TW200404716A - Delivery device and container provided with the same - Google Patents

Abstract

The present invention provides a delivery device that delivers a liquid contained in a flexible container when the container is depressed, and the container that has the delivery device attached to the mouth thereof. The delivery device comprises an outlet portion having substantially bottomed tubular shape or substantially bowl like shape that has an outlet orifice at the bottom thereof, a valve element made of an elastic material that, when there is no liquid pressure exerting thereon, closes the outlet orifice and/or a flow passage that communicates with the outlet orifice in the outlet portion and, when a liquid pressure is exerted thereon, deforms so as to open the outlet orifice and/or the flow passage, and a vent hole that communicates with the outlet orifice and the flow passage via an air filter, wherein deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, and opening of the outlet orifice and/or the flow passage cannot be achieved by the pressure required to pass air through the air filter from outside.

Description

200404716 (1) 发明. Description of the invention. [Technical field to which the invention belongs] The present invention relates to a conveying device which is used to convey a liquid contained in the container when a container is pressed, and the container is provided with the conveying device. [Prior Art] A container, such as an eye dropper, used to drip the liquid contained therein utilizes a transfer device 150 as shown in Figs. 41 (a) and (b). The transfer device 150 is installed at the mouth 152a of the container body 152. The container body 150 has an outlet hole 151. The inner diameter is set so that it can transfer liquid by pressing the container body 152, and when the container body 152 is not pressed, As a result, the liquid is not transferred, and a one-size outlet opening 1 3 is set to hold the liquid in the form of droplets 154. The container shown in Fig. 41 has a high possibility that the outlet opening 153 is contaminated with microorganisms such as bacteria and dust. Taking an eye dropper as an example, in particular, it is very possible for the exit opening 1 5 3 to obtain the microorganisms through contact with the cornea and / or eyelid. After the liquid is transferred from this container, the outside air enters through the outlet opening 153 to restore the compressed body 152 to its original shape. During this period, microorganisms and dust that have been captured on the outlet opening 153 may be damaged. This liquid (ophthalmic solution) was carried 1 5 5 and this liquid has been left in the outlet opening and returned to the container body 152, as shown in Figs. 42 (a) and (b). Reference numeral 156 in Fig. 42 (b) indicates air bubbles in the liquid (ophthalmic solution) 155. Because the entry of microorganisms and dust into the container may cause the liquid contained in -4-(2) 200404716 to degrade or deteriorate, disinfectants contained in eye drops such as ammonium phthalate and p-hydroxybenzene are present. There are problems in that it is difficult to determine the components of the sterilizer according to the eye, and the sterilizer can cause allergic side effects to the eye drops. To this end, avoid or reduce the use of disinfectants. For example, a small amount of ophthalmic solution without eyedrops has been sold on the market for some time. Although in addition to the use of disinfectants, high costs limit their use. Japan's first published patent application No. 2002 · A transmission device equipped with a filter. This filter uses a layered bottle on the inner layer. The inner layer can be arranged in layers on the body. The transmission device prevents the outside air container. The liquid in the container is exposed to bacteria or the like. However, it is necessary to provide an inner container which is easily deformed in order to accommodate the change in the transmission force of the liquid, which leads to an increase in the manufacturing cost of the container. Japanese Prior Patent Application No. 2001 · Japanese Patent Application No. 200 1 — 206454 Antibacterial container with a hole filter, this filter has holes for small dust to pass through, and is installed at its outlet opening. Porous filter may be the solution contained in the body after the liquid is wetted. A suspension can be added depending on the ophthalmic solution. However, the type of potion is used to refer to eye drops that can cause disposable drops of disinfectants such as user reasons, and efforts have been made to dispose of them. It is prohibited to widely disclose the so-called having an outer layer and an outer layer on 80055. . The contamination of bacteria flowing into the liquid through the outlet opening can be prevented. The internal pressure of the container caused by the inner layer of the container is established. Nos. -1 790 1 7 and Japanese Patent No. 1 have enough to prevent bacteria and bacteria. In this example, however, the filter is filled with liquid and used as an eye solution. In this example, the problem of the filter is more likely to occur. Furthermore, 'However, the containers disclosed in Japanese Prior Laid-Open Patent Application No. 200 1-1 790 1 7 and Japanese Prior Laid-Open Patent Application No. 200 1-206454 utilize a container made of sintered metal or sintered resin. Porous filter 'In this example, fine particles of the sintered material may be transferred along with the liquid. [Summary of the Invention]

Against this background, the object of the present invention is to provide a transfer device that is installed at the mouth of a container and transfers the liquid contained therein in the form of droplets, which can prevent this liquid from flowing back, and, after transferring the liquid, achieves Air enters the container aseptically. Another object of the present invention is to provide a container, which can remove or reduce the use of antibacterial agents for the purpose of preventing the degradation or deterioration of the contained liquid, and achieves the smooth transfer of the liquid, even when the contained liquid system suspension, Does not block the exit opening.

[Conveying Device] The conveying device of the present invention, which achieves the above-mentioned object, includes: an outlet portion 'having a substantially bottomed tube shape or a substantially bowl shape, the shape having an outlet hole at its bottom; a valve element, which is elastic Made of material, when no liquid pressure is applied to it from the upstream side, the flow path in the outlet hole and / or the outlet portion communicating with the outlet hole is closed, and when liquid pressure is applied from the upstream side to When it is on top of it, deform and open the outlet hole and / or flow path, the side of the outlet hole is defined as downstream, and the ventilation hole is connected with the outlet hole-6-(4) (4) 200404716, the outlet hole system An air filter is provided upstream of the valve element, wherein the deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the outlet hole and / or the flow The opening of the road cannot be achieved from the outside by the air passage pressure of the air filter. In the conveying device of the present invention, the valve element controlling the opening and closing of the outlet hole and the flow path is made of an elastic material, and when there is no liquid pressure extending from the upstream side to the upper side, the outlet hole and / or the flow is closed. And when the liquid pressure is compressed from the upstream side, the outlet hole and / or the flow path is deformed and opened, and when the outlet hole and / or the flow path is opened, the outlet side and the upstream side of the outlet part (especially such as The container body of the eye dropper connected to the conveying device of the present invention becomes interconnected to communicate with each other, thereby achieving the transfer of liquid from the outlet hole. Applied to a container body such as an eye dropper, the container system is connected to a transfer device. When the pressure is applied, the valve element of the transfer device receives the pressure (liquid for medical use or the like) containing the liquid from the upstream side, so that the valve element is deformed, and the outlet hole and / or the flow path is opened. After the transfer operation is completed, the deformed container body sucks in external air through the ventilation holes in order to restore the original shape. When the conveying device of the present invention is used, since the air filter is installed in the ventilation hole communicating with the flow path containing the liquid, the aseptic entry of the air into the container can be achieved after the conveying operation. Negative pressure 'is generated in the container body connected to the transfer device so that the outside air is sucked in after completion of the transfer operation, and has the effect of accelerating the recovery of the deformed valve element (5) 200404716. As a result, when the pressure on the container body is removed, the gap (flow path) formed by the transfer operation between the valve element and the outlet portion is immediately closed, and therefore, the valve element in the transfer device of the present invention acts as one Back to the valve. The transfer device of the present invention can be implemented as described in the following first to fifth embodiments.

(First Embodiment)

A first conveying device according to the present invention includes: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at the bottom thereof; and a valve element made of an elastic material and disposed at the outlet. When the liquid pressure is applied from the upstream side, the outlet hole is closed, and when the liquid pressure is applied from the upstream side, it encounters compression deformation and opens the outlet hole. The side is defined as downstream; the locking member is' disposed at the outlet portion to define a flow path between itself and the inner surface of the outlet portion 'and fix the valve element upstream; and a vent hole communicating with the outlet hole' the The outlet hole is provided at a position of ± of the valve element through an air filter, wherein the compression deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the outlet The opening of the holes and / or the flow path cannot be achieved from the outside by the air passage pressure of the air filter. In the first conveying device, a valve element made of an elastic material and disposed at an outlet portion is operated in relation to an outlet hole as a valve seat to control closing and opening of a flow path. When there is no liquid pressure extending from the upstream side to it, the valve-8- (6) (6) 200404716 element closes the outlet hole, and when the liquid pressure is compressed from the upstream side, compression deformation is performed to open the outlet hole, When the outlet hole is opened, the outlet hole and the flow path formed between the inner surface of the outlet portion and the locking member communicate with each other, so that the contained liquid is transferred from the outlet portion. In the first transfer device, the transfer of liquid from the outlet hole can be achieved by applying a pressure to the container body, and the container system is connected to a transfer device similar to the aforementioned one. Such characteristics and operations are similar to the aforementioned characteristics and operations. When the valve element returns to its original shape after the transfer operation, the aseptic access of the air through the air filter can be achieved, and the negative pressure of the external air is accelerated. Recovery of a deformed valve element (thereby, the valve element can be caused to act like a check valve). In the first transfer device, since the compression deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, the liquid in the air filter does not leak out during the transfer operation. In the meantime, because the opening of the outlet hole and / or the flow path communicating with the outlet hole cannot be achieved by the pressure required for air to pass from the outside through the air filter, no outside air will pass through the outlet hole and not through the filter. The entry of the liquid does not occur during the recovery period of the container through the corresponding leakage of the outlet hole. As a result, according to the first conveying device of the present invention, the conveying operation and recovery of the container body after the conveying operation can be smoothly achieved, and at a high level, the backflow of liquid that has been conveyed from the outlet hole and the microorganisms carried from the liquid to the upstream are prevented And the ingress of dust. -In the first conveying device, the valve element and the locking member are preferably formed as a whole 1 -9-(7) 200404716. By integrally forming the valve element and the locking member, the manufacturing process of the transfer device can be made efficient. Methods for integrally forming the valve element and the locking member include, for example, multi-color molding and insert molding. [Second Embodiment]

A second conveying device according to the present invention includes: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at the bottom thereof; a valve seat fixed to the outlet portion; a valve element, Made of a substantially tubular material with an elastic material, the valve element is fixed on the inner surface of the outlet portion, and when no liquid pressure is applied thereto, it contacts from the downstream side through the valve seat to close the flow communicating with the outlet hole. And when a liquid pressure is applied to it from the upstream side, compressive deformation is performed to open the flow path between itself and the valve seat, the outlet hole side is defined as a downstream; and a vent hole communicates with the outlet hole The outlet hole is provided upstream of the valve element via an air filter, wherein the compression deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and, The opening of the outlet hole and / or the flow path cannot be achieved from the outside by the air passage pressure of the air filter. In the second transfer device, a valve element made of an elastic material and arranged at the outlet portion is paired with a valve seat also arranged at the outlet portion to control the closing and opening of the flow path. When no liquid pressure extends from the upstream side to the upper side, the valve element is in contact with the valve seat, and the flow path connecting the outlet hole and the upstream side of the outlet portion is closed. When the liquid pressure is compressed from the upstream side, the valve element undergoes compression deformation and forms a gap between itself and the valve seat (opens a gap between itself 0.24 -10- (8) (8) 200404716 and the valve seat between). Therefore, a gap is formed between the valve element and the valve seat, and a flow path is formed to communicate between the upstream of the valve element and the outlet hole, thereby achieving the liquid transmission from the outlet hole. In the second transfer device, the transfer of liquid from the outlet hole can be achieved by applying a pressure to the container body, and the container system is connected to a transfer device similar to that described above. Such characteristics and operations are similar to the foregoing characteristics and operations. 'When the valve element returns to its original shape after the transfer operation, aseptic access to the container through the air filter air can be achieved, and the negative pressure sucked into the outside air is accelerated. Recovery of a deformed valve element (thereby, the valve element can be caused to act like a check valve). In the second transfer device, since the compression deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, no leakage of the liquid through the vent hole occurs during the transfer operation. In the meantime, because the opening of the outlet hole and / or the flow path communicating with the outlet hole cannot be achieved by the pressure required to allow air to pass from the outside through the air filter, no outside air will pass through the outlet hole instead of the filter. During the entry, the corresponding leakage of liquid through the outlet hole does not occur during the recovery period of the container body. As a result, according to the second conveying device of the present invention, the conveying operation and recovery of the container body after the conveying operation can be smoothly achieved, and at the same time, the backflow of the liquid that has been conveyed from the outlet hole and the microorganisms carried from the liquid to the upstream can be prevented. And the ingress of dust. In the second conveying device, the valve element is fixed to the inner surface of the outlet portion for the purpose of accurately closing and opening the flow path. Therefore, the valve element… 11-(9) (9) 200404716 and the locking member are preferably integrally formed, but this structure is not limited. By integrally forming the valve element and the locking member, the process of manufacturing the transfer device can be more efficient. Methods for integrally forming the valve element and the locking member include, for example, multi-color molding and insert molding. [Third Embodiment] A third transfer device according to the present invention includes: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at the bottom thereof; and a valve element made of an elastic material It is arranged at the outlet portion, and when no liquid pressure is applied to it from the upstream side, the outlet hole or the flow channel communicating with the outlet hole is closed, and when liquid pressure is applied to it from the upstream side Expansion expansion to open the outlet hole or flow path, the side of the outlet hole is defined as downstream; and a vent hole communicating with the outlet hole, the outlet hole is provided upstream of the valve element through an air filter Position, wherein the expansion deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the opening of the outlet hole and / or the flow path cannot be opened from the outside by the air filter The air is reached by pressure. In the third transfer device, a valve element made of an elastic material and arranged at the outlet portion controls closing and opening of the outlet hole or the flow path. When no liquid pressure extends from the upstream side to it, the valve element closes the outlet hole or the flow path communicating with the outlet hole, and when the liquid pressure is compressed from the upstream side, it expands and deforms and opens the outlet hole or flow. road. When the outlet hole or flow path is opened, the upstream of the outlet element and the flow path between the outlet holes are established to communicate with each other, so that 8-26 -12-(10) (10) 200404716 liquid is transferred from the outlet hole. In the third transfer device, the transfer of liquid from the outlet hole can be achieved by applying a pressure to the 'container body' and the container system is connected to a transfer device similar to the aforementioned one. This characteristic and operation is also similar to the foregoing characteristics and operation, in which when the valve element returns to its original shape after the transfer operation, 'the aseptic access of the air through the air filter can be achieved' and the negative pressure of the external air is accelerated Recovery of a deformed valve element (hence the 'valve element can be caused to act like a check valve). In the third transfer device, since the swelling deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, no leakage of liquid in the vent hole occurs during the transfer operation . In the meantime, because the expansion deformation of the valve element is not caused by the external pressure according to this structure (therefore, the expansion deformation cannot be achieved by a pressure equal to the air pressure from the outside through the air filter), it will not occur The outside air enters through the outlet hole instead of the ventilation hole, and the corresponding leakage of the liquid through the outlet hole does not occur during the recovery period of the container body. As a result, according to the third conveying device of the present invention, the conveying operation and recovery of the container after the conveying operation can be smoothly achieved, and at the same time, at a high level, the backflow of liquid that has been conveyed from the outlet hole and the microorganisms and liquids carried upstream from the liquid and Ingress of dust. In the third transfer device of the present invention, the valve element has a valve body fixed to the flow path, and a convex portion formed at an end on the outlet hole side thereof. The convex portion located at the tip of the valve body engages from the upstream with a ridge formed on the inner wall of the flow path to close the flow path, and the ridge is in communication with the outlet hole. -13- (11) 200404716 The valve body preferably expands from the upstream side toward the downstream under the effect of liquid pressure, so as to form a gap on the convex portion of the tip of the valve body and the inner surface of the flow path Between the spines.

In this example, when no liquid pressure extends from the upstream side to the upper side, the convex portion at the tip of the valve body engages with the ridge portion provided on the inner surface of the flow path from the downstream side, so that the flow path is closed. . When liquid pressure is applied, the valve element expands toward the downstream of the engagement position, thereby opening a gap between a convex portion located at the tip of the valve body and a ridge portion provided on the inner surface of the flow path. When the transfer operation is completed and the liquid pressure is removed from the valve element, when the valve element returns to its original shape, the convex portion located at the tip of the valve body returns upstream to reconnect with the ridge provided on the inner surface of the flow path. The parts are engaged, thereby closing the flow path. The recovery of the deformed valve element is accelerated by the negative pressure, which is generated by the recovery of the container body which has been deformed by the conveying operation, and has the effect of sucking the outside air as described above.

[Fourth Embodiment] A fourth conveying device according to the present invention includes an outlet portion having a substantially bottom tube shape or a substantially bowl shape, the shape having an outlet hole at its bottom; a valve element, made of an elastic material Made and in contact with the outlet on its outer surface, when no liquid pressure is applied to it from the upstream side, close the outlet hole, and when liquid pressure is applied to it from the upstream side Inflated and deformed to open the outlet hole or flow path, the side of the outlet hole is defined as a downstream; and a vent hole communicating with the outlet hole, the outlet hole is provided upstream of the valve element through an air filter, The expansion element of the valve element -14- (12) (12) 200404716 is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the opening of the outlet hole cannot be opened from the outside by The air of the air filter is achieved by pressure. In the fourth conveying device, a valve element made of an elastic material and arranged to contact an outlet portion on its outer surface controls the closing and opening of the outlet hole. When there is no liquid pressure extending from the upstream side to the upper side, the valve element closes the outlet hole, and when the liquid pressure is compressed from the upstream side, the expansion deformation (toward The valve element is bent outside), and the outlet hole is opened. When the outlet hole is opened, the upstream side of the outlet element and the flow path between the outlet holes are established to communicate with each other, so that the liquid is transferred from the outlet hole. In the fourth transfer device, the transfer of liquid from the outlet hole can be achieved by applying a pressure to the container body, and the container system is connected to a transfer device similar to that described above. Such characteristics and operations are similar to the aforementioned characteristics and operations. When the valve element returns to its original shape after the transfer operation, the aseptic access of the air through the air filter can be achieved, and the negative pressure of the external air is accelerated. Recovery of a deformed valve element (thereby, the valve element can be caused to act like a check valve). In the fourth conveying device, since the swelling deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, no leakage of liquid in the vent hole occurs during the conveying operation. . In the meantime, because the expansion deformation of the valve element is not caused by the external pressure according to this structure (therefore, the expansion deformation cannot be achieved by the eyebrow force equal to the air pressure from the outside through the air filter), it will not When the external air i -15- (13) (13) 200404716 enters through the outlet hole instead of the ventilation hole, the corresponding leakage of liquid through the outlet hole will not occur during the recovery period of the container body. As a result, according to the fourth conveying device of the present invention, the conveying operation and recovery of the container after the conveying operation can be smoothly achieved, and at the same time, at a high level, the backflow of liquid that has been conveyed from the outlet hole and the microorganisms and Ingress of dust. In the fourth transfer device of the present invention, the outlet hole is defined by a substantially dish-shaped valve seat fixed to the outlet portion and an inner wall surface of the outlet portion holding the valve seat. However, the valve element has a substantially annular shape. The thin-walled portion is brought into contact with the valve seat by bringing the thin-walled portion from the outer surface side of the outlet portion to close the outlet hole. The thin-walled portion of the valve element is preferably expanded and deformed toward the downstream under liquid pressure to open the outlet hole, and the outlet hole side is defined as downstream. In this example, when no liquid pressure extends from the upstream side to the upper side, the thin-walled portion of the valve element comes into contact with the substantially disc-shaped valve seat to close the outlet hole. When liquid pressure is applied, the valve element expands and deforms toward the downstream (bends to the outside of the outlet portion), thereby opening the outlet hole defined between the substantially disc-shaped valve seat and the inner wall surface of the outlet portion. Hold the valve seat. When the transfer operation is completed and the liquid pressure is removed from the valve element, the thin-walled portion of the valve element comes into contact with the substantially disc-shaped valve seat again to close the flow path. The recovery of the deformed valve element is accelerated by the negative pressure, which has the effect of sucking in the outside air, and is generated by the recovery of the container body, which has been deformed by the conveying operation, as described above. In the fourth transfer device of the present invention, the valve element is preferably integrally formed outside the outlet portion, which makes the process of manufacturing the transfer device more efficient. Use -16 · (14) 200404716 to form the valve element and make it as a whole, but these are not restricted. [Fifth embodiment] The fifth substantially bottom tube or substantially bottom according to the present invention; a valve element, The body and a substantially annular thin wall are at the exit portion, but the thin wall; a cylindrical valve element supporting hole and the valve element; and the side of the hole is defined as a downstream through an air filter, and the outer periphery of its supporting member When the contact is made, the outlet hole is closed so that when the liquid pressure is applied to its expansion and deformation, it is achieved by the air below, and the air of the outlet filter passes the pressure and the valve element in the fifth conveying device has its thickness. The wall portion is exposed between the outside valve element supporting members of the outlet portion. As the valve seat, methods for controlling the outlet orifice portion include multi-color molding and insertion molding. The conveying device includes: an outlet portion having a floor bowl shape, the shape having an outlet hole made of a material of its nature and having a substantially annular valve portion provided at the tip of the former, the valve system fixing portion passing through the The hole is exposed to the outer member of the outlet portion, and is arranged on the outlet portion to define an outlet air hole, which is in communication with the outlet hole. The outlet hole is provided upstream of the valve element, and the valve element in the outlet makes the thin-walled part of the The valve element is such that when no liquid pressure is applied from the upstream side, but the thin-walled portion is expanded and deformed, the outlet hole is opened at the above time, and the liquid pressure hole of the thin-walled expanded filter cannot be opened by the pressure of the liquid pressure hole. This is achieved from the outside by this air passage. It is made of an elastic material and arranged in the exit portion and fixed to a hole provided at the bottom of the exit portion to define the opening and closing of the exit hole itself and the thin-walled portion 1 using a round valve element supporting member. When no liquid pressure extends from the upstream -17- (15) (15) 200404716 side, the thin-walled portion of the valve element is in contact with the outer periphery of the valve element support member to close the outlet hole. When the liquid pressure is applied to it from the upstream side, the thin-walled portion expands and deforms toward the outside (downstream side) of the outlet portion, thereby opening the outlet hole. When the outlet hole is opened, the upstream of the outlet element and the flow path between the outlet holes are established to communicate with each other, so that the liquid is transferred from the outlet hole. In the fifth transfer device, the transfer of liquid from the outlet hole can be achieved by applying a pressure to the container body, and the container system is connected to a transfer device similar to that described above. Such characteristics and operations are similar to the aforementioned characteristics and operations. When the valve element returns to its original shape after the transfer operation, the aseptic access of the air through the air filter can be achieved, and the negative pressure of the external air is accelerated. Recovery of a deformed valve element (thereby, the valve element can be caused to act like a check valve). In the fifth transfer device, since the swelling deformation of the valve element is achieved by a liquid pressure lower than the pressure required to pass the liquid through the air filter, no leakage of liquid in the vent hole occurs during the transfer operation . In the meantime, because the expansion deformation of the valve element is not caused by the external pressure according to this structure (therefore, the expansion deformation cannot be achieved by a pressure equal to the air pressure from the outside through the air filter), it will not occur The outside air enters through the outlet hole instead of the ventilation hole, and the corresponding leakage of the liquid through the outlet hole does not occur during the recovery period of the container body. As a result, the fifth conveying device according to the present invention 'the conveying operation and recovery of the container after the conveying operation can be smoothly achieved, while at a high level' prevent the backflow of the liquid which has been conveyed from the outlet hole and the microfluid brought from the liquid to the upstream- 18- (16) 200404716 Entry of organisms and dust. In the fifth conveying device of the present invention, the valve element supporting member preferably has a flange on the upstream side of its circular portion, so that when no liquid pressure extends thereon, the valve body of the valve element and The flange contacts to close the flow path, and when liquid pressure is applied thereto, it undergoes bending deformation to open the flow path between itself and the valve element supporting member.

In this example, when no liquid pressure extends from the upstream side to the upper side, the thin-walled portion of the valve element not only contacts the outer periphery of the valve element support portion to close the outlet hole, but also brings the valve body into contact with the valve element. Contact the flange to close the flow path. Therefore, the closure of the outlet hole is more certain. When the liquid pressure is applied from the upstream side, the valve element not only expands and deforms the thin-walled portion to the outside (downstream) of the outlet portion, but also compresses and deforms the valve body, thereby forming (opening) itself. The flow path to the flange of the valve element supporting member. When the outlet hole and the flow path are opened as described above, the flow path upstream of the valve element and the flow path between the outlet holes are established to communicate with each other, so that the liquid is transmitted from the outlet hole.

In the fifth transfer device and in its preferred embodiment, the recovery of the deformed valve element is accelerated by the negative pressure generated by the recovery of the container body after the liquid force is removed to complete the transfer operation. It has been deformed and sucked in the outside air by the conveying operation, as described above. In the fifth transfer device of the present invention, the valve body of the valve element is preferably integrally formed on the inner surface of the outlet portion, which makes the process of manufacturing the transfer device more efficient. Methods for integrally forming the valve element and the outlet include, but are not limited to, multi-color molding and insert molding. -19- (17) (17) 200404716 [Antibacterial treatment] In the transfer device of the present invention, the valve element and / or the outlet hole are preferably subjected to an antibacterial treatment. When the valve element and / or the outlet hole are subjected to an antibacterial treatment, the effect of preventing the breeding of bacteria can be achieved after the transfer operation is completed for the liquid left near the outlet hole. The components subjected to the antibacterial treatment can be selected according to the configuration of the transfer device. The antibacterial treatment can be applied to various members such as, but not limited to, the entire outlet portion, valve seat, container body, the surface of the cover covering the outlet portion (especially the inner surface contacting the outlet portion), provided on the inside of the cover. Water-absorbing material (sponge, cloth, paper, hydrogel, etc.). The antibacterial treatment can be performed by mixing chemicals such as disinfectants or antibacterial agents into elastic materials such as thermoplastic elastomers (made of valve elements), or resin materials made of outlets, outlet holes, and valve seats. Or in raw materials made of water-absorbent materials or the like, or by coating the surface of a valve element, an outlet portion or the like where a chemical has been formed, or by applying a surface treatment such as a silane coupling or a selenium coating Used to form a valve element, an outlet, a material of a cover, or a water-absorbent material in a cover. The antibacterial treatment can be applied to a hydrosol containing acrylamide polymer and a water-swellable clay mineral by coating the surface with selenium. [Liquid Filter] The transfer device of the present invention preferably has a liquid filter disposed upstream of the outlet hole 'or upstream of the position where the flow path is opened / closed by the valve element. By providing a liquid filter, it is possible to reliably prevent or restrict the residual liquid -20- (18) (18) 200404716 from entering (returning) the body of the container connected to the transfer device, if it is left near the outlet hole of the outlet Residual liquid is contaminated by microorganisms or dust. That is, it is better to configure a liquid filter to prevent or restrict the entry of contaminants into the container connected to the transfer device. A liquid filter having a fine mesh of about 0.2 to 0.45 // m makes it difficult to apply the transfer device of the present invention to a container containing a suspension. On the other hand, this makes it possible to reliably prevent or restrict the residual liquid from entering (backflowing) into the container body connected to the conveying device of the present invention, and if the residual liquid contaminated by microorganisms or dust flows back through the outlet hole. A liquid filter with a coarse mesh of 10 to 20 // m makes it possible to also apply the transfer device of the invention to a container containing a suspension. In this example, it is not necessary to consider the loading of the liquid filter through the suspension, and this effect can be achieved because the solvent in the container is prevented from evaporating, and, as a result, the suspended components can be prevented from condensing Near the exit hole. Also because even a liquid filter with such a coarse mesh can inhibit the passage of microorganisms to a certain degree, it is possible to restrict the residual liquid from entering the container body to a certain extent. If the residual liquid contaminated by microorganisms or dust passes through the outlet hole, Enter (reflow). [Container] The container of the present invention for achieving the aforementioned object has a mouth of the container body in which the transfer device of the present invention is mounted. The container of the present invention is suitable for use as an eye dropper for containing an ophthalmic solution. -21-(19) (19) 200404716 [Embodiment] With reference to the accompanying drawings', the transfer device of the present invention and a container provided with the transfer device will now be described. [First Conveying Device and Container] The first conveying device 10 according to the present invention includes: an outlet portion 11 having a substantially bottomed tube (or substantially bowl shape) having an outlet hole 12 at the bottom thereof; a valve element 13, It is arranged at the outlet portion 11 and closes the outlet hole i 2 when no liquid pressure is exerted on it from the upstream side U. When the liquid pressure is pushed from the upstream side U, it performs compression deformation and opens the outlet hole 1 2 The locking member 14 is disposed at the outlet portion 11 to define the flow path 15 between itself and the inner surface lid of the outlet portion, and its fixed valve element 13 is on the upstream side U; and, the ventilation hole 16 is via The air filter 17 communicates with a flow path provided upstream of the valve element 13. The outlet hole 12 is normally closed by the valve element 13. However, when the liquid pressure is applied to the valve element i 3 from the upstream side U through the flow path 15, the valve element 13 is compressed and deformed so that A gap is formed between the outlet hole 12 of the outlet portion 1 j and the valve element 13. This enables the liquid contained in the container to be conveyed through this gap. The valve element 13 is fixed by the locking member 4 in the conveying device 10, and the space between the locking member 14 and the inner surface 1 1 d of the outlet portion is a liquid flow path 15. The exit section 11 includes two members: an exit section body 11a having an exit hole 12, and a link section lib, which is disposed upstream of the exit section body 11a, and is connected to the side U- (20) (20) 200404716 U The mouth of the container needs an air filter 17 installed in the ventilation hole 16. The exit portion body 11a and the link portion 11fc are integrated with the air cleaner i 7 incorporated in the joint 1 1 c using a joining mechanism such as ultrasonic welding. The first transfer device 10 is, for example, attached to the mouth of the container body 21, as shown in FIG. In the example of the container 20 shown in FIG. 2, the conveying device is attached to the neck 22 of the container 20 via a plug 23. The plug 23 is slidably inserted into the neck 22 of the container 20, as shown in Figs. Fig. 2 is a sectional view of the container 20 in a used state, and Fig. 3 is a sectional view of the container 20 before being sealed. In the unsealed state shown in FIG. 3, not only the cover 26 is attached to the outlet portion 11, but also the stopper 27 is inserted between the conveying device 10 and the container body 21. Therefore, the conveying device 10 is slightly inserted into the container body 21. In this state, the tip 23 a of the plug 23 is in contact with the flange 19, and the flange 19 is disposed on the inner surface of the conveying device 10. As a result, the conveying device 10 is blocked by the flange 19 and the tip 23a of the plug 23, whereby the liquid in the container body 21 can be kept at a high level of sterility, and the deterioration of the liquid in the container can be prevented. (Oxidation). The sequence of the transfer operation of the first transfer device of the present invention and a container provided with the same is shown in Figs. Fig. 4 (a) shows a state in which pressure is not applied to the container body 21, and the valve element 13 of the transfer device closes the outlet hole 12. As a result, the liquid 24 contained in the container body 21 remains in the container body 21 and the conveying device without being conveyed by the outlet portion 11. Fig. 4 '(b) shows the state of the container body 21 under pressure. In this state, 'Transfer-23- (21) (21) 200404716 The valve element 1 3 of the delivery device is under the pressure of the liquid 24 contained from the upstream side, and therefore the compression deformation of the valve element 13 is performed to open The outlet hole 12 thereby conveys the contained liquid 24 in the form of drops 25. Fig. 5 (a) shows a state following the state shown in Fig. 4 (b). In this state, the pressure on the container body 21 is removed. In this state, since the valve element 13 of the conveying device does not receive the pressure of the liquid 24, the valve element 13 returns to the original shape in the non-pressure state, thereby closing the outlet hole 12 again. Fig. 5 (b) shows a state following the state of Fig. 5 (a). In this state, the valve element 13 returns to its original shape in the pressureless state because the pressure on the container body 21 is removed. In this state, because the valve element 13 of the conveying device closes the outlet hole 12, the outside air enters the container body 21 only through the ventilation hole 16. In another embodiment of the first transfer device 10 'and the container 20' provided with the device, as shown in Fig. 6, a liquid filter 18 is provided on a flow path 15 communicating with the outlet hole 12. As a result, if the residual liquid contaminated by microorganisms or dust flows back from the outlet hole 12 as described previously, it is possible to prevent or restrict this residual liquid from entering the container body 21 connected to the conveying device 10 '. The first transfer device of the present invention can also cause, for example, the valve elements 1 3 a and 13 b to have the cross-sectional structure shown in FIGS. 7 and 8. That is, the exposed end of the valve element 13 through the outlet hole 12 may be a flat conveying device 10a as shown in FIG. 7, or the valve element i3b may have a recess 13c at its tip as shown in FIG. 8. . When the liquid pressure is applied from the upstream side U, it is more likely than a valve element (3, 13a shown in FIGS. 1 and 7) having no recessed portion 1 3c. Press

& 3S -24- (22) (22) 200404716 shrinkage (and it is more likely to open the exit hole 1 2). Further, the valve element 1 3 b is less prone to such a problem, in which the outlet hole 12 is inadvertently opened by the pressure from the outside of the outlet portion 1 1, and thus the transfer operation is more smoothly and the backflow is prevented more favorably. [Second Conveying Device and Container] The second conveying device 30 according to the present invention includes, for example, an outlet portion 31 having a substantially bottomed tube shape with an outlet hole 32 at the bottom thereof; and a ring-shaped valve element 33 disposed at the outlet portion 31. The valve seat 34 is installed from the open end 3 1 d side of the outlet portion 31 and contacts the valve element 3 3 on the upstream side U when the outlet hole 32 is defined as the downstream side D, and the ventilation hole 36. It communicates with the flow path 35 provided at the position U on the upstream side of the valve element 33 via the air filter 37, as shown in FIG. 9 (sectional view) and FIG. 10 (exploded sectional view). The outlet portion 31 includes two members: an outlet portion body 31a having an outlet hole 32, and a link portion 31b, which is disposed on the upstream side U of the outlet portion body 3a and is connected to the mouth of the container because An air filter 37 needs to be installed in the ventilation hole 36. The outlet portion body 31a and the link portion 31b are integrated with an air filter 37 inserted through a flange 3 1 f (a joint 3 1 c) using a joining mechanism such as ultrasonic welding. In the transfer device 30 shown in FIGS. 9 and 10, the entire combination of the outlet portion 31a and the valve element 33 is formed by combining at least a part of the annular valve element 33 and the inner surface 31e of the outlet portion 31a. , As shown in the plan view of Π. The part marked with a dashed line in Figure 11 (a) is a ventilation hole. The air hole is covered with an air filter 3 7 through 25- (23) (23) 200404716. Fig. H (b) is a bottom view of the entire combination of the outlet body 31a and the valve element 33 ', wherein the outlet body 31 & has a through hole 31g (injection hole) passing through the bottom thereof. The exit body 3 1 a can be formed, for example, by injecting a resin into a mold. The outlet portion body 31a and the valve element 33 can be used to replace (or move) the mold (movable mold) on the open end 31d of the outlet portion 31 after the injection described above (refer to FIG. 10), and then pass through the outlet portion. When the injection element 3 of the JS part of the body 3 1 a is injected with a thermoplastic elastomer and integrated, when the valve element 33 is integrally molded, material is injected through the open end 31d of the outlet part, and the hole is injected. 31g becomes unnecessary. The transfer device 30 and the valve seat 34 shown in Figs. 9 and 10 are attached to the outlet 31a from the upstream side U having a tubular body 34c. The tubular body 34c has a flange 34d and a valve seat 34a. The openings on the opposite sides of the flange 3 4d side of the round-trip tubular body 34 are arranged, as shown in the plan view (a) and the bottom view (b) of FIG. 12. The portion marked with the reference number 34b having the annular valve element 33 together defines a liquid flow path 35. The reference number 34e represents a joint between the tubular body 34c and the valve seat 34a. In the integrally molded body shown in Fig. 11 (a), the valve element 33 has a ring shape. However, the valve element is not limited to a structure formed in the circumferential direction X (ring) of the outlet portion body 31a, and may have such a structure as shown in FIG. 13 (a), for example. Assume that the valve element has the structure shown in FIG. 1 3 (a), a flow path (not shown), which is formed on the valve seat (not shown) and the outlet portion 31a by compression deformation of the valve element 33. It becomes narrower than in the case where the valve element 33 has a ring shape (FIG. 11). Therefore, its shape can be determined according to the width of the flow path required by the conveying device. Reference numeral 31e 'in FIG. 13 (a) represents the inner surface of the outlet portion body 31a, and 3 1Γ represents the flange of the outlet portion body 31a. Fig. 13 (b) shows a valve seat portion 34 'of a transfer device having a valve element 33' having a shape shown in Fig. 13 (a). The flow path 35 of the valve seat portion 34, can be provided in accordance with the shape of the valve element 33 'of the transfer device shown in Fig. 13 (a). Reference numeral 34a 'in Fig. 13 (b) represents a valve seat. The second transfer device 30 is used when attached to the mouth of the container body 41, as shown in FIG. The sequence of the transfer operation of the second transfer device of the present invention and the container provided with the device is shown in Figs. 15 and 16. Fig. 15 (a) shows a state in which pressure is not applied to the container body 41, and the valve element 3 3 is closed to the flow path 3 5 on the outlet body 3 1 a and the flow path 3 5 on the joint 3 1 b side. Therefore, the passage between the outlet hole 32 and the container body 41 is closed. As a result, the liquid 44 contained in the container body 41 remains in the container body 41 and the conveyance device 30 without being conveyed through the outlet portion 31. Fig. 15 (b) shows the state of the container body 41 under pressure. In this state, the valve element 3 3 is under the pressure of the liquid from the upstream side U through the flow path 3 5 and is thus compressed and deformed. As a result, a gap is generated between the valve element 33 and the valve seat 34a (in other words, the valve element is released), so that the flow path 3 5 on the outlet 3 1 a side and the flow path 3 5 on the joint 3 1 b side Circulate each other. Therefore, the liquid 44 contained in the container body 41 is transferred from the outlet portion 31 in the form of drops 45. Fig. 16 (a) shows a state following the state shown in Fig. 15 (b), in which the pressure is removed when the container body 41 is on. In this state, because the valve element 3 3 of the transmission 1 • 27- (25) (25) 200404716 device does not receive the pressure of the liquid 4 3, the valve element 3 3 returns to its original shape in a pressureless state, thereby closing the The gap between the valve element 3 3 and the valve seat 3 4 a. FIG. 16 (b) shows a state following the state of FIG. 16 (a), in which the container body 41 is restored to its original shape in a pressureless state because the pressure on the container body 41 is removed. In this state, because the valve element 3 3 of the conveying device closes the flow path 35, the outside air enters the container body 41 only through the vent hole 3 6. As shown in Figs. 14 and 17, the plug 43 is slidably inserted into the neck portion 42 of the container 40. As shown in Figs. FIG. 14 shows a cross section of the container 40 in use, and FIG. 17 shows a cross section of the container 40 before it is not sealed. In the state before being sealed as shown in Fig. 17, the transfer device 30 is slightly inserted into the container body 41. In this state, the distal end 43 a of the plug 43 is in contact with the flange 39, and the flange 39 is disposed on the inner surface of the outlet portion 31. As a result, the flow path 35 of the conveying device 30 is blocked by the flange 39 and the end 43 a of the plug 43, whereby the liquid in the container body 41 can be kept at a high level of sterility, and the liquid in the container can be prevented. Protected against degradation (oxidation) in the process. The conveying device 30 shown in FIG. 17 has a bolt portion 31h to which the cover 46 fastens the outlet portion 31a. However, the sponge 47 is disposed on the inner surface of the cover 46 at a position contacting the outlet hole 32 of the outlet portion 31. Since the sponge 47 absorbs the residual liquid 3 5 'remaining in the outlet hole 32 after the completion of the transfer operation (refer to Fig. 16 (b)), the residual liquid can be prevented from being supplied to the next transfer operation. Reference numeral 46a denotes a thread formed on the inner surface of the cover 46. -28- (26) 200404716 In the conveying device 30 shown in Fig. 17, the open end 46b of the cover blocks the ventilation hole 36 of the conveying device 30. As a result, when a liquid-containing solution (water) or the like in the container body 41 is gradually steamed through the air filter 37, such a problem is prevented from occurring, resulting in a change in the pH of the contained liquid. Second transmission The device is not limited to the device described above, and may have such a structure as shown in FIG. 18, for example. Similar to the transfer device 30 shown in FIG. 9, the transfer device 30 'shown in FIG. 18 includes: an outlet portion 31 having a substantially bottom tube shape with an orifice 32 at its bottom; an annular valve element 33', The valve seat portion 34 is disposed at the outlet portion 31, and is installed from the open end side of the outlet portion 31. When the outlet hole is defined as the downstream side D, the valve element 3 3 on the upstream side U contacts the ventilation hole 3 6. It communicates with the flow path 35 through the air filter 37, and the liquid filter 38 is disposed on the upstream side U of the valve seat portion 34 and covers the path 35. The conveying device 30 is the same as the conveying device shown in FIG. 9 except that the shape of the valve element 3 3 and the outlet 3 1 which accommodates the former close to the outlet hole 32 are different, and the liquid filter 38 is provided in the flow path. 3 5 and beyond. [Third Conveying Device and Container] The third conveying device 50 according to the present invention includes: an outlet portion 51 having a substantially bottomed tube shape with an outlet hole 52 at the bottom thereof; and a valve element 53 made of an elastic material and arranged in The outlet portion 5 1 (the flow path 5 5 communicating with the outlet hole 52) closes the outlet hole 5 2 when no liquid pressure is applied from the upstream side U, and pushes the body into fluid when the liquid pressure flows from the upstream side u. For example, when 3 2 flow removal parts are installed with the same pressure -29-»43 (27) (27) 200404716, they are expanded and deformed and the outlet hole 52 is opened; and the ventilation hole 56 is connected with the flow path 5 5. The flow path 5 5 is provided at a position U on the upstream side of the valve element 53 via an air filter 57. The outlet portion 51 includes two components: an outlet portion body 51a having an outlet hole 52, and a 'link portion 51b, which is disposed on the upstream side U of the outlet portion body 51a and is connected to the mouth of the container because an air filter needs to be installed 57 in ventilation hole 56. The exit portion body 51a and the link portion 51b are integrated with the air filter 57 fitted into the flange 51f (the joint 51c) using a joining mechanism such as ultrasonic welding. FIG. 2 is a plan view of the 1-series outlet body 5 1 a (viewed from the upstream U). As shown in the figure, a ridge portion (valve seat) 52b for engaging with the convex portion of the valve body 53a is provided on the bottom of the substantially tubular outlet portion body 51a. Ventilation holes 56 are provided at predetermined intervals in the flange 51f (joint 51c) for mounting the connecting rod portion 51b paired with the outlet portion 51a, and an air filter 57 is installed in the ventilation hole 56 in order to reach the air Enter aseptically. FIG. 22 shows the valve element 53 and the valve element supporting member 54 of the lock valve element, FIG. (A) shows its plan view (viewed from the upstream side U), and FIG. (B) shows its bottom view (viewed from the downstream side D) . As shown in this figure, the valve element supporting member 54 used to place the valve element 53 in the outlet portion 5 1 a has: a pipe member 54 a; a locking member 54 b, which is arranged on the bottom of the former and locks the valve element 53; and The flange 54c is arranged at the open end on the opposite side and engages the outlet portion body 51a. As shown in Figs. 19 to 22, the valve element 53 is locked to the valve element supporting member 54 and is then fitted into the inner surface 51e of the outlet portion body 51a. -30- (28) (28) 200404716 Assuming that the valve element 5 3 is made of an elastic material with thermoplastic properties (such as a thermoplastic elastomer), the valve element 53 and the valve element supporting member 54 can be formed by a multi-color mold. It is integrally formed by molding or insert molding. This completes the manufacture of these two components in a simple manner. In the case where the valve element 53 is made of a non-thermoplastic elastic material, and a molding technique such as injection molding cannot be used, the valve element 53 and the valve element supporting member 54 may be, for example, by attaching the valve element supporting member 5 4 is inserted into an injection mold, and then a material is injected to mold the valve element 53 to be integrally formed. In the embodiment shown in FIG. 19, the valve element 5 3 includes: a valve body 5 3 a as a valve shaft; a convex portion 53 b disposed at a tip of the valve element body 53 a as a valve head; and a flange 53 c For engaging the valve body 53a and the valve element supporting member, an example is shown in FIG. 23, and the elastic member shown in FIGS. 19 and 20 can be inserted into the outlet portion body 51a by inserting the valve element supporting member 54 having the valve element 53 Obtained from the open end (refer to 51d of FIG. 20) to place the convex portion 53b of the valve body 53a on the ridge portion 52b formed on the inner wall 5 2a of the flow path of the outlet hole 52, and then apply strong pressure from the liquid or from The air on the upstream side U slides the convex portion 5 3 b of the valve body toward the outlet hole 52 with the convex portion 53 b of the valve body. The first transfer device 50 is used when attached to the mouth of the container body 61, for example, as shown in FIG. The container 60 shown in FIG. 24 has a neck portion 62 in which a plug 63 is fitted into the container body 61. The sequence of the transfer operation of the second transfer device of the present invention and the container provided with the device is shown in Figs. Figure 25 (a) shows no application

-31-(29) (29) 200404716 Pressure state to the container body 61. In this state, the valve element 5 3 blocks the passage between the flow path 5 5 on the side of the outlet hole 5 2 and the flow path 5 5 on the upstream side of the valve element 5 3, so the outlet hole 5 2 and the container body 6 1 are closed. Pathway. As a result, the liquid 64 contained in the container body 61 remains in the container body 61 and the transfer device 50 without being transferred by the outlet portion 51. Fig. 25 (b) shows the state of the container body 61 under pressure. In this state, the valve element 53 is under the pressure of the liquid from the upstream side U through the flow path 55, and therefore undergoes an expansion deformation toward the outlet hole 52. As a result, the convex portion 5 3 b of the valve body 5 3 a and the ridge portion 52 b formed on the inner wall 52 a of the outlet hole 52 communicate with each other, so that the liquid 64 contained in the container body 61 is transferred from the outlet in the form of drops 65.部 51。 51. FIG. 26 (a) shows a state following the state shown in FIG. 25 (b), in which the pressure on the container body 61 is removed. In this state, since the valve element 53 of the conveying device does not receive the pressure of the liquid 64 contained therein, the valve element 5 3 returns to its original shape in a non-pressure state, thereby closing the gap between the valve element 53 and the ridge portion 52b. . Fig. 26 (b) shows the state following the state of Fig. 26 (a), in which the container body 61 is restored to its original shape in the pressure-free state because the pressure on the container body 61 is removed. In this state, since the valve element 53 of the conveying device closes the position of the flow path 55 at the ridge portion 52b of the outlet portion, the outside air enters the container body 61 only through the ventilation hole 56. As shown in Figs. 24 and 27, the plug 63 is slidably inserted into the neck portion 62 of the container 60. As shown in Figs. The function of the plug 23 is similar to that of the container 40 provided with the second transfer device 30. Fig. 24 shows a cross section of the container 60 in use, and Fig. 27 shows a cross section of the container 60 before being sealed. In Fig. -32- 59 (30) 200404716 27, the reference number 63a shows the end of the plug 63, and the reference number shows the flange provided on the inner surface of the exit portion 51. The conveyance device 50 shown in FIG. 27 has a cover 5 1 h on which the cover 66 fastens the outlet portion 5 1 a. However, the sponge 6 7 is disposed on the inner surface of the cover 66 at the outlet hole 52 of the outlet portion 51. Location of contact. The opening 6 6b of the cover blocks the ventilation hole 56. The sponge 67 and the open end 66b show similar functions as the container 40 provided with the two transfer devices 30. Reference numeral 66a designates a thread formed on the inner surface of the cover 66. [Fourth conveying device and container] For example, as shown in FIG. 28, the fourth conveying device according to the present invention includes: an outlet portion 71 having a substantially bottomed tube having an outlet 72 at its bottom; a valve element 73 to Made of an elastic material, when no hydraulic pressure is applied to it from the upstream side U, the outlet hole 72 is closed from the outside of the outlet portion 71, and when the liquid pressure from the liquid pressure 'from the upstream side U comes into contact with the valve seat 74, Expansion deformation is performed to open the outlet hole 72; and the vent hole 76 communicates with the flow path, which is positioned upstream of the valve element 73 via the air filter 77. The outlet portion 71 includes two members: an outlet portion body 71a having a □ hole 72, and a link portion 71b, which is disposed on the upper side U of the outlet portion body 71a and connected to the mouth of the container because an air filter 77 needs to be installed Vent hole 76. The outlet portion 71a and the link portion 71b are integrated with an air filter 7 7 fitted with a flange 7 1 f (joint 7 1 c) using a joining mechanism such as sonic welding. / Body surface No. 70 The hole body is set to swim in the super air when it is closed -33- (31) 200404716 Figure 29 (a) is a bottom view of the exit body 7 1 a (viewed from the downstream side D), and Figure 29 ( b) is a sectional view taken along line AA of FIG. 28. The mouth body 71a has several ventilation holes 76 and an air filter 77. The air filter 77 fills the holes in the flange 7 1 f (joint 7 1 c) similarly to the 'flange 71f (joint 71c) system shown in the figure. It is used to mount the link portion 71b, and the lever portion 71b is paired with the outlet portion body 71a. The functions of the air filter 77 and the ventilation 76 are similar to those of the container 60 provided with the third transfer device 50. As shown in FIGS. 28 to 29, the valve element 7 3 is disposed in contact with the following two surfaces. The outer surface of the bottom of the outlet portion has a substantially bottom tube and a substantially bowl shape, and has an outlet hole at its bottom, and The bottom surface (outer surface) of the valve seat 74 defines a portion of the flow path 75 in the outlet portion body 71a and closes the outlet portion. The valve element 73 is preferably formed integrally with the outlet portion body 71a on the outer surface of the outlet body 71a made of resin with a thermoplastic material. The integral formation makes the manufacturing process of the conveying device 70 simpler. The fourth conveying device 70 is used when attached to the mouth of the container body 81, for example, as shown in FIG. 30 (a). The container shown in FIG. 30 (a) has an inner plug 83 provided in a neck portion 82 of the container body 81. The function of the plug 83 is similar to that of the container 40 provided with the second transfer device 30, or the function of the container 60 provided with the second transfer device 50. The transfer operation sequence of the transfer device of the present invention and a container provided with the device is shown in Figs. 30 and 31. Fig. 30 (a) shows a state where the pressure is not applied to the trough body 81. In this state, the valve element 7 3 closes the outlet and observes the 21-hole example or the bottom spring part. The simple hole 80 attached to the hole-34- Η · 4ο (32) 200404716 72 flow path 75, so The passage between the outside of the outlet hole 72 and the container body is closed. As a result, the liquid 84 contained in the container body 81 remains in the container 81 and the transfer device 70 without being transferred by the outlet portion 71. FIG. 30) shows a state where the container body 81 is under pressure. In this state, the valve element 73 is expanded and deformed toward the outlet hole 72 under the pressure of the liquid applied from the upstream side U through the flow path 75. As a result, a first-stage circuit is formed between the valve element 73 and the valve seat portion 74, so that the liquid 84 contained in the container body 81 is transferred from the outlet 71 in the form of drops 85. Fig. 31 (a) shows a state following the state shown in Fig. 30 (b) in which the pressure on the container body 81 is removed. In this state, since the valve element 73 of the transmission device does not receive the pressure of the liquid 84, the valve element 73 returns to its original shape without pressure, thereby closing the gap between the valve element 73 and the seat 74. FIG. 31 (b) shows the state following FIG. 31 (a), in which the container body 81 is restored to the original shape in a non-pressure state, and the pressure on the container body 81 is removed. In this state, because the conveying valve element 73 closes the flow path 75 between the valve element 73 and the valve seat 74 of the outlet 71a, the outside air enters the trough 8 through the ventilation hole 76 only, as shown in FIG. 32 The transmission device 70 is another embodiment of the fourth transmission device. For example, the valve element is made of an elastic material having thermoplastic properties. The valve element 73 and the outlet portion 71a may be integrally formed, similar to the transfer device 70 shown in FIG. The valve element 73 may be formed of an elastic material other than thermoplastic elasticity, such as a non-thermoplastic rubber, as long as 8 1 body (b lower body fruit part 0, the body of the valve for the recovery body is here -35- (33) 200404716 The material is easy to bend, and it is easy to bend and deform by liquid pressure. The valve is an example made of an elastic material that is not thermoplastic, and therefore, molding techniques such as injection molding cannot be used, and the valve element 7 3 Can be inserted between the outlet portion body 71a, the valve seat 74 (and the tubular body 74a), and is arranged at the outlet portion 71. The conveying device 70 'shown in FIG. 32 is similar to that shown in FIG. 28. The conveying device 70 is different from the outlet 71a and the valve element 73. [Fifth conveying device and container]

As shown in FIG. 33, for example, the fifth transfer device 90 according to the present invention includes: a tubular outlet portion 91 having a substantially bottomed tube (or substantially bowl-shaped) having a hole 91d at its bottom; a valve element 93, It has a solid ring-shaped valve body 93b and a substantially ring-shaped thin-walled portion 93a. The latter is the same as the former, and is formed by fixing the valve body 93b in the outlet portion 91. The thin-walled portion 9 3 a The through-hole 9 1 d is exposed to the outside of the outlet portion 91; the cylindrical valve element supporting member 94a is arranged at the outlet portion 9 1 and defines the countersunk hole 92 and the valve element 93; and, the ventilation hole 96, and The flow path 95 communicates with each other. The flow path 95 is provided at a position U on the upstream side of the valve element 93 via an air filter 97. The outlet hole 92 is normally closed by the thin-walled portion 93a of the valve element 93. However, when the liquid pressure is applied to the valve element 93 from the upstream side through the flow path 95, the thin-walled portion 93a expands and deforms to generate a gap Between the thin-walled portion 93a and the valve element supporting member 94a, -36- (34) (34) 200404716 transfers the liquid in the container through this gap. In the embodiment shown in Fig. 33, the valve element 93 is fixed to the inner surface of the outlet portion 91a, and the thin-walled portion 93a exposes the hole 91d (the outlet portion body 91a) passing through the outlet portion 91. In Fig. 33, reference numeral 94c denotes a tubular member, and the tubular member 94c holds the valve element supporting member 94a and the flange 94b in the outlet portion 91 (the outlet portion body 91a). The valve body 93b has a sufficient thickness to be integrally formed on the inner surface of the outlet portion body 91a. The outlet portion 91 includes two members: an outlet portion body 91a having an outlet hole 92, and a link portion 91b, which is disposed on the upstream side U of the outlet portion body 91a and connected to the mouth of the container because air needs to be installed The filter 97 is in the ventilation hole 96. The outlet portion 91a and the link portion 91b are integrated with an air filter 9 7 fitted into the joint 9 1 c using a joining mechanism such as ultrasonic welding. The transfer device 90 of the present invention is provided with the same sequence of transfer operations as the container 100 shown in Figs. 36 and 37. Fig. 36 (a) shows a state where pressure is not applied to the container body 101. In this state, the valve element 93 of the transfer device closes the outlet hole 92. As a result, the liquid 104 contained in the container body 101 remains in the container body 101 and the transfer device without being transferred by the outlet portion 91. Fig. 36 (b) shows the state of the container body ι01 under the pressure applied to it. In this state, the valve element 93 is under the pressure of the contained liquid 104 from the upstream side U, and therefore the expansion deformation of the valve element 93 is performed, so that the outlet hole 92 is opened and the contained liquid 104 is dripped 1 〇5。 And the form of transmission. Fig. 3 is an enlarged view of p part 9 1 in the state shown in Fig. 3 6 (b). 0 -37- (35) (35) 200404716 Fig. 3 7 (a) The status shown. The pressure on the container body 101 is removed. In this state, since the valve element 93 of the conveying device does not receive the pressure of the liquid 104, the valve element 93 returns to its original shape in a pressureless state, thereby closing the outlet hole 92 again. Fig. 37 (b) shows the state following the state of Fig. 37 (a), in which the container body 101 is restored to its original shape in a pressureless state because the pressure on the container body 101 is removed. In this state, because the valve element 93 of the transfer device closes the outlet hole 92, outside air enters the container body 101 only through the ventilation hole 96. In the container 100 shown in FIG. 34, the conveying device 90 is attached to the neck portion 102 of the container 100 via a plug 103. The plug 103 is slidably inserted into the neck portion 102 of the container 100. FIG. 34 is a cross-sectional view of the container 100 in use. The state in which the end 103a of the plug 103 and the flange 99 are engaged with each other (in other words, the seal is not broken), and the effect of joining the two members is similar to other implementations shown in FIGS. 3, 17 and 27. example. The transfer device 90 shown in Fig. 35 has a cover 106, and an outer surface of the bolt inlet / outlet body 91a. The cover 106 has a recessed portion 108 formed at a position corresponding to the outlet hole 92 so as to be plugged into the outlet portion body 91a. The surface of the cover 106 and the outlet hole 92 are in contact with each other at the recess 108. The sponge 1 07 is arranged around the recessed portion 108 so that the residual liquid 105 remaining in the outlet hole 92 (refer to FIG. 37 (b)) is squeezed out by the inner surface of the lid positioned at the recessed portion 108, and is squeezed by the sponge 1 07 and absorbed. In the transfer device 90 shown in FIG. 3 (a), the open end 106b of the cover blocks the ventilation hole 96 of the transfer device 90. As a result, this kind of problem is prevented from happening -38- (36) (36) 200404716, because the liquid solvent (water) or the like contained in the container body 101 gradually evaporates through the air filter 97, and this Changes in the pH of the contained liquid. In another embodiment of the fifth transfer device 90 ′ shown in FIG. 39, the closing of the flow path 95 is not only caused by the contact between the thin wall portion 93 a and the valve element supporting member 94 a, but also by the valve element supporting member 94 a and The contact of the flange 94b is achieved. As a result, the flow path 95 can be reliably achieved by closing the valve element 93 ', but at a high level, the backflow of the residual liquid containing microorganisms and dust that has been transmitted from the outlet hole 92 is prevented. Fig. 40 is an enlarged view of the exit portion 91 of the conveying device 90 'in the state shown in Fig. 38. In the fifth transfer device 90, 90 ', a liquid filter (not shown) may be provided upstream of the position where the flow path 95 is opened and closed (the contact position between the thin-walled portion 93a and the valve element support member 94a) Contact position between the valve body 93b 'and the flange 94b). The effect of the liquid filter is similar to the examples of the other embodiments shown in Figs. In a container 100 provided with a fifth transfer device, in the case where the container is used to contain an ophthalmic solution, for each transfer operation, a drop of about 20 to 40 / L (ml) of liquid is applied. The valve The outer diameter of the element supporting member 94a is set in the range of 0.6 to 2.0 legs, and preferably in the range of 1.0 to 1.2 mm. The thickness of the thin-walled portion 93a of the valve element 93 is set in a range of 0.8 to 2.5 mm, and preferably in a range of 0.8 to 1.5 mm. In order to prevent the liquid from leaking from the outlet hole 92, the thin-walled portion 93a of the valve element is preferably more or less inflated by the valve element supporting member 94a. Therefore, the -39- (37) (37) 200404716 of the thin wall portion 93a through which the support member 94a is inserted without the valve element is preferably slightly smaller than the outside diameter of the valve element support member 9a. For example, the inner diameter of the thin-walled portion 93a is preferably adjusted to a range of 50 to 99% of the outer diameter of the valve element supporting member 94a, and is preferably adjusted to a range of 60 to 80%. In such a conveying device 90 'as shown in FIG. 39, the closing of the flow path 95 is not only caused by the contact of the thin wall portion 93a and the valve element supporting member 94a, but also by the valve body 93b' and the flange 94b A greater effect of preventing the liquid from leaking out of the outlet hole 92 is achieved by contacting, so that the inner diameter of the thin-walled portion 9 3 a can be explained with fewer necessary conditions than the above example. In the following, the components of the conveying device and the container provided with the device according to the present invention will be described in detail. (Valve element) The valve element in the conveying device of the present invention must meet the following conditions, in which the compression or expansion deformation is easily achieved by applying a liquid pressure from the container body side, which is lower than the liquid passing through the air filter The required pressure and compression or expansion deformation cannot be achieved by the air pressure required for the air to pass through the air filter from the outside. Materials that can be used for valve elements include low hardness thermoplastic elastomers; gel-like materials; and glues such as natural rubber, silicone rubber, isoprene rubber, butyl rubber, butadiene rubber, and fluorinated rubber. Although there are no restrictions on the types of materials, in order to have the above-mentioned characteristics about expansion deformation or compression deformation, the hardness of the valve element is based on JIS A hardness (according to the specified JIS κ63 0 1 -5 · 2, spring hardness test〃 method) The measured spring hardness Hs (type A) is in the range of 0 to 40. Within the above range of 40- (38) (38) 200404716, the hardness of the valve element (JIS A) is preferably not higher than 30, more preferably within 20, and most preferably within 10. Although the lower limit of the hardness of the valve element (JIS A) is not further limited than the range including the above, depending on the material availability, the strength of the valve element and other factors, as far as JIS A is concerned, this range can be 2 or higher. Specific examples of the material of the valve element include the following. Examples of thermoplastic elastomers include modified SEBS copolymers such as SEBS, SBS, SIS, and modified maleic acid; styrene elastomers such as SEPS, SEB, and SEP; and hydroxyelasticity such as styrene-acrylic block copolymers Body; polyurethane elastomers; and mixtures thereof. Among the thermoplastic styrene elastomers, the "Septone" compound manufactured by KURARAY PLASTICS CO.? LTD is preferred. Examples of the colloidal material include a colloid containing a linear hydrocarbon polymer (hydroxy elastomer) (for example, “Cosmo-gel” manufactured by Cosmo Instrument Co., Ltd.); and a sand-urethane colloid (manufactured by "Chemitekgel (registered name)" manufactured by Chemitek Co.). The elastic material forming the valve element may be a foaming material (whose spaces are separated from each other so as not to penetrate into the liquid, or may be a material whose hardness is adjusted within the above range by using additives). In addition to hardness, the ability of a valve element to deform under liquid pressure can also be measured by the tensile strength and coefficient of the compressive elasticity of an elastic material. The elastic material forming the valve element preferably has a permanent strain ratio CS of not higher than 50 (measured at 70 ° C for 22 hours according to JIS K73 01), so that after repeated cycles of loading and unloading with this liquid pressure Does not break -41-(39) (39) 200404716 In the case where the delivery device is used outside the eyedropper, considering that the drop rate of ophthalmic solutions is usually about 0 · 0 5 m L / s, the valve The pressure required for the element to undergo compression or expansion deformation is preferably 0.01 to 0.2 Ma. When the valve elements 33, 33 'are fixed on the inner surface (31e) of the outlet portion 31 as shown in Figs. 9 and 18, the conveying devices 30, 30' are conveyed by the conveying devices 30, 30 ', and the outlet portion 31. a may be formed integrally from a thermoplastic material selected from the elastic materials listed above. In the case where the valve element is attached to the outlet portion 71a of the outlet portion 71a as an example of the transfer device 70 shown in FIG. 28, the valve element 73 and the outlet portion 71a may be integrally formed from a thermoplastic material selected from the elastic materials listed above. . The valve element is disposed at the outlet portion 71 'by being inserted between the outlet portion body 71a' and the tubular body 74a. The tubular body 74a is provided in combination with the valve element as an example of the transfer device 70 'shown in FIG. 32 The elastic material forming the valve element is not limited to a thermoplastic material. (Air Filter) The air filter used in the present invention must pass the liquid under a pressure higher than the pressure that compresses and expands the valve element of the conveying device, and the pressure required to pass air from the outside is low The pressure to open the outlet hole. Because the valve element of the conveying device is compressed and expanded to deform the pressure of the liquid contained in it, the speed of the conveying operation (droplet velocity of the conveyed liquid) changes. The liquid passing pressure and air passing pressure of the air filter must also be determined according to The application of the transmission device and the expected speed of the transmission operation are set. -42- (40) (40) 200404716 The drop rate of an ophthalmic solution is usually 0.05 mL / sec, which requires a pressure of 0.01 to 0.2 Mpa to compress or / expand the valve unit to deform, so the ophthalmic solution is dropped. Therefore, assuming that the transfer device is used in an eye dropper, when instilling an ophthalmic solution, the liquid passing pressure of the air filter of 0.01 Mpa or higher, preferably 0.2 Mpa or higher, makes it possible to prevent The ophthalmic solution leaked through the through hole. After instilling the ophthalmic solution, the rate at which air fills the compressed eyedropper (air entry speed) is usually 1 to 10 mL / sec. An air filter with an air passing pressure of less than 0.005 Mpa, preferably 0.001 Mp, can achieve the smooth entry of outside air through the through hole. The mesh size of the air filter is determined so that only air passes through, but blocks the liquid (liquid contained in the container of the present invention) transferred by the transfer device of the present invention, microorganisms such as bacteria, and floating by air Dust, and the mesh size is usually set in the range of 0.1 to 0.45 // m. Air filters that can be used in the present invention include, but are not limited to, hydrophobic P TF E membranes manufactured by GORE-TEX JAPAN IN C ·, and hydrophobic Durapore (PVDF) manufactured by Nihon Millipore Corporation. (Liquid filter) When the applied pressure is lower than a specific level, the liquid filter used in the present invention passes a liquid. When this liquid filter is installed upstream of the outlet hole, if the residual liquid left near the outlet hole returns to the upstream, -43- (41) 200404716 It is possible to prevent the residual liquid from entering the container connected to the transfer device . Liquid filters that can be used in the present invention include, but are not limited to, hydrophobic PTFE membranes manufactured by GORE-TEX JAPAN INC, and hydrophobic Durapore (PVDF) and hydrophobic PES manufactured by Nihon Millipore Corporation.

(Cover) In the conveying device of the present invention, in addition to the exit hole, an antibacterial treatment may be applied to the cover covering the outer surface of the exit portion. The portion of the cover to which the antibacterial treatment is applied is, but is not limited to, a portion whose inner surface is in contact with the outlet hole, and a sponge provided in the cover.

Since the backflow of liquid from the outlet hole to the upstream does not occur in the transfer device of the present invention, after the liquid transfer operation is completed, the residual liquid left behind is left near the outlet hole and does not return to the outlet portion. Therefore, by using a cover provided with a water-absorbent material, and after the liquid transfer operation is completed, the residual liquid remaining near the outlet hole is sucked with a sponge, and the supply of the residual liquid can be prevented during the next liquid transfer operation (refer to the figure 17 and Figure 27). When an antibacterial treatment is applied to the sponge in contact with the outlet hole, the antibacterial agent can be filtered from the sponge and accumulated on the outlet hole. To avoid this problem, this design can be used because the residual liquid extruded from the inner surface of the cover is also absorbed by the water-absorbing material provided around the inner surface of the cover (see Figure 3 5) The water-absorbing material includes, For example, sponges made of materials such as urethane or foamed -44- (42) (42) 200404716; cloths made of nonwoven, absorbent cotton or gauze; paper or hydrocolloids . The sponge can be made of urethane or foamed polyurethane materials which are well known in the art. The antibacterial treatment of the sponge is preferably coated on the surface of the sponge on which the antibacterial agent has been formed, or, when the sponge is formed, 'the antibacterial agent is mixed into the material of the foamed polyurethane or foamed polyurethane. . Further, a water-absorbing material having an antibacterial effect can be used. Antibacterial treatments applied to cloth, paper, and hydrocolloid temples include, for example, silane coupling and selenium coatings. Examples of the hydrocolloid include a mixture of an acrylamide polymer and a water-swellable clay mineral (see Japanese Laid-Open Patent Application No. 2002-5 3 629 and Japanese Laid-Open Patent Application No. 2002-53762). (Materials forming the conveying device, cover, and container body) The conveying device, cover, and container body may be made of a resin material such as PE or PP. In particular, PE and PP can be safely used in the application of medicines, and preferably, the container of the present invention containing a liquid medicine such as an ophthalmic solution is used. The resin material used to form the conveying device, the lid and the container body can be mixed with a disinfectant or an antibacterial agent in advance, which can enhance the effect of preventing residual liquid from remaining near the outlet hole after the liquid transfer operation is completed, and the effect of liquid degradation in the container. . Ammonium salts such as "Dimer 38" and "Dimer 13 6 /: J Grade 4" manufactured by Inui Corporation can be used as disinfectants. -45- (43) (43) 200404716 Agents, caps and containers The body can also be coated with a disinfectant after it is formed, or a surface treatment such as a silane coupling can be applied when forming the conveying device, the lid and the container body. A number of anti-bacterial materials can be used to form the exit portion, etc. Industrial Applicability The conveying device of the present invention can achieve the conveying operation and the smooth recovery of the container body after the conveying operation, and at the same time, prevent the backflow of the liquid that has been conveyed from the outlet hole, and the Microorganisms and ash enter the upstream. In the conveying device of the present invention, since the deformation of the valve element is achieved at a pressure lower than the passing pressure of the air filter, the conveyance through the outlet hole can be reliably achieved without being conveyed. Leakage of liquid occurred during operation. Furthermore, because the opening of the outlet hole and / or the flow path communicating with the outlet hole, the air from the outside was not used as an air filter. The over-pressure is achieved, and this problem does not occur when the outside air enters through the outlet hole instead of the through-hole during the recovery of the container body. Therefore, the conveying device of the present invention can achieve the conveying operation, as well as during the conveying operation. After that, the container body is smoothly restored, and at the same time, at a high level, the backflow of the liquid that has been transmitted from the outlet hole, and the microorganisms and dust in the liquid from entering the upstream are prevented. The conveying device of the present invention will not use the Japanese prior patent The porous filter disposed at the exit of the application No. 200 1 -206454 and the Japanese prior published patent application No. 2001-179017. Even Dangsuo, -46-(44) 200404716 The liquid contained is a suspension, and the outlet The probability of hole blocking is very low. Depending on the size and material of the valve element and the outlet hole, if the size of the suspension particles is about 50m / m or less, the outlet hole will not be blocked.

The container of the present invention causes the transfer device of the present invention to be mounted on its mouth. Therefore, at a high level, it is possible to prevent the backflow of the liquid that has been transmitted from the outlet hole, and the microorganisms and dust in the liquid from entering the upstream. Therefore, in order to prevent the degradation and deterioration of the liquid, it is possible to remove or reduce the use of disinfectant. Moreover, since the container of the present invention does not utilize a porous filter provided at its outlet hole, the outlet hole will not be blocked, and therefore, even when the liquid contained is a suspension, the smooth transfer of the liquid can be achieved, except that The liquid filter is placed outside the example upstream of the conveying device.

The conveying device of the present invention also preferably has a plug slidably held in the flow path or the container body of the conveying device so that the plug can contact the inner wall of the flow path of the conveying device, and when it is not used When the container is closed, the flow path is closed. This architecture ensures that the contained liquid remains in a sterilized state in an air-tight configuration until the container is used. And, because the liquid can be kept away from the valve element and the air filter before use, the stable quality can be maintained for a long time. The container of the present invention is suitable for use as an eye dropper containing an ophthalmic solution. [Brief Description of the Drawings] FIG. 1 is a sectional view showing an embodiment of a first conveying device. Fig. 2 is a sectional view showing an embodiment of a container provided with a first transfer device. -47- (45) (45) 200404716 Fig. 3 is a cross-sectional view showing a state before the container shown in Fig. 2 is not sealed. FIG. 4 is a cross-sectional view showing the container shown in FIG. 2 in use. FIG. 5 is a cross-sectional view showing a state following the state shown in FIG. 4. Fig. 6 is a sectional view showing another embodiment of a container provided with a first transfer device. FIG. 7 is a cross-sectional view showing another embodiment of the first transfer device. FIG. 8 is a cross-sectional view showing another embodiment of the first transfer device. Fig. 9 is a cross-sectional view showing an embodiment of the second transfer device. FIG. 10 is an exploded cross-sectional view showing the transfer device 30 shown in FIG. 9. Fig. 11 (a) is a plan view showing an example in which the outlet body 31 & and the valve element 33 are integrally formed, and Fig. 11 (b) is a bottom view thereof. Fig. 12 (a) is a plan view of the valve seat portion 34, and Fig. 12 (b) is a bottom view thereof. Fig. 13 (a) is a plan view showing another example in which the outlet body and the valve element are integrally formed, and Fig. 13 (b) is a plan view showing another example of the valve seat portion. Fig. 14 is a sectional view showing an embodiment of a container provided with a second transfer device. Figure 15 is a cross-sectional view showing the container in Figure 14 in use. FIG. 16 is a cross-sectional view showing a state subsequent to FIG. 15. Fig. 17 is a sectional view showing the container 40 shown in Fig. 14 in an unsealed state. Fig. 18 is a sectional view showing another embodiment of the second conveying device. -48- (46) (46) 200404716 Fig. 19 is a cross-sectional view showing an embodiment of the third conveying device. FIG. 20 is an exploded cross-sectional view of the transfer device 50 shown in FIG. 19. FIG. 21 is a plan view of the exit portion body 51 a shown in FIG. 20. Fig. 22 (a) is a plan view of the valve element supporting member 54 shown in Fig. 20, and Fig. 22 (b) is a bottom view thereof. Fig. 23 is a schematic diagram showing a procedure for assembling the transfer device 50 shown in Fig. 19. Fig. 24 is a sectional view showing an example of a container provided with the transfer device 50 shown in Fig. 19. Fig. 25 is a sectional view showing the state of the container 60 shown in Fig. 24 in use. Fig. 26 is a sectional view showing a state following the state shown in Fig. 25. Fig. 27 is a sectional view showing the container 60 shown in Fig. 24 in an unsealed state. Fig. 28 is a cross-sectional view showing an embodiment of a fourth conveying device. FIG. 29 (a) is a bottom view of the conveying device 70 shown in FIG. 28, and FIG. 29 (b) is a cross-sectional view taken along line A-A. FIG. 30 (a) is a cross-sectional view showing an example of a container provided with a fourth conveying device 70, and FIG. 30 (b) is a cross-sectional view showing a state in which it is used. A cross-sectional view of the state shown by). Fig. 32 is a sectional view showing another embodiment of the fourth transfer device. Fig. 33 is a cross-sectional view showing an embodiment of the fifth transfer device. -49- (47) (47) 200404716 Fig. 34 is a sectional view showing an embodiment of a container provided with a fifth conveying device. Fig. 35 (a) is a cross-sectional view showing the lid-equipped container 100 shown in Fig. 34, and Fig. 35 (b) is a cross-sectional view of the lid. Fig. 36 is a cross-sectional view showing the container of Fig. 34 in use. Fig. 37 is a sectional view showing a state following the state shown in Fig. 36. Fig. 38 is an enlarged sectional view showing an outlet portion of the container 100 shown in Fig. 36 (b). Fig. 39 is a sectional view showing another embodiment of the fifth transfer device. Fig. 40 is an enlarged sectional view showing an outlet portion of the container 100 'shown in Fig. 39 in use. Fig. 41 (a) is a front view showing an example of an eye drop device of the conventional technique, and Fig. 41 (b) is an enlarged cross-sectional view of its conveying device. FIG. 42 is a schematic diagram showing a problem with a conventional eye dropper. Comparison table of main components 10, 10 ', 10a, 10b, 30530, 50, 70, 70, 90590, Conveyor n, 3l, 51, 71, 71 ,, 91 Exit section inner surface of exit section 1 2,32, 52,72,92 Outlet hole 1 3,1 3a, 1 3b, 33,33 ,, 53,73,73 ,, 93,93, valve element 14 Locking member 1 5,3 5,5 5,7 5, 9 5 flow path 1 6,3 6,56,76,96 through hole U-64 -50- (48) 200404716 1 7,3 7,5 7,77,97 1 8,3 8,5 8,7 8 20? 2 0,940? 60? 80? 100 21,41,61,81,101 23.43.63.83.103 24.44.64.84.104 25,45,65,85,105 25,, 45,, 65,85 ,, 105, 26, 46, 66, 1 06 34a, 34a ?, 74 52a 52b 53a 53b 93a 93b 94a 94b

U

D Air filter Liquid filter container (eye dropper) The container body plug contains liquid droplets residual liquid cover valve seat flow path inner wall ridge portion valve body convex portion thin wall portion valve body valve element support member flange upstream side downstream Side-51-

Claims (1)

(1) (1) 200404716 Patent application scope 1. A conveying device comprising: an outlet portion having a substantially bottom tubular or substantially bowl shape, the shape having an outlet hole at its bottom; a valve element made of an elastic material It is made that when no liquid pressure is exerted on the upstream side from the upstream side, the flow path in the outlet hole and / or the outlet portion communicating with the outlet hole is closed, and when a liquid pressure is applied on the upstream side The upper side deforms and opens the outlet hole and / or the flow path, the side of the outlet hole is defined as a downstream; and a vent hole communicating with the outlet hole, the outlet hole is provided on the valve element through an air filter The upstream position of the valve element, wherein the deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the opening of the outlet hole and / or the flow path cannot be filtered by the air from the outside The air of the device is achieved by pressure. 2. A transfer device comprising: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at the bottom thereof; a valve element made of an elastic material and disposed at the outlet portion, When no liquid pressure is applied to it from the upstream side, the outlet hole is closed, and when liquid pressure is applied to it from the upstream side, it encounters compression deformation and opens the outlet hole, the side of the outlet hole Defined as downstream; a locking member disposed at the outlet portion to define a flow path between itself and the inner surface of the outlet portion, and fixing the valve element upstream; and -52- rtbb (2) (2) 200404716 A vent hole is communicated with the outlet hole, and the outlet hole is provided upstream of the valve element via an air filter, wherein the compression deformation of the valve element is caused by a liquid passing pressure lower than the air filter. The liquid pressure is achieved, and the opening of the outlet hole and / or the flow path cannot be achieved from the outside through the air passage pressure of the air filter. 3. The transfer device according to item 2 of the patent application scope, wherein the valve element and the locking member are integrally formed. 4. A conveying device comprising: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an * outlet hole at its bottom; a valve seat fixed to the outlet portion; a valve element, made of an elastic material It has a substantially tubular shape, and the valve element is fixed on the inner surface of the outlet portion. When no liquid pressure is applied thereto, it contacts from the downstream side through the valve seat to close the flow path communicating with the outlet hole. When a liquid pressure is applied to it from the upstream side, it undergoes compression deformation to open the flow path between itself and the valve seat, the outlet hole side is defined as the downstream; and a vent hole communicating with the outlet hole, the outlet hole Is arranged upstream of the valve element via an air filter, wherein the compression deformation of the valve element is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the outlet hole and / Or the opening of the flow path cannot be achieved from the outside by the air passage pressure of the air filter. -53 · (3) (3) 200404716 5 · The conveying device according to item 4 of the patent application scope, wherein the valve element and the outlet portion are integrally formed. 6. A conveying device comprising: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at its bottom; a valve element made of an elastic material and disposed at the outlet portion, when not When liquid pressure is applied from the upstream side, the outlet hole or the flow path communicating with the outlet hole is closed, and when liquid pressure is applied from the upstream side to the outlet hole, expansion deformation is performed to open the outlet hole. Or a flow path, the side of the outlet hole is defined as a downstream; and a vent hole communicating with the outlet hole, the outlet hole is provided upstream of the valve element via an air filter, wherein the valve element is inflated Deformation is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the opening of the outlet hole and / or the flow path cannot be achieved from the outside by the air passing pressure of the air filter. 7. The conveying device according to item 6 of the patent application, wherein the valve element has a valve body fixed to the flow path, and an end formed with a convex portion on the outlet hole side; a convex portion located at the end of the valve body From the downstream side to mesh with a ridge formed on the inner wall of the flow path to close the flow path, the ridge communicates with the outlet hole, and the valve body expands from the upstream side under liquid pressure and expands and deforms' To form a gap between -54- (4) (4) 200404716 between the convex portion at the end of the valve body and the ridge portion on the inner wall of the flow path. 8. A conveying device comprising: an outlet portion having a substantially bottomed tube or substantially bowl shape, the shape having an outlet hole at its bottom; a valve element 'made of an elastic material and the outlet on its outer surface When the liquid pressure is applied from the upstream side, the outlet hole is closed, and when the liquid pressure is applied from the upstream side, the outlet hole or the flow path is expanded and deformed. The side of the outlet hole is defined as a downstream; and a vent hole communicating with the outlet hole, the outlet hole is provided at an upstream position of the valve element via an air filter, wherein the expansion deformation of the valve element is borrowed Achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the opening of the outlet hole cannot be achieved from the outside by the air passing pressure of the air filter. 9. As for the scope of patent application, the 8th item A transmission device, wherein the outlet hole is defined by a substantially dish-shaped valve seat fixed to the outlet portion and an inner wall surface of the outlet portion holding the valve seat; the valve element There is a substantially annular thin-walled portion, and the thin-walled portion is brought into contact with the valve seat from the side of the outer surface of the outlet portion to close the outlet hole; and the thin-walled portion of the valve element is upstream from the liquid pressure The side faces downstream and expands and deforms to open the exit hole. 10. For the conveying device of item 9 in the scope of the patent application, the valve element -55- (5) (5) 200404716 pieces and the outlet unit are integrally formed. 11. A conveying device comprising: an outlet portion having a substantially bottom tubular or substantially bowl shape, the shape having an outlet hole at its bottom; a valve element, made of an elastic material, having a substantially annular valve body and a A substantially annular thin wall portion is provided at the end of the former. The valve system is fixed to the outlet portion, but the thin wall portion is exposed to the outside of the outlet portion through the hole; a cylindrical valve element supporting member is disposed at the outlet portion. An outlet hole and the valve element are defined; and a vent hole communicating with the outlet hole, the outlet hole is provided upstream of the valve element through an air filter, and the outlet hole side is defined as a downstream, wherein the valve The element makes its thin wall portion contact the outer periphery of the valve element supporting member so as to close the outlet hole when no liquid pressure is applied thereto from the upstream side, however, the thin wall portion is expanded and deformed so that when the liquid pressure When it is applied to it, the outlet hole is opened, and the expansion deformation of the thin wall portion is achieved by a liquid pressure lower than the liquid passing pressure of the air filter, and the outlet Not from the outer side of the opening of the air by the air filter to be reached by the pressure. 12. The conveying device according to item 11 of the patent application scope, wherein the valve element supporting member has a flange position on the upstream side of the circular portion, but the valve body of the valve element is in contact with the flange to When no liquid pressure is applied from the upstream side, the flow path is closed, and compression deformation is performed so that when liquid pressure is applied from the upstream side, it opens itself -56 · (6) 200404716 And the flow path between the valve element supporting members. 13. The conveying device according to item 11 of the application, wherein the valve element and the outlet portion are integrally formed. ^ 14. The conveying device according to item 12 of the patent application scope, wherein the valve element and the outlet portion are integrally formed. 1 5 · The conveying device according to any one of claims 2 to 14 in the scope of patent application, wherein an antibacterial treatment has been applied to the valve element. 16 · The conveying device according to any one of claims 2 to 14 in the scope of patent application, wherein an antibacterial treatment has been applied to the exit hole. 1 7 · If the conveying device of any of items 2 to 14 of the scope of patent application, a liquid thickener is provided upstream of the outlet hole, or the flow path is opened and closed by the valve element Location upstream. 18 · —A container having a transfer device according to any one of claims 1 to 17 of the scope of application for a patent, the transfer device being assembled in a mouth of a container body 19. The container according to item 18 of the scope of patent application, including a plug which is slidably held in the flow path of the conveying device or the container body, but the plug is in contact with the inner wall of the flow path of the conveying device So that the flow path is closed before the container is used. 20. The container according to any one of claims 18 or 19 in the scope of patent application, the container is an eyedropper. -57-