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TR199601082A2 - Entegrin receptor antagonists. - Google Patents

Entegrin receptor antagonists.

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Publication number
TR199601082A2
TR199601082A2 TR96/01082A TR9601082A TR199601082A2 TR 199601082 A2 TR199601082 A2 TR 199601082A2 TR 96/01082 A TR96/01082 A TR 96/01082A TR 9601082 A TR9601082 A TR 9601082A TR 199601082 A2 TR199601082 A2 TR 199601082A2
Authority
TR
Turkey
Prior art keywords
alkyl
cycloalkyl
receptor antagonists
entegrin
co2r
Prior art date
Application number
TR96/01082A
Other languages
Turkish (tr)
Other versions
TR199601082A3 (en
Inventor
E. Bondinell William
H. Miller William
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to TR96/01082A priority Critical patent/TR199601082A3/en
Publication of TR199601082A2 publication Critical patent/TR199601082A2/en
Publication of TR199601082A3 publication Critical patent/TR199601082A3/en

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Abstract

This invention relates to formula compounds integrated receptor antagonists wherein A1'is C or N (X1-X2' is CHR1-CH, CR1=CH, NR1-CH, (S(O)-CH or O-CH; X3 is CR5R5, NR5, S(O) or O; R1 is H, C1-6 alkyl, C3-7 cycloalkyl-C0-4 alkyl or Ar-C0-4 alkyl; R'' is R', -C(O)R' or -C(O)OR5, R''' is C1-6 alkyl, C3-7 cycloalkyl-C0-4 alkyl or Ar-C0-4 alkyl; R' is H, C1-6 alkyl, C3-7 cycloalkyl-C0-4 alkyl or Ar-C0-4 alkyl; R2 is -OR',-NR'R'', -NR'SO2-R'''-NR'OR',-OCR2C(O)OR',-OCR2OC(O)-R', -OCR'2C(O)NR'2CF3 or- COCR'2R2; R2 is -OR', CN, -S (O)r R', S(O)2-C(O)R' C(O)NR'2 or CO2R', R5 is independently H1 C1-6 alkyl, C3-7 cycloalkyl-C0-4 alkyl or Ar-C0-4 alkyl; R6 is W-(CR'2)q-Z-(CR'R10)r-U-(CR'2)s-V or W'-(CR'2)q-U-(CR'2)s-; R3, R4 and R7 are independently H, halo, -OR12, -SR12-CN, NR'R12-NO2-CF3CF3S(O9R-, CO2R'-CONR'2, R14-C0-6 alkyl R14-C1-6 oxyalkyl-R14-C2-6 alkaline-R14-C2-6 alkenyl-R14-C0-6 alkyl oxy R14-C0-6 alkyl amino or R14-C0-6 alkyl-S(O)r-; R8'R', C(O)R'; CN, NO2R' or C(O)OR5.
TR96/01082A 1996-12-30 1996-12-30 Entegrin receptor antagonists. TR199601082A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TR96/01082A TR199601082A3 (en) 1996-12-30 1996-12-30 Entegrin receptor antagonists.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR96/01082A TR199601082A3 (en) 1996-12-30 1996-12-30 Entegrin receptor antagonists.

Publications (2)

Publication Number Publication Date
TR199601082A2 true TR199601082A2 (en) 1999-10-21
TR199601082A3 TR199601082A3 (en) 1999-10-21

Family

ID=21621016

Family Applications (1)

Application Number Title Priority Date Filing Date
TR96/01082A TR199601082A3 (en) 1996-12-30 1996-12-30 Entegrin receptor antagonists.

Country Status (1)

Country Link
TR (1) TR199601082A3 (en)

Also Published As

Publication number Publication date
TR199601082A3 (en) 1999-10-21

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