TW200508195A - 3-aminopyrrolidines as inhibitors of monoamine uptake - Google Patents
3-aminopyrrolidines as inhibitors of monoamine uptakeInfo
- Publication number
- TW200508195A TW200508195A TW093115543A TW93115543A TW200508195A TW 200508195 A TW200508195 A TW 200508195A TW 093115543 A TW093115543 A TW 093115543A TW 93115543 A TW93115543 A TW 93115543A TW 200508195 A TW200508195 A TW 200508195A
- Authority
- TW
- Taiwan
- Prior art keywords
- aminopyrrolidines
- inhibitors
- monoamine uptake
- uptake
- monoamine
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0313463A GB0313463D0 (en) | 2003-06-11 | 2003-06-11 | Inhibitors on monoamine uptake |
| US51086703P | 2003-10-14 | 2003-10-14 | |
| US52445003P | 2003-11-24 | 2003-11-24 | |
| US52478103P | 2003-11-25 | 2003-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200508195A true TW200508195A (en) | 2005-03-01 |
Family
ID=33556507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093115543A TW200508195A (en) | 2003-06-11 | 2004-05-31 | 3-aminopyrrolidines as inhibitors of monoamine uptake |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7619096B2 (zh) |
| EP (1) | EP1638934B1 (zh) |
| AR (1) | AR044570A1 (zh) |
| AT (1) | ATE383335T1 (zh) |
| DE (1) | DE602004011221T2 (zh) |
| ES (1) | ES2298782T3 (zh) |
| PE (1) | PE20050160A1 (zh) |
| SV (1) | SV2005001805A (zh) |
| TW (1) | TW200508195A (zh) |
| WO (1) | WO2005000811A1 (zh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2345261T3 (es) | 2004-02-27 | 2010-09-20 | Eli Lilly And Company | Derivados de 4-amino-piperidina como inhibidores de la captacion de monoamina. |
| US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
| US7615648B2 (en) | 2004-06-01 | 2009-11-10 | Eli Lilly And Company | Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| US9040558B2 (en) | 2004-12-31 | 2015-05-26 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| TWI410406B (zh) * | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
| GB0701171D0 (en) * | 2007-01-22 | 2007-02-28 | Imp Innovations Ltd | Compositions and uses thereof |
| EP2974724A1 (en) | 2009-02-09 | 2016-01-20 | Sunovion Pharmaceuticals Inc. | Pyrrolidine triple reuptake inhibitors |
| JP5714580B2 (ja) | 2009-07-21 | 2015-05-07 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ３−フェノキシメチルピロリジン化合物 |
| US9199967B2 (en) | 2011-08-18 | 2015-12-01 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors |
| IN2014CN02290A (zh) | 2011-09-27 | 2015-06-19 | Reddys Lab Ltd Dr | |
| WO2014018721A1 (en) | 2012-07-25 | 2014-01-30 | Bio-Rad Laboratories, Inc. | Targeted delivery of reagents through patterned transfer sheets |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6353008B1 (en) * | 1998-06-30 | 2002-03-05 | Eli Lilly And Company | Pyrrolidine and pyrroline derivatives having effects on serotonin related systems |
| CA2348879A1 (en) | 1998-11-02 | 2000-05-11 | Welfide Corporation | Pyrrolidine compound and pharmaceutical use thereof |
| HK1049004A1 (zh) * | 2000-01-20 | 2003-04-25 | Eisai Co., Ltd. | 含氮的环状化合物和含有该化合物的药用组合物 |
| CA2397981C (en) * | 2000-03-06 | 2010-12-21 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
| JP4619655B2 (ja) * | 2001-09-14 | 2011-01-26 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体 |
| MXPA04012893A (es) * | 2002-06-24 | 2005-03-31 | Acadia Pharm Inc | Derivados de piperidina n-substituidos como agentes receptores de serotonina. |
| SI1556045T1 (sl) * | 2002-10-04 | 2007-02-28 | Ucb Sa | Derivati 4-aminopiperidina, postopek izdelave in uporaba v medicini |
| AU2003290735A1 (en) * | 2002-12-06 | 2004-06-30 | Eli Lilly And Company | Inhibitors of monoamine uptake |
-
2004
- 2004-05-11 US US10/558,626 patent/US7619096B2/en not_active Expired - Fee Related
- 2004-05-11 WO PCT/US2004/013004 patent/WO2005000811A1/en not_active Ceased
- 2004-05-11 EP EP04750759A patent/EP1638934B1/en not_active Expired - Lifetime
- 2004-05-11 ES ES04750759T patent/ES2298782T3/es not_active Expired - Lifetime
- 2004-05-11 AT AT04750759T patent/ATE383335T1/de not_active IP Right Cessation
- 2004-05-11 DE DE602004011221T patent/DE602004011221T2/de not_active Expired - Fee Related
- 2004-05-28 AR ARP040101856A patent/AR044570A1/es unknown
- 2004-05-28 PE PE2004000546A patent/PE20050160A1/es not_active Application Discontinuation
- 2004-05-31 TW TW093115543A patent/TW200508195A/zh unknown
- 2004-06-11 SV SV2004001805A patent/SV2005001805A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005000811A1 (en) | 2005-01-06 |
| EP1638934A1 (en) | 2006-03-29 |
| ES2298782T3 (es) | 2008-05-16 |
| EP1638934B1 (en) | 2008-01-09 |
| PE20050160A1 (es) | 2005-03-26 |
| DE602004011221T2 (de) | 2009-01-02 |
| AR044570A1 (es) | 2005-09-21 |
| DE602004011221D1 (de) | 2008-02-21 |
| ATE383335T1 (de) | 2008-01-15 |
| SV2005001805A (es) | 2005-11-04 |
| US7619096B2 (en) | 2009-11-17 |
| US20060270713A1 (en) | 2006-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1940839E (pt) | Inibidores de piridopirimidinona pi3k alfa | |
| NO2020031I1 (no) | kobimetinib, inklusive farmasøytisk akseptable salter og solvater, særlig kobimetinib hemifumarat | |
| MX2009005604A (es) | Inhibidores espiro cetona de acetil-coa carboxilasa. | |
| MXPA06000013A (es) | Agente terapeutico para sarcoma de tejido suave. | |
| TW200508195A (en) | 3-aminopyrrolidines as inhibitors of monoamine uptake | |
| MX2010002258A (es) | Compuestos terapeuticos de isoxazol. | |
| DK1506185T3 (da) | Forbindelser og deres anvendelse som 5-HT-inhibitorer | |
| NO20081554L (no) | Isoindollmidforbindelser og sammensetninger omfattende samme, og anvendelse derav | |
| MY162157A (en) | Substituted indole mcl-1 inhibitors | |
| MX368368B (es) | Compuestos de indol e indazol como un inhibidor de necrosis celular. | |
| UA94964C2 (ru) | Производные 5-замещенного хиназолинона, композиция, которая их содержит, и их применение | |
| MY180812A (en) | 4'-o-substituted isoindoline derivattives and compositions comprising and methods of using the same | |
| PL369108A1 (en) | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | |
| TNSN08191A1 (en) | Kinase inhibitors | |
| TW200736229A (en) | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | |
| MXPA05009303A (es) | Formas de dosificacion y procedimientos de tratamiento que usan inhibidores del vegfr. | |
| MXPA05011176A (es) | Derivados de carboxamida como agentes antidiabeticos. | |
| WO2006057922A3 (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment | |
| UA97348C2 (en) | HETEROCYCLIC NF-kB INHIBITORS | |
| WO2004052858A3 (en) | Inhibitors of monoamine uptake | |
| IL188927A0 (en) | Aryloxy quinolines and uses thereof as 5-ht6 modulators | |
| PL1845780T3 (pl) | Zastosowanie pochodnych metylofenidatu | |
| EA201000720A1 (ru) | 4,4-дизамещённые пиперидины как ингибиторы ренина | |
| WO2006133339A3 (en) | Monoamine re-uptake inhibitors and methods relating thereto | |
| MY141048A (en) | Morpholine derivatives as norepinephrine reuptake inhibitors |