TR199902600T2 - 5-HT4 Reseptör ligandlari olarak 5-aril-3-(8-azabisayklo [3.2.1]okt-3-il)-1,3,4-okzadiazol-2(3h)-on türevleri. - Google Patents
5-HT4 Reseptör ligandlari olarak 5-aril-3-(8-azabisayklo [3.2.1]okt-3-il)-1,3,4-okzadiazol-2(3h)-on türevleri.Info
- Publication number
- TR199902600T2 TR199902600T2 TR1999/02600T TR9902600T TR199902600T2 TR 199902600 T2 TR199902600 T2 TR 199902600T2 TR 1999/02600 T TR1999/02600 T TR 1999/02600T TR 9902600 T TR9902600 T TR 9902600T TR 199902600 T2 TR199902600 T2 TR 199902600T2
- Authority
- TR
- Turkey
- Prior art keywords
- group
- oxadiazol
- azabicyclo
- oct
- aryl
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 1-piperidyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Genel formül (I)'deki bilesik olup, (Formül(I)); içerisinde, R1 bir alkil veya saykloalkilmetil grubunu simgelemekte, X1 bir hidrojen veya halojen atomu ya da bir alkoksi grubunu simgelemekte veya alternatif olarak, OR1 ve X1 birlikte bir -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O- veya -O(CH2)3O- grubunu simgelemekte, X2 bir hidrojen atomu ya da bir amino grubunu simgelemekte, X3 bir hidrojen veya halojen atomunu simgelemekte ve R2 bir hidrojen atomunu, istege bagli olarak substitüsyonu gerçeklestirilen bir alkil grubunu, istege bagli olarak substitüsyonu gerçeklestirilen bir fenilalkil grubunu veya içerisinde n'in 1'den 6'ya kadar bir sayi oldugu ve Z'nin ise bir 1-piperidil grubunu simgeledigi -(CH2)nCO-Z formüllü bir grubu simgelemektedir. Terapötik uygulama.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704802A FR2762316B1 (fr) | 1997-04-18 | 1997-04-18 | Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199902600T2 true TR199902600T2 (tr) | 2000-03-21 |
Family
ID=9506076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02600T TR199902600T2 (tr) | 1997-04-18 | 1998-04-15 | 5-HT4 Reseptör ligandlari olarak 5-aril-3-(8-azabisayklo [3.2.1]okt-3-il)-1,3,4-okzadiazol-2(3h)-on türevleri. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6255319B1 (tr) |
| EP (1) | EP0975631B1 (tr) |
| JP (1) | JP2001521542A (tr) |
| KR (1) | KR20010006452A (tr) |
| CN (1) | CN1260794A (tr) |
| AR (1) | AR012458A1 (tr) |
| AT (1) | ATE206424T1 (tr) |
| AU (1) | AU742666B2 (tr) |
| BG (1) | BG64053B1 (tr) |
| BR (1) | BR9808926A (tr) |
| CA (1) | CA2286106A1 (tr) |
| CO (1) | CO4750656A1 (tr) |
| CZ (1) | CZ289154B6 (tr) |
| DE (1) | DE69801905T2 (tr) |
| DK (1) | DK0975631T3 (tr) |
| EE (1) | EE03769B1 (tr) |
| ES (1) | ES2165162T3 (tr) |
| FR (1) | FR2762316B1 (tr) |
| HU (1) | HUP0002456A3 (tr) |
| IL (1) | IL132352A0 (tr) |
| NO (1) | NO995040L (tr) |
| NZ (1) | NZ500396A (tr) |
| PL (1) | PL186894B1 (tr) |
| PT (1) | PT975631E (tr) |
| RU (1) | RU2186066C2 (tr) |
| SI (1) | SI0975631T1 (tr) |
| SK (1) | SK283441B6 (tr) |
| TR (1) | TR199902600T2 (tr) |
| TW (1) | TW502005B (tr) |
| UA (1) | UA57071C2 (tr) |
| WO (1) | WO1998047898A1 (tr) |
| ZA (1) | ZA983257B (tr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0211230D0 (en) * | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| CN1764458A (zh) * | 2003-03-26 | 2006-04-26 | 麦克公司 | 作为黑皮质素－4受体激动剂的双环哌啶衍生物 |
| US7321042B2 (en) * | 2003-10-16 | 2008-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing N-substituted 3-β-aminonortropanes |
| EP1686965A2 (de) * | 2003-11-18 | 2006-08-09 | Boehringer Ingelheim International GmbH | Feste pharmazeutische zubereitungsform |
| US7737163B2 (en) | 2004-06-15 | 2010-06-15 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| AU2005254800B2 (en) | 2004-06-15 | 2010-12-09 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| FR2873693B1 (fr) * | 2004-07-29 | 2006-09-15 | Sanofi Synthelabo | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
| ES2347265T3 (es) * | 2004-12-22 | 2010-10-27 | Theravance, Inc. | Compuestos de indazol-carboxamida. |
| SE532388C2 (sv) * | 2008-03-14 | 2010-01-12 | Tetra Laval Holdings & Finance | Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning |
| BR112015021559A8 (pt) * | 2013-03-15 | 2019-11-12 | Monsanto Technology Llc | compostos de azóis n-,c-dissubstituídos, composição nematicida aquosa, sementes e métodos para controlar nematódeos indesejados e para controlar ou prevenir uma infestação de nematódeos em um animal". |
| GB201814151D0 (en) | 2018-08-31 | 2018-10-17 | Ucl Business Plc | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055476A (en) * | 1990-08-13 | 1991-10-08 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives |
| DK0604494T3 (da) * | 1991-09-12 | 1999-11-29 | Smithkline Beecham Plc | 5-HT4-receptorantagonister |
| DK0554794T3 (da) * | 1992-02-04 | 1999-04-26 | Eisai Co Ltd | Aminobenzoesyrederivater |
| AU667874B2 (en) * | 1992-02-06 | 1996-04-18 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
| JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
| CZ287268B6 (en) * | 1995-11-09 | 2000-10-11 | Sanofi Synthelabo | Derivatives of 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one, process of their preparation and pharmaceutical preparation in which they are comprised |
-
1997
- 1997-04-18 FR FR9704802A patent/FR2762316B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-15 AT AT98920622T patent/ATE206424T1/de not_active IP Right Cessation
- 1998-04-15 BR BR9808926-9A patent/BR9808926A/pt not_active IP Right Cessation
- 1998-04-15 KR KR1019997009542A patent/KR20010006452A/ko not_active Ceased
- 1998-04-15 CZ CZ19993641A patent/CZ289154B6/cs not_active IP Right Cessation
- 1998-04-15 PL PL98336315A patent/PL186894B1/pl not_active IP Right Cessation
- 1998-04-15 SI SI9830088T patent/SI0975631T1/xx unknown
- 1998-04-15 TR TR1999/02600T patent/TR199902600T2/tr unknown
- 1998-04-15 HU HU0002456A patent/HUP0002456A3/hu unknown
- 1998-04-15 UA UA99105665A patent/UA57071C2/uk unknown
- 1998-04-15 DK DK98920622T patent/DK0975631T3/da active
- 1998-04-15 US US09/403,003 patent/US6255319B1/en not_active Expired - Fee Related
- 1998-04-15 EP EP98920622A patent/EP0975631B1/fr not_active Expired - Lifetime
- 1998-04-15 EE EEP199900487A patent/EE03769B1/xx not_active IP Right Cessation
- 1998-04-15 WO PCT/FR1998/000754 patent/WO1998047898A1/fr not_active Ceased
- 1998-04-15 RU RU99123933/04A patent/RU2186066C2/ru not_active IP Right Cessation
- 1998-04-15 AU AU73415/98A patent/AU742666B2/en not_active Ceased
- 1998-04-15 CA CA002286106A patent/CA2286106A1/en not_active Abandoned
- 1998-04-15 PT PT98920622T patent/PT975631E/pt unknown
- 1998-04-15 DE DE69801905T patent/DE69801905T2/de not_active Expired - Fee Related
- 1998-04-15 SK SK1426-99A patent/SK283441B6/sk unknown
- 1998-04-15 IL IL13235298A patent/IL132352A0/xx unknown
- 1998-04-15 JP JP54514298A patent/JP2001521542A/ja active Pending
- 1998-04-15 NZ NZ500396A patent/NZ500396A/en unknown
- 1998-04-15 ES ES98920622T patent/ES2165162T3/es not_active Expired - Lifetime
- 1998-04-15 CN CN98806195A patent/CN1260794A/zh active Pending
- 1998-04-17 AR ARP980101772A patent/AR012458A1/es not_active Application Discontinuation
- 1998-04-17 TW TW087105892A patent/TW502005B/zh not_active IP Right Cessation
- 1998-04-17 CO CO98021244A patent/CO4750656A1/es unknown
- 1998-04-17 ZA ZA983257A patent/ZA983257B/xx unknown
-
1999
- 1999-10-15 NO NO995040A patent/NO995040L/no not_active Application Discontinuation
- 1999-10-15 BG BG103810A patent/BG64053B1/bg unknown
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