TW200300078A - Method of treating disorder related to high cholesterol concentration - Google Patents

Method of treating disorder related to high cholesterol concentration Download PDF

Info

Publication number: TW200300078A
Authority: TW; Taiwan
Prior art keywords: item; patent application; scope; compound; composition
Prior art date: 2001-11-08

Application number

TW091132850A

Other languages

English (en)

Chinese (zh)

Inventor

Shutsung Liao

Ching Song

Original Assignee

Univ Chicago

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-08

Filing date

2002-11-08

Publication date

2003-05-16

2002-11-08 Application filed by Univ Chicago filed Critical Univ Chicago

2003-05-16 Publication of TW200300078A publication Critical patent/TW200300078A/zh

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

TW091132850A 2001-11-08 2002-11-08 Method of treating disorder related to high cholesterol concentration TW200300078A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34802001P	2001-11-08	2001-11-08

Publications (1)

Publication Number	Publication Date
TW200300078A true TW200300078A (en)	2003-05-16

Family

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW091132850A TW200300078A (en)	2001-11-08	2002-11-08	Method of treating disorder related to high cholesterol concentration

Country Status (5)

Country	Link
EP (1)	EP1450816A4 (fr)
JP (1)	JP2005508368A (fr)
CA (1)	CA2466033A1 (fr)
TW (1)	TW200300078A (fr)
WO (1)	WO2003039480A2 (fr)

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* Cited by examiner, † Cited by third party
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US7078396B2 (en)	2001-05-03	2006-07-18	Arch Development Corporation	Method of treating disorder related to high cholesterol concentration
US8399441B2 (en)	2004-10-25	2013-03-19	Virginia Commonwealth University	Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (fr)	2004-10-25	2006-05-04	Virginia Commonwealth University	Oxysterol sulfate nucleaire, regulateur homeostatique du cholesterol agissant puissamment dans le traitement de l'hypercholesterolemie, de l'hyperlipidemie et de l'atherosclerose
KR101021828B1 (ko)	2004-10-27	2011-03-17	다이이찌 산쿄 가부시키가이샤	2 이상의 치환기를 갖는 벤젠 화합물
US7902240B2 (en)	2006-11-13	2011-03-08	Novartis Ag	Substituted pyrazole and triazole compounds as KSP inhibitors
US8829213B2 (en)	2009-07-29	2014-09-09	The University Of Chicago	Liver X receptor agonists
US9034859B2 (en)	2011-04-06	2015-05-19	Virginia Commonwealth University	Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
WO2013036835A1 (fr) *	2011-09-08	2013-03-14	Sage Therapeutics, Inc.	Stéroïdes neuroactifs, compositions et leurs utilisations
RS67266B1 (sr)	2013-03-13	2025-10-31	Sage Therapeutics Inc	Neuroaktivni steroidi i postupci za njihovu upotrebu
RU2021111681A (ru) *	2013-03-13	2021-05-11	Сейдж Терапьютикс, Инк.	Нейроактивные стероиды, композиции и их применение
JP2016193835A (ja) *	2013-09-04	2016-11-17	学校法人常翔学園	核内受容体肝臓ｘ受容体アゴニスト
SMT202200094T1 (it)	2013-12-24	2022-05-12	Univ Virginia Commonwealth	Uso di solfati di colesterolo ossigenati (ocs) per il trattamento dell’insufficienza epatica acuta
WO2015195967A1 (fr)	2014-06-18	2015-12-23	Sage Therapeutics, Inc.	Oxystérols et leurs procédés d'utilisation
SMT202100476T1 (it)	2015-07-06	2021-09-14	Sage Therapeutics Inc	Ossisteroli e metodi di uso degli stessi
JP6882996B2 (ja)	2015-07-06	2021-06-02	セージセラピューティクス，インコーポレイテッド	オキシステロールおよびそれらの使用の方法
BR112018000129B1 (pt)	2015-07-06	2024-01-09	Sage Therapeutics, Inc	Compostos oxiesteróis, seus usos e composição farmacêutica
SI3436022T1 (sl)	2016-04-01	2022-08-31	Sage Therapeutics, Inc.	Oksisteroli in postopki za uporabo le-teh
WO2017193046A1 (fr)	2016-05-06	2017-11-09	Sage Therapeutics, Inc.	Oxystérols et méthodes d'utilisation associées
ES2884071T3 (es)	2016-07-07	2021-12-10	Sage Therapeutics Inc	24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
WO2018026781A1 (fr)	2016-08-02	2018-02-08	Virginia Commonwealth University	Compositions comprenant du 5-cholestène-3, 25-diol,3-sulfate (25 h3s) ou un sel pharmaceutiquement acceptable de celui-ci et au moins un oligosaccharide cyclique
MX392270B (es)	2016-09-30	2025-03-24	Sage Therapeutics Inc	Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
CN110267966B (zh)	2016-10-18	2022-07-08	萨奇治疗股份有限公司	氧甾醇及其使用方法
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2002
- 2002-11-08 WO PCT/US2002/035900 patent/WO2003039480A2/fr not_active Ceased
- 2002-11-08 CA CA002466033A patent/CA2466033A1/fr not_active Abandoned
- 2002-11-08 EP EP02802882A patent/EP1450816A4/fr not_active Withdrawn
- 2002-11-08 JP JP2003541772A patent/JP2005508368A/ja active Pending
- 2002-11-08 TW TW091132850A patent/TW200300078A/zh unknown

Also Published As

Publication number	Publication date
CA2466033A1 (fr)	2003-05-15
EP1450816A2 (fr)	2004-09-01
JP2005508368A (ja)	2005-03-31
WO2003039480A3 (fr)	2003-06-19
WO2003039480A2 (fr)	2003-05-15
EP1450816A4 (fr)	2008-02-13

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