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TR200201168T2 - CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri. - Google Patents

CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri.

Info

Publication number
TR200201168T2
TR200201168T2 TR2002/01168T TR200201168T TR200201168T2 TR 200201168 T2 TR200201168 T2 TR 200201168T2 TR 2002/01168 T TR2002/01168 T TR 2002/01168T TR 200201168 T TR200201168 T TR 200201168T TR 200201168 T2 TR200201168 T2 TR 200201168T2
Authority
TR
Turkey
Prior art keywords
cgrp
cyclopropanes
antagonists
production methods
drugs containing
Prior art date
Application number
TR2002/01168T
Other languages
English (en)
Inventor
Eberlein Wolfgang
Engel Wolfhard
Rudolf Klaus
Doods Henri
Hallermayer Gerhard
Bauer Eckhart
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of TR200201168T2 publication Critical patent/TR200201168T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Elde bulunan bulus, genel formül (I)'in bilesiklerini kapsamaktadir, bunun içerisinde R ve R istem 1'deki gibi açiklanmistir ve bunlarin tautomerleri, bunlarin diastereomerleri, bunlarin enantiyomerleri, bunlarin karisimlari ve bunlarin tuzlari, özellikle bunlarin fizyolojik açidan tolere edilebilen tuzlari, degerli farmakolojik özelliklere, özellikle CGRP-antagonistik özelliklere sahip olan anorganik veya organik asitler ve bazlari ile bu bilesikleri içeren ilaçlar, bunlarin kullanim sekli ve üretiminde gidilen yöntemleri kapsamaktadir. formül (1)
TR2002/01168T 1999-10-29 2000-10-21 CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri. TR200201168T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19952147A DE19952147A1 (de) 1999-10-29 1999-10-29 Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
TR200201168T2 true TR200201168T2 (tr) 2002-08-21

Family

ID=7927315

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01168T TR200201168T2 (tr) 1999-10-29 2000-10-21 CGRP-Antagonistleri-yeni siklopropanlar içeren ilaçlar ve üretim yöntemleri.

Country Status (26)

Country Link
US (2) US20030139417A1 (tr)
EP (1) EP1228059B1 (tr)
JP (1) JP3869721B2 (tr)
KR (1) KR20020047290A (tr)
CN (1) CN1177844C (tr)
AT (1) ATE301117T1 (tr)
AU (1) AU781856B2 (tr)
BG (1) BG106638A (tr)
BR (1) BR0015147A (tr)
CA (1) CA2387134C (tr)
CZ (1) CZ20021812A3 (tr)
DE (2) DE19952147A1 (tr)
EA (1) EA005137B1 (tr)
EE (1) EE200200220A (tr)
HR (1) HRP20020373A2 (tr)
HU (1) HUP0203496A3 (tr)
IL (1) IL148975A0 (tr)
MX (1) MXPA02004119A (tr)
NO (1) NO20021799D0 (tr)
NZ (1) NZ518698A (tr)
PL (1) PL354715A1 (tr)
SK (1) SK7282002A3 (tr)
TR (1) TR200201168T2 (tr)
WO (1) WO2001032648A1 (tr)
YU (1) YU30902A (tr)
ZA (1) ZA200203256B (tr)

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US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
CN100558728C (zh) 2002-06-05 2009-11-11 布里斯托尔-迈尔斯斯奎布公司 降钙素基因相关肽受体拮抗剂
US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
JP2007524568A (ja) 2003-12-05 2007-08-30 ブリストル−マイヤーズ　スクイブ　カンパニー カルシトニン遺伝子関連ペプチドレセプターアンタゴニスト
US7569578B2 (en) 2003-12-05 2009-08-04 Bristol-Meyers Squibb Company Heterocyclic anti-migraine agents
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
CA2580020A1 (en) * 2004-09-09 2006-03-23 Ian M. Bell Aryl spirolactam cgrp receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
WO2007061677A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
EA201000612A1 (ru) 2007-10-18 2010-10-29 Бёрингер Ингельхайм Интернациональ Гмбх Антагонисты cgrp-пептиды
EP2225223B1 (de) 2007-11-22 2017-01-11 Boehringer Ingelheim International GmbH Organische verbindungen
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2833879A4 (en) 2012-04-05 2016-03-02 Chdi Foundation Inc CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF
EP3049389B1 (en) 2013-09-26 2019-08-07 CHDI Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2016536350A (ja) 2013-09-26 2016-11-24 シーエイチディーアイ ファウンデーション，インコーポレーテッド キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法
JP2019040859A (ja) * 2017-08-22 2019-03-14 株式会社エンプラス 発光装置、面光源装置および光束制御部材
CN114957145B (zh) * 2022-04-14 2023-07-18 浙江师范大学 一种1,2,4-苯并三嗪衍生物及其制备方法

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Also Published As

Publication number Publication date
US7407963B2 (en) 2008-08-05
CZ20021812A3 (cs) 2002-08-14
CN1387526A (zh) 2002-12-25
BG106638A (bg) 2003-01-31
EP1228059A1 (de) 2002-08-07
US20050267137A1 (en) 2005-12-01
NZ518698A (en) 2004-12-24
EE200200220A (et) 2003-06-16
KR20020047290A (ko) 2002-06-21
HRP20020373A2 (en) 2003-10-31
YU30902A (sh) 2005-07-19
HK1051858A1 (en) 2003-08-22
HUP0203496A2 (hu) 2003-02-28
WO2001032648A1 (de) 2001-05-10
DE50010886D1 (de) 2005-09-08
NO20021799L (no) 2002-04-17
JP2003513087A (ja) 2003-04-08
HUP0203496A3 (en) 2004-01-28
DE19952147A1 (de) 2001-05-03
ATE301117T1 (de) 2005-08-15
AU7921300A (en) 2001-05-14
MXPA02004119A (es) 2003-10-06
BR0015147A (pt) 2002-07-16
EP1228059B1 (de) 2005-08-03
US20030139417A1 (en) 2003-07-24
CA2387134C (en) 2008-07-08
CN1177844C (zh) 2004-12-01
EA200200447A1 (ru) 2002-10-31
JP3869721B2 (ja) 2007-01-17
ZA200203256B (en) 2003-04-10
SK7282002A3 (en) 2002-11-06
AU781856B2 (en) 2005-06-16
NO20021799D0 (no) 2002-04-17
PL354715A1 (en) 2004-02-09
CA2387134A1 (en) 2001-05-10
EA005137B1 (ru) 2004-12-30
IL148975A0 (en) 2002-11-10

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