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TR199900310T2 - Trombin inhibitörleri - Google Patents

Trombin inhibitörleri

Info

Publication number
TR199900310T2
TR199900310T2 TR1999/00310T TR9900310T TR199900310T2 TR 199900310 T2 TR199900310 T2 TR 199900310T2 TR 1999/00310 T TR1999/00310 T TR 1999/00310T TR 9900310 T TR9900310 T TR 9900310T TR 199900310 T2 TR199900310 T2 TR 199900310T2
Authority
TR
Turkey
Prior art keywords
thrombin inhibitors
substances
compounds
formula
description
Prior art date
Application number
TR1999/00310T
Other languages
English (en)
Inventor
Baucke Dorit
Lange Udo
Mack Helmut
Seitz Werner
Zierke Thomas
Wolfgang H�Ffken Hans
Hornberger Wilfried
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR199900310T2 publication Critical patent/TR199900310T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Içerisinde A, B, E, ve D' nin tarifte belirtilen anlamlara sahip oldugu formül (I)' in bilesikleri ve de bunlarin üretilmeleri tarif edilmektedir. Maddeler, hastaliklarla mücadele için uygundurlar.
TR1999/00310T 1996-08-14 1997-07-29 Trombin inhibitörleri TR199900310T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632773A DE19632773A1 (de) 1996-08-14 1996-08-14 Neue Thrombininhibitoren

Publications (1)

Publication Number Publication Date
TR199900310T2 true TR199900310T2 (tr) 1999-04-21

Family

ID=7802624

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00310T TR199900310T2 (tr) 1996-08-14 1997-07-29 Trombin inhibitörleri

Country Status (30)

Country Link
US (1) US6114358A (tr)
EP (1) EP0956294B1 (tr)
JP (1) JP4089981B2 (tr)
KR (1) KR20000030002A (tr)
CN (1) CN1228783A (tr)
AR (1) AR009070A1 (tr)
AT (1) ATE268781T1 (tr)
AU (1) AU735364B2 (tr)
BG (1) BG103096A (tr)
BR (1) BR9711191A (tr)
CA (1) CA2263220A1 (tr)
CO (1) CO4900030A1 (tr)
CZ (1) CZ299634B6 (tr)
DE (2) DE19632773A1 (tr)
DK (1) DK0956294T3 (tr)
ES (1) ES2221062T3 (tr)
HR (1) HRP970441B1 (tr)
HU (1) HUP0001826A3 (tr)
ID (1) ID17873A (tr)
IL (1) IL127751A0 (tr)
MY (1) MY132820A (tr)
NO (1) NO990662L (tr)
NZ (1) NZ333679A (tr)
PL (1) PL188411B1 (tr)
PT (1) PT956294E (tr)
RU (1) RU2175328C2 (tr)
SK (1) SK284915B6 (tr)
TR (1) TR199900310T2 (tr)
WO (1) WO1998006741A1 (tr)
ZA (1) ZA977239B (tr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
EP1049673A1 (de) * 1998-01-26 2000-11-08 Basf Aktiengesellschaft Heterocyclische amidine als kallikrein protease inhibitoren
CN1289341A (zh) * 1998-01-26 2001-03-28 Basf公司 凝血酶抑制剂
DE69902754T2 (de) * 1998-02-09 2003-08-07 3-Dimensional Pharmaceuticals, Inc. Heteroaryl-amidinen,-methylamidinen und -guanidinen als protease inhibitoren, insbesondere als urokinase inhibitoren
EP1150979A1 (en) * 1999-02-09 2001-11-07 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
AU4111700A (en) * 1999-04-09 2000-11-14 Basf Aktiengesellschaft Low-molecular inhibitors of complement proteases
EP1169315A2 (de) * 1999-04-09 2002-01-09 Basf Aktiengesellschaft Verfahren zur herstellung von thiophenyl-amidinen
US7144902B1 (en) * 1999-04-09 2006-12-05 Abbott Gmbh & Co. Kg Prodrugs of thrombin inhibitors
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) * 1999-06-18 2001-01-15 성재갑 아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) 1999-07-23 2001-01-25 Basf Ag Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi) 2006-12-04 2012-03-30 Dieffenbacher Panelboard Oy Laitteisto kuitujen, kuten lastujen sirottelemiseksi
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
ES2702182T3 (es) 2013-03-15 2019-02-27 Verseon Corp Compuestos aromáticos multisustituidos como inhibidores de la serina proteasa
HK1214252A1 (zh) 2013-03-15 2016-07-22 Verseon Corporation 作為凝血酶抑制劑的鹵代吡唑
CN103520160B (zh) * 2013-10-17 2015-04-22 广东药学院 三棱中肽类化合物的应用
BR112017004704A2 (pt) 2014-09-17 2018-01-23 Verseon Corp composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo
SG11201706411YA (en) 2015-02-27 2017-09-28 Verseon Corp Substituted pyrazole compounds as serine protease inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4443390A1 (de) * 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
KR100388185B1 (ko) * 1995-02-17 2003-11-28 애보트 게엠베하 운트 콤파니 카게 트롬빈 억제제로서의 신규 디펩티드 아미딘
DE19632772A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren

Also Published As

Publication number Publication date
AU735364B2 (en) 2001-07-05
NO990662D0 (no) 1999-02-12
JP4089981B2 (ja) 2008-05-28
KR20000030002A (ko) 2000-05-25
CZ299634B6 (cs) 2008-10-01
NO990662L (no) 1999-02-12
WO1998006741A1 (de) 1998-02-19
HUP0001826A2 (hu) 2000-09-28
MY132820A (en) 2007-10-31
SK284915B6 (sk) 2006-02-02
RU2175328C2 (ru) 2001-10-27
CO4900030A1 (es) 2000-03-27
CN1228783A (zh) 1999-09-15
BR9711191A (pt) 1999-08-17
EP0956294B1 (de) 2004-06-09
AU3941797A (en) 1998-03-06
CA2263220A1 (en) 1998-02-19
DE59711714D1 (de) 2004-07-15
CZ48699A3 (cs) 1999-05-12
HUP0001826A3 (en) 2002-01-28
PL188411B1 (pl) 2005-01-31
JP2000516598A (ja) 2000-12-12
HRP970441B1 (en) 2005-04-30
PT956294E (pt) 2004-10-29
ZA977239B (en) 1999-02-15
PL331540A1 (en) 1999-07-19
SK899A3 (en) 1999-06-11
ES2221062T3 (es) 2004-12-16
EP0956294A1 (de) 1999-11-17
US6114358A (en) 2000-09-05
DK0956294T3 (da) 2004-10-11
ID17873A (id) 1998-02-05
ATE268781T1 (de) 2004-06-15
BG103096A (en) 1999-09-30
HRP970441A2 (en) 1998-06-30
IL127751A0 (en) 1999-10-28
DE19632773A1 (de) 1998-02-19
NZ333679A (en) 1999-09-29
AR009070A1 (es) 2000-03-08

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