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TR200003828T2 - Fermentation process to produce clavulanic acid at a low concentration of free amino acids - Google Patents

Fermentation process to produce clavulanic acid at a low concentration of free amino acids

Info

Publication number
TR200003828T2
TR200003828T2 TR2000/03828T TR200003828T TR200003828T2 TR 200003828 T2 TR200003828 T2 TR 200003828T2 TR 2000/03828 T TR2000/03828 T TR 2000/03828T TR 200003828 T TR200003828 T TR 200003828T TR 200003828 T2 TR200003828 T2 TR 200003828T2
Authority
TR
Turkey
Prior art keywords
amino acids
free amino
low concentration
fermentation process
clavulanic acid
Prior art date
Application number
TR2000/03828T
Other languages
Turkish (tr)
Inventor
Theodorus Antonius Maria De Laat Wilhelmus
Krabben Preben
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of TR200003828T2 publication Critical patent/TR200003828T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

BIr Streptomyces türünün fermentasyonu ile ikincil metabolitlerin üretimi için gelistirilmis bir yöntem anlatilmistir. Serbest amino asitlerinin konsantrasyonu düsük tutuldugu takdirde, sasirtici ölçüde yüksek bir verim elde edilmektedir.An improved method for the production of secondary metabolites by fermentation of the BIr Streptomyces strain is described. A surprisingly high yield is achieved if the concentration of free amino acids is kept low.

TR2000/03828T 1998-07-03 1999-07-01 Fermentation process to produce clavulanic acid at a low concentration of free amino acids TR200003828T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98202264 1998-07-03

Publications (1)

Publication Number Publication Date
TR200003828T2 true TR200003828T2 (en) 2001-06-21

Family

ID=8233894

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03828T TR200003828T2 (en) 1998-07-03 1999-07-01 Fermentation process to produce clavulanic acid at a low concentration of free amino acids

Country Status (7)

Country Link
EP (1) EP1097238A1 (en)
CN (1) CN1308682A (en)
AU (1) AU5409799A (en)
CA (1) CA2336363A1 (en)
MX (1) MXPA00012930A (en)
TR (1) TR200003828T2 (en)
WO (1) WO2000001840A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1122305A1 (en) * 2000-01-31 2001-08-08 Dsm N.V. Glutamate dehydrogenase-transformed streptomyces clavuligerus with an improved capacity to assimilate ammonia
WO2009138994A1 (en) * 2008-05-14 2009-11-19 Biocon Limited A fermentation process for the production of secondary metabolites
KR101723167B1 (en) * 2015-04-28 2017-04-05 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
KR101729251B1 (en) 2015-04-28 2017-04-21 주식회사 대웅 Medium Composition for Preparing Botulinum Toxin
CN105817190B (en) * 2016-03-15 2019-01-08 浙江凯色丽科技发展有限公司 Hydrolyze automatic control system
CN111944734B (en) * 2019-05-17 2023-01-10 中国科学院微生物研究所 Method for improving yield of streptomycete polyketide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
ES444948A1 (en) * 1975-02-07 1977-08-16 Glaxo Lab Ltd Pure potassium salt of clavulanic acid
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use

Also Published As

Publication number Publication date
WO2000001840A1 (en) 2000-01-13
AU5409799A (en) 2000-01-24
EP1097238A1 (en) 2001-05-09
CA2336363A1 (en) 2000-01-13
MXPA00012930A (en) 2002-05-08
CN1308682A (en) 2001-08-15

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