TW200509930A - Methods and compositions for treating rheumatoid arthritis - Google Patents
Methods and compositions for treating rheumatoid arthritisInfo
- Publication number
- TW200509930A TW200509930A TW093118691A TW93118691A TW200509930A TW 200509930 A TW200509930 A TW 200509930A TW 093118691 A TW093118691 A TW 093118691A TW 93118691 A TW93118691 A TW 93118691A TW 200509930 A TW200509930 A TW 200509930A
- Authority
- TW
- Taiwan
- Prior art keywords
- methods
- compositions
- rheumatoid arthritis
- integrin
- treating rheumatoid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 3
- 108010041012 Integrin alpha4 Proteins 0.000 abstract 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960000485 methotrexate Drugs 0.000 abstract 2
- 229940122414 Alpha4 integrin antagonist Drugs 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48221103P | 2003-06-25 | 2003-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200509930A true TW200509930A (en) | 2005-03-16 |
Family
ID=33551975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093118691A TW200509930A (en) | 2003-06-25 | 2004-06-25 | Methods and compositions for treating rheumatoid arthritis |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20050074451A1 (zh) |
| EP (2) | EP1635822A4 (zh) |
| JP (2) | JP2007526230A (zh) |
| AR (1) | AR044927A1 (zh) |
| AU (2) | AU2004251750A1 (zh) |
| CA (2) | CA2528723A1 (zh) |
| CL (1) | CL2004001621A1 (zh) |
| NZ (1) | NZ544367A (zh) |
| PE (1) | PE20050232A1 (zh) |
| TW (1) | TW200509930A (zh) |
| UY (1) | UY28391A1 (zh) |
| WO (2) | WO2005000244A2 (zh) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1706399A1 (en) * | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| EP1737461B1 (en) | 2004-03-15 | 2012-12-12 | PTC Therapeutics, Inc. | Carboline derivatives useful in the inhibition of angiogenesis |
| WO2005111020A2 (en) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by vla-4 |
| AR050425A1 (es) * | 2004-07-08 | 2006-10-25 | Elan Pharm Inc | Antagonistas multivalentes de vla-4 que comprende fracciones polimericas. composiciones farmaceuticas |
| CA2588607A1 (en) | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| US20080051365A1 (en) * | 2004-12-02 | 2008-02-28 | Can-Fite Biopharma Ltd. | Treatment of Inflammation |
| ES2309817T3 (es) | 2004-12-02 | 2008-12-16 | Can-Fite Biopharma Ltd. | Tratamiento de inflamacion. |
| US20060276464A1 (en) * | 2005-05-13 | 2006-12-07 | Wyeth | Diarylsulfone sulfonamides and use thereof |
| US8030328B2 (en) | 2005-05-20 | 2011-10-04 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives |
| NZ564836A (en) * | 2005-07-08 | 2011-10-28 | Elan Pharm Inc | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
| CA2624450C (en) * | 2005-09-29 | 2014-02-04 | Elan Pharmaceuticals, Inc. | Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| WO2009055427A2 (en) * | 2007-10-22 | 2009-04-30 | Becton, Dickinson And Company | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
| JP2011528321A (ja) * | 2008-06-21 | 2011-11-17 | ケンバー,エルエルシー | ニュートリゲノミクス方法および組成 |
| HUE026406T2 (en) * | 2009-06-19 | 2016-06-28 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| CN105616410A (zh) * | 2009-07-30 | 2016-06-01 | 泰华制药工业有限公司 | 利用拉喹莫德治疗克隆氏病 |
| ES2731052T3 (es) | 2009-08-10 | 2019-11-13 | Active Biotech Ab | Tratamiento de la enfermedad de Huntington usando laquinimod |
| SG183515A1 (en) * | 2010-03-03 | 2012-10-30 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
| KR20150135552A (ko) * | 2010-03-03 | 2015-12-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| WO2011109531A1 (en) * | 2010-03-03 | 2011-09-09 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
| ES2614807T3 (es) | 2010-06-04 | 2017-06-02 | Wyeth Llc | Formulaciones vacunales |
| SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| JP2015511940A (ja) | 2012-02-03 | 2015-04-23 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 殺菌性ピリミジン化合物 |
| CA2862346A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| US9161935B2 (en) | 2012-02-03 | 2015-10-20 | Teva Pharmaceutical Industries, Ltd. | Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNF therapy |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| EP3015069A1 (en) | 2014-10-30 | 2016-05-04 | Universitätsklinikum Jena | Apparatus for suspended ultrasonography and corresponding method |
| WO2016145258A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| JP6820282B2 (ja) * | 2016-02-05 | 2021-01-27 | Eaファーマ株式会社 | スルホンアミド誘導体及びそれを含有する医薬組成物 |
| ES2797298T3 (es) | 2016-02-10 | 2020-12-01 | Becton Dickinson France | Procedimiento para evaluar la estabilidad de una formulación a base de proteína |
| WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
| JP7401864B2 (ja) * | 2018-03-05 | 2023-12-20 | 国立大学法人横浜国立大学 | ナノ微粒子、及びナノ微粒子の製造方法、並びに抗腫瘍剤 |
| WO2020046964A1 (en) | 2018-08-27 | 2020-03-05 | Sydlik Stefanie A | Chelator-functionalized glycosaminoglycans |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
| PL3873605T3 (pl) | 2018-10-30 | 2025-03-03 | Gilead Sciences, Inc. | Związki hamujące integrynę alfa4beta7 |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1080503A (en) * | 1965-07-02 | 1967-08-23 | Smith & Nephew | Substituted acetic acids and a process for their preparation |
| US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| CA2291778A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| AU8823498A (en) * | 1997-07-31 | 1999-02-22 | American Home Products Corporation | Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| IL133640A0 (en) * | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4 |
| US6489300B1 (en) * | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
| US20020198172A1 (en) * | 1997-12-01 | 2002-12-26 | Sandage Bobby W. | Method of treating motor neuron diseases and demyelinating diseases with citicoline |
| WO2000043372A1 (en) * | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat vla-4 related disorders |
| BR0007663A (pt) * | 1999-01-22 | 2002-05-07 | Elan Pharm Inc | Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4 |
| WO2001056994A1 (en) * | 2000-02-04 | 2001-08-09 | Biogen, Inc. | Integrin antagonists |
| PE20020384A1 (es) * | 2000-07-21 | 2002-05-28 | Schering Corp | PEPTIDOS COMO INHIBIDORES DE LA PROTEASA SERINA NS3/NS4a DEL VIRUS DE LA HEPATITIS C |
| PL215263B1 (pl) | 2002-02-25 | 2013-11-29 | Elan Pharm Inc | Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku |
| TW200307671A (en) * | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
-
2004
- 2004-06-25 WO PCT/US2004/020240 patent/WO2005000244A2/en not_active Ceased
- 2004-06-25 EP EP04777033A patent/EP1635822A4/en not_active Withdrawn
- 2004-06-25 NZ NZ544367A patent/NZ544367A/en unknown
- 2004-06-25 UY UY28391A patent/UY28391A1/es not_active Application Discontinuation
- 2004-06-25 JP JP2006517618A patent/JP2007526230A/ja active Pending
- 2004-06-25 US US10/875,469 patent/US20050074451A1/en not_active Abandoned
- 2004-06-25 JP JP2006517610A patent/JP2007524626A/ja active Pending
- 2004-06-25 US US10/875,282 patent/US7605166B2/en not_active Expired - Fee Related
- 2004-06-25 TW TW093118691A patent/TW200509930A/zh unknown
- 2004-06-25 CL CL200401621A patent/CL2004001621A1/es unknown
- 2004-06-25 WO PCT/US2004/020280 patent/WO2005000246A2/en not_active Ceased
- 2004-06-25 EP EP04777008A patent/EP1635871A4/en not_active Withdrawn
- 2004-06-25 PE PE2004000623A patent/PE20050232A1/es not_active Application Discontinuation
- 2004-06-25 CA CA002528723A patent/CA2528723A1/en not_active Abandoned
- 2004-06-25 AR ARP040102253A patent/AR044927A1/es unknown
- 2004-06-25 CA CA002529873A patent/CA2529873A1/en not_active Abandoned
- 2004-06-25 AU AU2004251750A patent/AU2004251750A1/en not_active Abandoned
- 2004-06-25 AU AU2004251754A patent/AU2004251754A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004251754A2 (en) | 2005-01-06 |
| CL2004001621A1 (es) | 2005-03-28 |
| CA2528723A1 (en) | 2005-01-06 |
| AR044927A1 (es) | 2005-10-12 |
| WO2005000244A3 (en) | 2005-09-29 |
| AU2004251754A1 (en) | 2005-01-06 |
| PE20050232A1 (es) | 2005-04-01 |
| AU2004251750A2 (en) | 2005-01-06 |
| CA2529873A1 (en) | 2005-01-06 |
| EP1635822A4 (en) | 2009-06-24 |
| EP1635871A2 (en) | 2006-03-22 |
| US20050065192A1 (en) | 2005-03-24 |
| WO2005000246A2 (en) | 2005-01-06 |
| NZ544367A (en) | 2009-12-24 |
| WO2005000244A2 (en) | 2005-01-06 |
| US20050074451A1 (en) | 2005-04-07 |
| EP1635871A4 (en) | 2007-07-18 |
| EP1635822A2 (en) | 2006-03-22 |
| JP2007524626A (ja) | 2007-08-30 |
| JP2007526230A (ja) | 2007-09-13 |
| UY28391A1 (es) | 2004-12-31 |
| AU2004251750A1 (en) | 2005-01-06 |
| US7605166B2 (en) | 2009-10-20 |
| WO2005000246A3 (en) | 2005-11-24 |
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