisti selettivi del recetiore nk-3, composizione farmaceutica e metodi per l'uso in disturbi mediati dai recettori nk-3 |
| CN102372716A (zh) | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN101973997B (zh) * | 2010-09-30 | 2012-06-06 | 浙江大学 | 一种磷酸西他列汀侧链的制备方法 |
| CA2840814A1 (fr) | 2011-06-29 | 2013-01-03 | Ranbaxy Laboratories Limited | Dispersions solides de sitagliptine et leurs procedes de preparation |
| EP2726483A1 (fr) | 2011-06-30 | 2014-05-07 | Ranbaxy Laboratories Limited | Nouveaux sels de sitagliptine |
| SI2763992T1 (sl) | 2011-10-03 | 2016-08-31 | Euroscreen S.A. | Novi kiralni n-acil-5,6,7,(8-substituirani)-tetrahidro-(1,2,4)triazolo (4,3-a)pirazini kot selektivni nk-3 receptor antagonisti, farmacevtski sestavek, in postopki za uporabo v nk-3 posredovanih motnjah |
| WO2013084210A1 (fr) | 2011-12-08 | 2013-06-13 | Ranbaxy Laboratories Limited | Forme amorphe de sels de sitagliptine |
| EP3197876B1 (fr) | 2014-09-25 | 2018-11-28 | Ogeda Sa | Nouvelle synthèse chirale de n-acyl-(3-substituées)-(8-substituées)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines |
| EP3159343B1 (fr) | 2015-10-22 | 2017-07-19 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Procédé amélioré pour la préparation de triazole et de son sel |
| US10047094B1 (en) | 2017-02-10 | 2018-08-14 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of triazole and salt thereof |
| ES2733477T3 (es) | 2017-07-04 | 2019-11-29 | Fis Fabbrica Italiana Sintetici Spa | Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético |
| KR20200108021A (ko) * | 2018-01-09 | 2020-09-16 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Parp 억제제 및 이의 중간체의 제조 방법 |
| ES2770143T3 (es) | 2018-02-13 | 2020-06-30 | Fis Fabbrica Italiana Sintetici Spa | Nuevo procedimiento eficiente para la preparación de sitagliptina |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3252483B2 (ja) * | 1992-10-20 | 2002-02-04 | 東レ株式会社 | ３環性トリアゾロ誘導体の製造方法 |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
-
2004
- 2004-03-01 AR ARP040100646 patent/AR043443A1/es not_active Application Discontinuation
- 2004-03-03 WO PCT/US2004/006429 patent/WO2004080958A2/fr not_active Ceased
- 2004-03-05 TW TW093105894A patent/TW200500368A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004080958A2 (fr) | 2004-09-23 |
| AR043443A1 (es) | 2005-07-27 |
| WO2004080958A3 (fr) | 2004-12-23 |
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