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TR200101598T2 - Thyurea inhibitors of herpes viruses. - Google Patents

Thyurea inhibitors of herpes viruses.

Info

Publication number
TR200101598T2
TR200101598T2 TR2001/01598T TR200101598T TR200101598T2 TR 200101598 T2 TR200101598 T2 TR 200101598T2 TR 2001/01598 T TR2001/01598 T TR 2001/01598T TR 200101598 T TR200101598 T TR 200101598T TR 200101598 T2 TR200101598 T2 TR 200101598T2
Authority
TR
Turkey
Prior art keywords
carbon atoms
thyurea
inhibitors
herpes viruses
heterocycloalkyl
Prior art date
Application number
TR2001/01598T
Other languages
Turkish (tr)
Inventor
David Bloom Jonathan
Joseph Digrandi Martin
George Dushin Russell
Albert Lang Stanley
Mark O'hara Bryan
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of TR200101598T2 publication Critical patent/TR200101598T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formül (I)'in bilesimleri, burada R1-R5 bagimsiz olarak hidrojen, 1 ila 6 atomlu alkil, 2 ila 6 karbon atomlu alkenil, 2 ila 6 karbon atomlu alkinil, 1 ila 6 karbon atomlu perhaloalkil, 3 ila 10 karbon atomlu sikloalkil, 3 ila 10 karbon elemanli heterosikloalkil, aril, heteroaril, halojen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6,-SO2R6,-CONR7R8,-NR6(R7R8), -N(R7R8) ya da W-Y-(CH2)n-Z'den seçilir ya da R2 ve R3 ya da R3 ve R4 birlikte alinir ve 3 ila 7 elemanli heterosikloalkil ya da 3 ila 7 elemanli heteroarilden seçilir.Compounds of formula (I) wherein R1-R5 are independently hydrogen, alkyl of 1 to 6 atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, Heterocycloalkyl with 3 to 10 carbon elements, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SO2R6, -CONR7R8, -NR6 (R7R8), -N (R7R8) or WY- (CH2) is selected from n-Z, or R2 and R3 or R3 and R4 are taken together and selected from 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl.

TR2001/01598T 1998-12-09 1999-12-06 Thyurea inhibitors of herpes viruses. TR200101598T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
TR200101598T2 true TR200101598T2 (en) 2001-10-22

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01598T TR200101598T2 (en) 1998-12-09 1999-12-06 Thyurea inhibitors of herpes viruses.

Country Status (18)

Country Link
EP (1) EP1140913A1 (en)
JP (1) JP2002531558A (en)
KR (1) KR20010086082A (en)
CN (1) CN1335843A (en)
AU (1) AU756043B2 (en)
BG (1) BG105580A (en)
BR (1) BR9916042A (en)
CA (1) CA2351390A1 (en)
CZ (1) CZ20011958A3 (en)
EA (1) EA200100637A1 (en)
HU (1) HUP0104758A3 (en)
ID (1) ID29064A (en)
IL (1) IL143203A0 (en)
NO (1) NO20012836L (en)
PL (1) PL348177A1 (en)
SK (1) SK7692001A3 (en)
TR (1) TR200101598T2 (en)
ZA (1) ZA200104373B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE309237T1 (en) * 1999-03-12 2005-11-15 Boehringer Ingelheim Pharma AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY ACTIVES
JP3938651B2 (en) * 2000-04-13 2007-06-27 セントラル硝子株式会社 Process for producing optically active α-methyl-bis-3,5- (trifluoromethyl) benzylamine
WO2005000795A2 (en) * 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
JP2009506125A (en) * 2005-08-29 2009-02-12 ジェラルド・エム・ハウシー Theramutein modulator
CN108642926B (en) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 A kind of thiourea derivative for polyester dyeing and cleaning and its preparation method
US12479798B2 (en) 2019-11-19 2025-11-25 Takeda Pharmaceutical Company Limited Method for producing pyrrolidine compound

Also Published As

Publication number Publication date
KR20010086082A (en) 2001-09-07
SK7692001A3 (en) 2002-09-10
JP2002531558A (en) 2002-09-24
EP1140913A1 (en) 2001-10-10
AU3112200A (en) 2000-06-26
AU756043B2 (en) 2003-01-02
PL348177A1 (en) 2002-05-06
ID29064A (en) 2001-07-26
NO20012836L (en) 2001-08-08
BR9916042A (en) 2001-12-04
CA2351390A1 (en) 2000-06-15
CN1335843A (en) 2002-02-13
CZ20011958A3 (en) 2001-10-17
ZA200104373B (en) 2002-09-18
BG105580A (en) 2002-01-31
EA200100637A1 (en) 2001-12-24
IL143203A0 (en) 2002-04-21
HUP0104758A2 (en) 2002-04-29
HUP0104758A3 (en) 2002-05-28
NO20012836D0 (en) 2001-06-08

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