TR200103405T2 - Bifunctional antibodies and their use in targeting tumor-inhibiting agents. - Google Patents
Bifunctional antibodies and their use in targeting tumor-inhibiting agents.Info
- Publication number
- TR200103405T2 TR200103405T2 TR2001/03405T TR200103405T TR200103405T2 TR 200103405 T2 TR200103405 T2 TR 200103405T2 TR 2001/03405 T TR2001/03405 T TR 2001/03405T TR 200103405 T TR200103405 T TR 200103405T TR 200103405 T2 TR200103405 T2 TR 200103405T2
- Authority
- TR
- Turkey
- Prior art keywords
- inhibiting agents
- bifunctional antibodies
- targeting tumor
- treatment
- targeting
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 230000001588 bifunctional effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Bir iki islevli antikar bir hedef mahalline yönelik olarak birlesme egilimine ve bir sitotoksik amile ya da bir ön ilaci bunun kendisine iat sitotiksik biçim içerisine dönüstürme yeterliliginde olan bir bir enzime kovalent olarak baglanmis olan bir organik moleküle yönelik olarak birlesme egilimine sahip bulunmaktadir. Ankikor, tedavi ya da teshiste, özellikle de, tümörlerin tedavi edilmesinde kullanilabilmektedir.A bi-functional antibody has a tendency to fuse for a target site and an organic molecule covalently linked to a cytotoxic agent or an enzyme capable of converting a prodrug into a cytotic form thereof. Ankikor can be used in treatment or diagnosis, especially in the treatment of tumors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9819411.1A GB9819411D0 (en) | 1998-09-04 | 1998-09-04 | Antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200103405T2 true TR200103405T2 (en) | 2002-06-21 |
Family
ID=10838416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/03405T TR200103405T2 (en) | 1998-09-04 | 1999-09-06 | Bifunctional antibodies and their use in targeting tumor-inhibiting agents. |
| TR2001/00651T TR200100651T2 (en) | 1998-09-04 | 1999-09-06 | Bifunctional antibodies and their use in targeting tumor-inhibiting agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00651T TR200100651T2 (en) | 1998-09-04 | 1999-09-06 | Bifunctional antibodies and their use in targeting tumor-inhibiting agents |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1107995A2 (en) |
| JP (1) | JP2002524470A (en) |
| KR (1) | KR20010072988A (en) |
| CN (1) | CN1315967A (en) |
| AU (1) | AU5641299A (en) |
| BG (1) | BG105293A (en) |
| BR (1) | BR9913429A (en) |
| CA (1) | CA2341753A1 (en) |
| EA (1) | EA200100311A1 (en) |
| GB (1) | GB9819411D0 (en) |
| HR (1) | HRP20010154A2 (en) |
| HU (1) | HUP0104091A2 (en) |
| ID (1) | ID28873A (en) |
| IL (1) | IL141524A0 (en) |
| MX (1) | MXPA01002349A (en) |
| NO (1) | NO20011102L (en) |
| PL (1) | PL346861A1 (en) |
| TR (2) | TR200103405T2 (en) |
| WO (1) | WO2000014119A2 (en) |
| ZA (1) | ZA200101574B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| WO2019228514A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
| US20210309745A1 (en) * | 2018-07-26 | 2021-10-07 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| WO2020151572A1 (en) | 2019-01-23 | 2020-07-30 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-l1 diabodies and the use thereof |
| CN110811820B (en) * | 2019-12-11 | 2022-07-12 | 江西华晨医疗设备有限公司 | Straight rod type flushing and suction electrocoagulation cutter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
| US5217713A (en) * | 1988-12-27 | 1993-06-08 | Takeda Chemical Industries, Ltd. | Cytotoxic bispecific monoclonal antibody, its production and use |
| EP0505566A1 (en) * | 1989-12-15 | 1992-09-30 | Takeda Chemical Industries, Ltd. | Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics |
| JPH05184383A (en) * | 1990-06-19 | 1993-07-27 | Dainabotsuto Kk | Bispecific antibody |
| WO1998038513A1 (en) * | 1997-02-26 | 1998-09-03 | Khaw Ban An | Signal enhancement of bispecific antibody-polymer probe for immunoassay use |
-
1998
- 1998-09-04 GB GBGB9819411.1A patent/GB9819411D0/en not_active Ceased
-
1999
- 1999-09-06 PL PL99346861A patent/PL346861A1/en not_active Application Discontinuation
- 1999-09-06 HU HU0104091A patent/HUP0104091A2/en unknown
- 1999-09-06 JP JP2000568876A patent/JP2002524470A/en active Pending
- 1999-09-06 TR TR2001/03405T patent/TR200103405T2/en unknown
- 1999-09-06 ID IDW20010752A patent/ID28873A/en unknown
- 1999-09-06 EA EA200100311A patent/EA200100311A1/en unknown
- 1999-09-06 IL IL14152499A patent/IL141524A0/en unknown
- 1999-09-06 BR BR9913429-2A patent/BR9913429A/en not_active IP Right Cessation
- 1999-09-06 TR TR2001/00651T patent/TR200100651T2/en unknown
- 1999-09-06 KR KR1020017002437A patent/KR20010072988A/en not_active Withdrawn
- 1999-09-06 CN CN99810368A patent/CN1315967A/en active Pending
- 1999-09-06 EP EP99943138A patent/EP1107995A2/en not_active Withdrawn
- 1999-09-06 WO PCT/GB1999/002938 patent/WO2000014119A2/en not_active Ceased
- 1999-09-06 MX MXPA01002349A patent/MXPA01002349A/en not_active Application Discontinuation
- 1999-09-06 HR HR20010154A patent/HRP20010154A2/en not_active Application Discontinuation
- 1999-09-06 CA CA002341753A patent/CA2341753A1/en not_active Abandoned
- 1999-09-06 AU AU56412/99A patent/AU5641299A/en not_active Abandoned
-
2001
- 2001-02-26 BG BG105293A patent/BG105293A/en unknown
- 2001-02-26 ZA ZA200101574A patent/ZA200101574B/en unknown
- 2001-03-02 NO NO20011102A patent/NO20011102L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1315967A (en) | 2001-10-03 |
| ID28873A (en) | 2001-07-12 |
| NO20011102L (en) | 2001-03-05 |
| IL141524A0 (en) | 2002-03-10 |
| TR200100651T2 (en) | 2001-07-23 |
| HRP20010154A2 (en) | 2002-02-28 |
| NO20011102D0 (en) | 2001-03-02 |
| JP2002524470A (en) | 2002-08-06 |
| PL346861A1 (en) | 2002-03-11 |
| EP1107995A2 (en) | 2001-06-20 |
| BG105293A (en) | 2001-12-29 |
| AU5641299A (en) | 2000-03-27 |
| WO2000014119A3 (en) | 2000-11-30 |
| GB9819411D0 (en) | 1998-10-28 |
| KR20010072988A (en) | 2001-07-31 |
| WO2000014119A2 (en) | 2000-03-16 |
| ZA200101574B (en) | 2002-02-26 |
| HUP0104091A2 (en) | 2002-03-28 |
| CA2341753A1 (en) | 2000-03-16 |
| BR9913429A (en) | 2001-09-25 |
| EA200100311A1 (en) | 2001-08-27 |
| MXPA01002349A (en) | 2003-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE383430T1 (en) | RECOMBINANT ANTIBODIES AND IMMUNE CONJUGATES TARGETED AT CD22-BEARING CELLS AND TUMORS | |
| EP1071460A4 (en) | ERBB2 INTERNALIZATION ANTIBODIES | |
| Krall et al. | A small‐molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors | |
| DE69830326D1 (en) | IMINING POLYSACCHARIDES, THEIR PREPARATION AND USE AS ADDITIVES AND IMMUNOSTIMULATING AGENTS | |
| FI982422A0 (en) | Porphyrin compounds, their conjugates and assay methods based on the use of said conjugate | |
| WO2004018000A3 (en) | Compositions and methods for treating cancer using maytansinoid cd44 antibody immonoconjugates and chemotherapeutic agents | |
| EA200400179A1 (en) | TREATMENT AND DIAGNOSTIC CANCER | |
| CY1111863T1 (en) | OPTIONS AGAINST DEATH RECEPTOR 4 (DR4) AND THEIR USES | |
| EP2357006A3 (en) | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease | |
| CY1113370T1 (en) | ADMINISTRATIVE MEDICINE PREPARATION CONSIDERED BY A CELLULAR AND A MALLEMINAL GROUP CONNECTED TO AN INTERMEDIATE | |
| DE60033658D1 (en) | TREATMENT OF PROSTATE CANCER WITH ANTI-ERBB2 ANTIBODIES | |
| DE69737867D1 (en) | TARGETED COMBINATION IMMUNOTHERAPY FOR CANCER | |
| IL187389A0 (en) | Nucleic acid molecule encoding a conjugate for treating activated immune cells | |
| TR200003161T2 (en) | Polyol-IFN-Beta conjugates | |
| ATE415979T1 (en) | TREATMENT WITH ANTI-ERBB2 ANTIBODIES | |
| AR035977A1 (en) | IMMUNOCONJUGADOS OF ANTIBODIES CD44 CITOTOXICOS. | |
| RU92016354A (en) | COMPOSITION, METHODS OF TREATMENT, METHOD OF PREVENTION OF RECURRENCE, METHOD OF ENHANCING CYTOTOXIC ACTIVITY OF IMMUNOTOXIN, METHOD OF ENHANCING CYTOTOXIC ACTION OF CONJUGATE | |
| ATE304709T1 (en) | SUBSTANCES WITH BRANCHED LINKER MOLECULES | |
| FI924605A0 (en) | ANTIKROPPONJUGATER FOER BEHANDLING AV NEOPLASTISKA SJUKDOMAR | |
| TR200102041T2 (en) | 2-arylmino heterocycles substituted as progesterone receptor binding agents | |
| ATE192047T1 (en) | BICYLCLIC, POLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, CONJUGATES, PREPARATION AND USE AS CONTRAST MATERIALS | |
| TR200103405T2 (en) | Bifunctional antibodies and their use in targeting tumor-inhibiting agents. | |
| DE69921486D1 (en) | DEXTRAN-LEPTIN CONJUGATES, PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS | |
| Maison et al. | Improved chemical strategies for the targeted therapy of cancer | |
| TR200102944T2 (en) | Integrin receptor ligands |