TR201603771A2 - Obesity-inducing rodent feed. - Google Patents

Abstract

The invention relates to the production of rodent feed from most fat, which will allow rapid weight gain and fat in experimental animals in scientific research on obesity. The feed produced contains essential oil and fructose in addition to the essential nutrient sources for animals. Pellet-like feed tablets were obtained by melting the internal fat of the fructose with its crystalline and sticky properties, followed by freezing the pressed feed. Fast-weight gain and fat in the abdomen were detected in the rodents fed feed produced in a short time. Product; It is a feed which has very different properties in terms of content and production technique compared to the previous high energy feeds.

Description

DESCRIPTION Obesity-inducing rodent food Technical Area: Invention, examination of studies in the field of medicine on experimental animals It is about producing special feed for the experimental animal model that needs to be created for the purpose. The produced feed was developed to create an obese diabetes rodent model.

Rodent animals have been used in therapeutic studies on obesity and type 2 diabetes. The creation of models is of great importance. In this direction, obesity and its similar to the occurrence of metabolic disorders in humans, depending on the must be created on the models. For this, obesity inducer to increase fat in animals by feeding with feeds and then metabolic Strategies to induce deterioration of parameters should be developed. This purpose In line with obesity and diabetes studies, rodents have high calorie and In particular, feeds in which the calorie source is provided by fat have been developed. These feeds are Among the feeds developed by different companies although their contents are similar. Raw materials used as both fat content and carbohydrate and protein source There are differences on the basis. However, these high-fat feeds Production is carried out in Europe and America. High oil content in our country a company that produces experimental animal feed or a formulated product does not exist. In general, international studies on obesity and diabetes the most commonly used high-fat feeds in the articles, GO% of calories from fat consists of feed. One of the most commonly used of these feeds is Research Diets. D12492 coded rodent bait produced by the company. This oath is made by the firm itself. It differs from the standard feed it produces, contains corn starch and used sucrose and pork. the amount of oil has been increased. Based on these studies, production in our country experimental animal feed in our country for the production of high-fat feed that is not made feed with high fat content by making additions to the basic pellet feeds used as We did a content research for its formulation. The most important issue regarding the production of high fat feed The limiting condition was the requirement for rodents to consume pellet feed for oral and dental health.

As the fat content increases in feed production, pelletizing the feed is already existing. not possible under production conditions. Also, the oil to be used is of animal origin. It is a factor that increases lubrication and induces obesity more. Animal fats in solid form are more difficult to add to the feed. is happening. Animal fat in our reference D12492 rodent feed Pig fat is used as a source. We supply the feed we produce in our country. Stuffed (frost) oil obtained from sheep and cattle, which are easier to obtain we used Protein and carbohydrate in feeds produced by Research Diets Casein, Corn Starch, Maltodextrin, Sucrose, Soybean oil were used as the source. The feeds are made into pellets with the addition of vitamins and minerals. This When the ratios in the feeds are considered, it is seen that 60% of the calories originate from fat.

The feed content we produce; alfalfa flour as a source of protein and carbohydrates, In addition to corn, wheat, barley, bonkalite, soybean oil, it contains essential vitamins and minerals. is formed. In addition, essential oil is used to provide high oil content. in this bait Another of the most important differences is that it contains Fructose. Fructose, especially compared to sucrose Obesity and obesity as it induces abdominal fattening and liver fattening more. It is more effective in creating metabolic disorders. For pelletizing feed Since increasing the oil ratio in the systems used poses a problem, this ratio We have developed a production technique that will make it possible to increase Solidly supplied interior After the oil is chopped, it is first melted and then fed with powder feed containing fructose. After mixing, this mixture is compressed by pressing and then by freezing, pellet-like layers that are hard enough to be gnawed by mice and rats. (tablets) has been created. In addition to the ability of the essential oil to be freezeable, When the crystalline and sticky properties of fructose come together, its calorie is 77% fat. It is possible to produce a rodent food sourced in hard layers (tablets). has been. Along with this fat content, carbohydrate, protein and vitamin contents When evaluated, abdominal fattening, weight gain and weight gain in animals fed with this feed Except for metabolic disorders, any nutrient imbalance that may result from No negative effects were observed. In this regard, the protein and carbohydrate content Obesity-inducing rodent that is well-balanced and contains high animal fat The production of the feed is provided.

Description of the invention: trays are used. Since these trays have a capacity of 2 kg, the mixtures are in 2 kg batches. was prepared. It is completely solid when made. To be added to the powder mix, it must first be liquefied. must be brought. However, melting process to large fat masses in solid state There is a risk of burning these masses at high temperatures. Also, melt While it is expected to be fully realized, the parts that melt will also be required for a long time. The probability of evaporation is high. For this reason, the supplied tallow is first turned into ground beef. is brought. completely melted.

.The inner oil will freeze when the mixture cools down. poured on it. compressed by pressing. placed and waiting for it to freeze. cut into similar tablets.

.Feed tablets are packed when ready and kept until the animals are fed. It is stored at -2OC. After it is brought to the temperature, it becomes ready for use.

How the invention is applied to industry: High-fat rodent chow to create a diabetes and obese rodent model It is a type of feed that needs to be used for the purpose. Various kinds of food produced with logic similar to this bait feeds are produced in foreign countries. However, in our country, there are foods with similar content to this food. or any other rodent bait with a high fat content is not produced. Most of this The main reason is that it is used for pelletizing feed with high oil content. not being able to pass through pellet machines and being softer than the required consistency because it cannot be made into pellets. However, the fructose used in the feed produced With its sticky and crystallized feature, the tallow is first melted and then hot. adding it to the feed mix; to ensure that the consistency of the feed is compressible. it provides. In addition, instead of making pellets, pressing and then freezing method used, this problem disappears. All these techniques on a small scale Although it seems possible to manufacture If the necessary equipment is provided, it will be a product that can be produced much more easily. foreseen.

In line with this idea, the oil melted in a large pan melting system is a large After pouring into the mixer and mixing with powder feed and fructose, it is transferred to the walking bands. after compaction of the feed to be poured with a high-weight press machine placed in the freezer and then cut into the desired size with cutting mechanisms. By cutting and packaging, high amount of production can be achieved in a short time. This production Afterwards, the packed feeds can be taken out for distribution. This way across the country Since it is not a feed in production, it is for researchers who will study obesity and diabetes. Large-scale supply can be achieved. It is also used abroad in terms of content. More abdominal fattening due to being different from feeds and fructose content It can also be preferred by researchers abroad. Therefore The product may also have export potential.

Claims (8)

REQUESTS 1) Invention is a feed produced for rodents fed in experimental animal laboratories. It has a high calorie content and 77% of its calories are from animal fat. 2) According to claim 1, it is a rodent bait with high oil content and its feature is; It contains fructose as a carbohydrate source. 3) Invention is a rodent bait production method and its feature is; - melting the tallow - thickening the mixture with the combination of tructose and tallow - pressing the feed mixture - cutting the pressed feed layers. 4) It is a rodent bait production method in accordance with claim Sie and its feature is; It is the fact that the tallow used in the melting phase of the tallow is made into minced meat beforehand. 5) It is a rodent feed production method in accordance with claim Si, and its feature is that it includes the step of adding tallow to the powder feed tructose mixture while it is hot. 6) It is a rodent feed production method in accordance with Claim Sie, and its feature is that it includes the pressing step of the prepared feed mixture. 7) It is a rodent bait production method in accordance with Claim 3, and its feature is that it includes the freezing step of the pressed feed. 8) It is a rodent feed production method in accordance with Claim 3, and its feature is that it includes the step of cutting the pressed-frozen feed after freezing.