TW200507848A - Hiv integrase inhibitors - Google Patents
Hiv integrase inhibitorsInfo
- Publication number
- TW200507848A TW200507848A TW093111823A TW93111823A TW200507848A TW 200507848 A TW200507848 A TW 200507848A TW 093111823 A TW093111823 A TW 093111823A TW 93111823 A TW93111823 A TW 93111823A TW 200507848 A TW200507848 A TW 200507848A
- Authority
- TW
- Taiwan
- Prior art keywords
- optionally
- polysubstituted
- optionally polysubstituted
- polysusbstituted
- het2
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46598703P | 2003-04-28 | 2003-04-28 | |
| EP03101164 | 2003-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200507848A true TW200507848A (en) | 2005-03-01 |
Family
ID=33420586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093111823A TW200507848A (en) | 2003-04-28 | 2004-04-28 | Hiv integrase inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060211724A1 (zh) |
| EP (1) | EP1625130A2 (zh) |
| KR (1) | KR20060006047A (zh) |
| CN (1) | CN1812992A (zh) |
| AP (1) | AP2005003451A0 (zh) |
| AR (1) | AR044518A1 (zh) |
| AU (1) | AU2004234087A1 (zh) |
| BR (1) | BRPI0409873A (zh) |
| CA (1) | CA2522990A1 (zh) |
| MX (1) | MXPA05011726A (zh) |
| NO (1) | NO20055230L (zh) |
| TW (1) | TW200507848A (zh) |
| WO (1) | WO2004096807A2 (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006125048A2 (en) * | 2005-05-16 | 2006-11-23 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| JP5289046B2 (ja) | 2005-05-19 | 2013-09-11 | メルク カナダ インコーポレイテッド | Ｅｐ４アンタゴニストとしてのキノリン誘導体 |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| CA2616314A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
| WO2007076005A2 (en) * | 2005-12-21 | 2007-07-05 | Gilead Sciences, Inc. | Processes and intermediates useful for preparing integrase inhibitor compounds |
| NZ572367A (en) * | 2006-05-16 | 2011-09-30 | Gilead Sciences Inc | Fused cyclic compounds as integrase inhibitors |
| EP1916249A1 (en) * | 2006-10-10 | 2008-04-30 | LEK Pharmaceuticals D.D. | 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents |
| DK2124562T3 (en) | 2007-03-09 | 2016-08-01 | Second Genome Inc | BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof |
| US20090291921A1 (en) * | 2007-11-20 | 2009-11-26 | Gilead Sciences, Inc. | Integrase inhibitors |
| MX2010008148A (es) | 2008-01-25 | 2010-10-20 | Chimerix Inc | Métodos de tratamiento de infecciones virales. |
| JP5628145B2 (ja) | 2008-03-19 | 2014-11-19 | ケムブリッジ・コーポレーション | 新規チロシンキナーゼ阻害剤 |
| US8822500B2 (en) | 2008-03-19 | 2014-09-02 | Chembridge Corporation | Tyrosine kinase inhibitors |
| US9249147B2 (en) | 2008-03-19 | 2016-02-02 | Chembridge Corporation | Tyrosine kinase inhibitors |
| KR20120034592A (ko) * | 2009-04-09 | 2012-04-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｈｉｖ 복제의 저해제 |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| WO2011100698A2 (en) | 2010-02-12 | 2011-08-18 | Chimerix, Inc. | Methods of treating viral infection |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| EP3830093A1 (en) | 2018-07-27 | 2021-06-09 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| EP1326610B1 (en) * | 2000-10-12 | 2006-11-15 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| WO2004035577A2 (en) * | 2002-10-16 | 2004-04-29 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| US7442773B2 (en) * | 2004-01-23 | 2008-10-28 | The Board Of Trustees Of The University Of Illinois | Universal peptide-binding scaffolds and protein chips |
-
2004
- 2004-04-27 US US10/554,712 patent/US20060211724A1/en not_active Abandoned
- 2004-04-27 BR BRPI0409873-0A patent/BRPI0409873A/pt not_active IP Right Cessation
- 2004-04-27 AU AU2004234087A patent/AU2004234087A1/en not_active Abandoned
- 2004-04-27 EP EP04741485A patent/EP1625130A2/en not_active Withdrawn
- 2004-04-27 WO PCT/EP2004/050621 patent/WO2004096807A2/en not_active Ceased
- 2004-04-27 CA CA002522990A patent/CA2522990A1/en not_active Abandoned
- 2004-04-27 AP AP2005003451A patent/AP2005003451A0/xx unknown
- 2004-04-27 KR KR1020057020004A patent/KR20060006047A/ko not_active Withdrawn
- 2004-04-27 CN CNA2004800180526A patent/CN1812992A/zh active Pending
- 2004-04-27 MX MXPA05011726A patent/MXPA05011726A/es unknown
- 2004-04-28 AR ARP040101446A patent/AR044518A1/es not_active Application Discontinuation
- 2004-04-28 TW TW093111823A patent/TW200507848A/zh unknown
-
2005
- 2005-11-07 NO NO20055230A patent/NO20055230L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20055230L (no) | 2005-11-07 |
| WO2004096807A3 (en) | 2005-01-06 |
| BRPI0409873A (pt) | 2006-05-16 |
| CN1812992A (zh) | 2006-08-02 |
| WO2004096807A2 (en) | 2004-11-11 |
| AU2004234087A1 (en) | 2004-11-11 |
| US20060211724A1 (en) | 2006-09-21 |
| MXPA05011726A (es) | 2006-01-23 |
| WO2004096807A8 (en) | 2005-09-22 |
| EP1625130A2 (en) | 2006-02-15 |
| AP2005003451A0 (en) | 2005-12-31 |
| CA2522990A1 (en) | 2004-11-11 |
| AR044518A1 (es) | 2005-09-14 |
| KR20060006047A (ko) | 2006-01-18 |
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