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TR199701645A2 - Vitronektin reseptör antagonistleri,bunlarin imalati ve kullanimi - Google Patents

Vitronektin reseptör antagonistleri,bunlarin imalati ve kullanimi

Info

Publication number
TR199701645A2
TR199701645A2 TR97/01645A TR9701645A TR199701645A2 TR 199701645 A2 TR199701645 A2 TR 199701645A2 TR 97/01645 A TR97/01645 A TR 97/01645A TR 9701645 A TR9701645 A TR 9701645A TR 199701645 A2 TR199701645 A2 TR 199701645A2
Authority
TR
Turkey
Prior art keywords
manufacture
receptor antagonists
vitronectin receptor
compounds according
compounds
Prior art date
Application number
TR97/01645A
Other languages
English (en)
Other versions
TR199701645A3 (tr
Inventor
Wehner Volkmar
Ulrich Stilz Hans
Peyman Anuschirwan
Scheunemann Karlheinz
Ruxer Jean-Marie
Carniato Denis
Lefrancois Jean-Michel
Richard Gadek Thomas
Mcdowell Robert
Original Assignee
Hoechst Aktiengesellschaft
Genentech,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft, Genentech,Inc. filed Critical Hoechst Aktiengesellschaft
Publication of TR199701645A3 publication Critical patent/TR199701645A3/tr
Publication of TR199701645A2 publication Critical patent/TR199701645A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Mevcut bulusun konusu formül I'e göre olan bilesikler, A-B-D-E-F-G (I) ki formülde A, B, D, E, F, ve G istemlerde belirtilen anlamlara sahiptirler, bu bilesiklerin imalati ve bunlarin ilaç maddesi olarak kullanimidir. Bulusa göre olan bilesikler vitronektin reseptör antagonistleri ve kemik resorpsiyonu inhibitörleri olarak kullanilmaktadirlar.
TR97/01645A 1996-12-20 1997-12-18 Vitronektin reseptör antagonistleri,bunlarin imalati ve kullanimi TR199701645A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19653645A DE19653645A1 (de) 1996-12-20 1996-12-20 Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung

Publications (2)

Publication Number Publication Date
TR199701645A3 TR199701645A3 (tr) 1998-07-21
TR199701645A2 true TR199701645A2 (tr) 1998-07-21

Family

ID=7815760

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/01645A TR199701645A2 (tr) 1996-12-20 1997-12-18 Vitronektin reseptör antagonistleri,bunlarin imalati ve kullanimi

Country Status (19)

Country Link
US (1) US5990145A (tr)
EP (1) EP0854145A3 (tr)
JP (1) JPH10182617A (tr)
KR (1) KR19980064419A (tr)
CN (1) CN1200373A (tr)
AR (1) AR010369A1 (tr)
AU (1) AU729760B2 (tr)
BR (1) BR9706386A (tr)
CA (1) CA2225267A1 (tr)
CZ (1) CZ411297A3 (tr)
DE (1) DE19653645A1 (tr)
HU (1) HUP9702509A3 (tr)
ID (1) ID19245A (tr)
IL (1) IL122643A0 (tr)
NO (1) NO975975L (tr)
NZ (1) NZ329429A (tr)
PL (1) PL323968A1 (tr)
TR (1) TR199701645A2 (tr)
ZA (1) ZA9711315B (tr)

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DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
JP2002533404A (ja) 1998-12-23 2002-10-08 ジー・ディー・サール・アンド・カンパニー 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法
US6545032B1 (en) * 1999-09-17 2003-04-08 Torrey Pines Institute For Molecular Studies Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds
DE10028575A1 (de) 2000-06-14 2002-03-14 Basf Ag Integrinliganden
TWI258469B (en) * 2001-03-19 2006-07-21 Dainippon Pharmaceutical Co Aryl-substituted alicyclic compounds and pharmaceutical composition containing the same
AU2002316855B2 (en) 2001-04-24 2008-03-13 Merck Patent Gmbh Combination therapy using anti-angiogenic agents and TNFalpha
KR20040058229A (ko) 2001-10-22 2004-07-03 더 스크립스 리서치 인스티튜트 항체 표적화 화합물
IL161692A0 (en) 2001-11-13 2004-09-27 Dimensional Pharm Inc 14-benzodiazepine derivatives and pharmaceutical compositions containing the same
US7205315B2 (en) * 2003-09-27 2007-04-17 Sanofi-Aventis Deutschland Gmbh Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases
CA2630415A1 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
AR056155A1 (es) * 2005-10-26 2007-09-19 Bristol Myers Squibb Co Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
KR20080089489A (ko) 2006-01-18 2008-10-06 메르크 파텐트 게엠베하 인테그린 리간드를 사용하는 암치료용 특이적 요법
US7553836B2 (en) * 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
US20100069302A1 (en) 2007-07-18 2010-03-18 Stefan Krueger Specific therapy and medicament using integrin ligands for treating cancer
PE20091928A1 (es) * 2008-05-29 2009-12-31 Bristol Myers Squibb Co Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
EP2395992A2 (en) 2009-02-10 2011-12-21 The Scripps Research Institute Chemically programmed vaccination
SG176103A1 (en) 2009-05-25 2011-12-29 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
JP6649902B2 (ja) 2014-05-30 2020-02-19 ファイザー・インク 選択的アンドロゲン受容体モジュレーターとしてのカルボニトリル誘導体
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3497164B2 (ja) * 1991-06-28 2004-02-16 スミスクライン・ビーチャム・コーポレイション 二環式フィブリノーゲン拮抗薬
US5217994A (en) * 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
US5204350A (en) * 1991-08-09 1993-04-20 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5786373A (en) * 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2150550A1 (en) * 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
ATE236882T1 (de) * 1992-12-21 2003-04-15 Smithkline Beecham Corp Bicyklische fibrinogen antagoniste
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ES2186720T3 (es) * 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.
BR9508178A (pt) * 1994-06-29 1997-11-18 Smithkline Beecham Corp Antagonistas de receptor de vitronectina
JPH10504807A (ja) * 1994-06-29 1998-05-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗剤
WO1996026190A1 (en) * 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
DE19516483A1 (de) * 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
SI0910563T1 (en) * 1995-06-29 2003-10-31 Smithkline Beecham Corporation Integrin receptor antagonists
CZ203798A3 (cs) * 1995-12-29 1998-12-16 Smithkline Beecham Corporation Antagonista vitronektinového receptoru, farmaceutický přípravek s jeho obsahem, způsob a použití
AU1295597A (en) * 1995-12-29 1997-07-28 Smithkline Beecham Corporation Vitronectin receptor antagonists
AU1354097A (en) * 1995-12-29 1997-07-28 Smithkline Beecham Corporation Vitronectin receptor antagonists
DK0796855T3 (da) * 1996-03-20 2002-05-27 Hoechst Ag Hæmmere af knogleresorption og vitronectin-receptorantagonister
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

Also Published As

Publication number Publication date
DE19653645A1 (de) 1998-06-25
ID19245A (id) 1998-06-28
HU9702509D0 (en) 1998-03-02
ZA9711315B (en) 1998-06-22
NO975975D0 (no) 1997-12-19
CZ411297A3 (cs) 1998-07-15
CN1200373A (zh) 1998-12-02
EP0854145A2 (de) 1998-07-22
TR199701645A3 (tr) 1998-07-21
EP0854145A3 (de) 2000-03-22
KR19980064419A (ko) 1998-10-07
HUP9702509A2 (hu) 1999-06-28
NO975975L (no) 1998-06-22
AU4846497A (en) 1998-06-25
JPH10182617A (ja) 1998-07-07
NZ329429A (en) 1999-05-28
BR9706386A (pt) 2003-04-22
AU729760B2 (en) 2001-02-08
HUP9702509A3 (en) 2001-04-28
IL122643A0 (en) 1998-08-16
AR010369A1 (es) 2000-06-07
CA2225267A1 (en) 1998-06-20
US5990145A (en) 1999-11-23
PL323968A1 (en) 1998-06-22
MX9710389A (es) 1998-08-30

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