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TW200508208A - Novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione, its preparation and a depigmentation composition containing the same as an effective component - Google Patents

Novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione, its preparation and a depigmentation composition containing the same as an effective component

Info

Publication number
TW200508208A
TW200508208A TW092133158A TW92133158A TW200508208A TW 200508208 A TW200508208 A TW 200508208A TW 092133158 A TW092133158 A TW 092133158A TW 92133158 A TW92133158 A TW 92133158A TW 200508208 A TW200508208 A TW 200508208A
Authority
TW
Taiwan
Prior art keywords
same
effective component
quinazoline
phenethyl
dihydro
Prior art date
Application number
TW092133158A
Other languages
Chinese (zh)
Other versions
TWI308148B (en
Inventor
Young-Soo Kim
Sang-Hun Jung
Kyung-Rak Min
Jun-Kyu Park
Jee-Hyun Lee
Original Assignee
Young-Soo Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Young-Soo Kim filed Critical Young-Soo Kim
Publication of TW200508208A publication Critical patent/TW200508208A/en
Application granted granted Critical
Publication of TWI308148B publication Critical patent/TWI308148B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione represented by the following formula 1, a preparation method thereof, a medicinal composition for prevention and treatment of hyperpigmentation comprising the same as an effective component, and a skin-whitening cosmetic composition comprising the same as an effective component,
TW092133158A 2003-08-19 2003-11-26 Novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione, its preparation and a depigmentation composition containing the same as an effective component TWI308148B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020030057135A KR100747042B1 (en) 2003-08-19 2003-08-19 New substance 6-methyl-3-phenethyl-3,4-dihydro-lH-quanazoline-2-thione, preparation method thereof and a whitening effect composition comprising the same as an active ingredient

Publications (2)

Publication Number Publication Date
TW200508208A true TW200508208A (en) 2005-03-01
TWI308148B TWI308148B (en) 2009-04-01

Family

ID=34192126

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092133158A TWI308148B (en) 2003-08-19 2003-11-26 Novel compound of 6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione, its preparation and a depigmentation composition containing the same as an effective component

Country Status (4)

Country Link
KR (1) KR100747042B1 (en)
AU (1) AU2003282429A1 (en)
TW (1) TWI308148B (en)
WO (1) WO2005016895A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107920652A (en) * 2015-08-24 2018-04-17 阿莫生命科学有限公司 Beauty mask and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101104307B1 (en) * 2009-07-10 2012-01-11 충북대학교 산학협력단 Novel dihydro quinazoline-2-thione derivatives and whitening compositions containing them
US8476251B2 (en) 2010-07-29 2013-07-02 Conopco, Inc. Skin care compositions comprising substituted diamines
US8293218B2 (en) 2010-07-29 2012-10-23 Conopco, Inc. Skin care compositions comprising substituted monoamines
US20130273183A1 (en) * 2012-04-13 2013-10-17 Eastman Chemical Company 2-Pyrimidine Thioesters and Thiocarbonates as Skin Brightening Agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3077046B2 (en) * 1992-08-31 2000-08-14 久光製薬株式会社 New quinazoline derivatives
US6750229B2 (en) * 1998-07-06 2004-06-15 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin pigmentation
JP4249855B2 (en) * 1999-08-31 2009-04-08 実 土屋 Moving bed type filtration equipment using floating media
DE10008907A1 (en) * 2000-02-25 2001-08-30 Haarmann & Reimer Gmbh Topical cosmetic compositions containing benzocondensed or heterocyclically condensed 2-hydrazino-1,3-heteroazoles
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107920652A (en) * 2015-08-24 2018-04-17 阿莫生命科学有限公司 Beauty mask and preparation method thereof

Also Published As

Publication number Publication date
TWI308148B (en) 2009-04-01
KR100747042B1 (en) 2007-08-07
AU2003282429A1 (en) 2005-03-07
KR20050019401A (en) 2005-03-03
WO2005016895A1 (en) 2005-02-24

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees