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TR201904866T4 - Polipeptidler ve polinükleotidler ve bunların ilaç ve biyolojik madde üretmek için bir ilaç hedefi olarak kullanımları. - Google Patents

Polipeptidler ve polinükleotidler ve bunların ilaç ve biyolojik madde üretmek için bir ilaç hedefi olarak kullanımları. Download PDF

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Publication number
TR201904866T4
TR201904866T4 TR2019/04866T TR201904866T TR201904866T4 TR 201904866 T4 TR201904866 T4 TR 201904866T4 TR 2019/04866 T TR2019/04866 T TR 2019/04866T TR 201904866 T TR201904866 T TR 201904866T TR 201904866 T4 TR201904866 T4 TR 201904866T4
Authority
TR
Turkey
Prior art keywords
polynucleotides
polypeptides
biological material
cancer
drug target
Prior art date
Application number
TR2019/04866T
Other languages
English (en)
Inventor
Levine Zurit
Rosenberg Avi
Rotman Galit
Novik Amit
Toporik Amir
Kinar Yaron
Nemzer Sergey
Koifman Cynthia
Beiman Merav
Dassa Liat
Walach Shira
Montia Eve
Sameach-Greenwald Shirley
Pergam Tania
Milo Dalit
Cohen-Dayag Anat
Levy Ofer
Bubis Marina
Original Assignee
Compugen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compugen Ltd filed Critical Compugen Ltd
Publication of TR201904866T4 publication Critical patent/TR201904866T4/tr

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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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Abstract

Bu buluş, immün ve immün olmayan bazlı terapötik ajanların üretimi ve hastalık tanısı için yeni bir hedef ile ilgilidir. Daha özel olarak, buluş, ko-stimülatör familya üyeleri olarak tahmin edilen ve akciğer kanseri, yumurtalık kanseri ve kolon kanserini içeren kanserlerde diferansiyel olarak eksprese edilen C1ORF32 antijenlerine karşı terapötik antikorlar ve tanı ve terapötik kullanımlarını sağlar. Bu antikorların B7 kostimülasyonunu modüle etmek için kullanımı da sağlanmaktadır. Bu buluş ayrıca C1ORF32'nin hücre dışı alanlarının ve bunun kanser tedavisi ve ilaç gelişimi için uygun hedefler olan varyantlarının keşfi ile de ilgilidir.
TR2019/04866T 2007-09-04 2008-09-03 Polipeptidler ve polinükleotidler ve bunların ilaç ve biyolojik madde üretmek için bir ilaç hedefi olarak kullanımları. TR201904866T4 (tr)

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