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TNSN06129A1 - Derives de pyrazolyle et d'imidazolyle bicycliques et leurs utilisations - Google Patents

Derives de pyrazolyle et d'imidazolyle bicycliques et leurs utilisations

Info

Publication number
TNSN06129A1
TNSN06129A1 TNP2006000129A TNSN06129A TNSN06129A1 TN SN06129 A1 TNSN06129 A1 TN SN06129A1 TN P2006000129 A TNP2006000129 A TN P2006000129A TN SN06129 A TNSN06129 A TN SN06129A TN SN06129 A1 TNSN06129 A1 TN SN06129A1
Authority
TN
Tunisia
Prior art keywords
des
sont
cannabinoides
imidazolyl derivatives
composés
Prior art date
Application number
TNP2006000129A
Other languages
English (en)
Inventor
Robert Lee Dow
David Andrew Griffith
Philip Albert Carpino
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN06129A1 publication Critical patent/TNSN06129A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Des composés de formule (I) sont décrits dans le présent mémoire. Les composés se sont révélés jouer le rôle de ligands des récepteurs de cannabinoides et sont donc utiles dans le traitement de maladies liées à la médiation des récepteurs de cannabinoides chez des animaux.
TNP2006000129A 2003-11-07 2006-05-05 Derives de pyrazolyle et d'imidazolyle bicycliques et leurs utilisations TNSN06129A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51828003P 2003-11-07 2003-11-07
PCT/IB2004/003522 WO2005044822A1 (fr) 2003-11-07 2004-10-25 Composes bicycliques pyrazolyliques et imidazolyliques et leurs utilisations

Publications (1)

Publication Number Publication Date
TNSN06129A1 true TNSN06129A1 (fr) 2007-11-15

Family

ID=34572986

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000129A TNSN06129A1 (fr) 2003-11-07 2006-05-05 Derives de pyrazolyle et d'imidazolyle bicycliques et leurs utilisations

Country Status (29)

Country Link
US (2) US7151097B2 (fr)
EP (1) EP1682554A1 (fr)
JP (2) JP4056549B2 (fr)
KR (1) KR20060086396A (fr)
CN (1) CN1886407A (fr)
AP (1) AP2006003601A0 (fr)
AR (1) AR046831A1 (fr)
AU (1) AU2004286909A1 (fr)
BR (1) BRPI0416299A (fr)
CA (1) CA2544752A1 (fr)
CR (1) CR8387A (fr)
DO (1) DOP2004001024A (fr)
EA (1) EA009742B1 (fr)
EC (1) ECSP066549A (fr)
GT (1) GT200400226A (fr)
HR (1) HRP20060166A2 (fr)
IL (1) IL175283A0 (fr)
IS (1) IS8426A (fr)
MA (1) MA28151A1 (fr)
MX (1) MXPA06005023A (fr)
NL (1) NL1027434C2 (fr)
NO (1) NO20062618L (fr)
OA (1) OA13280A (fr)
PA (1) PA8616801A1 (fr)
PE (1) PE20050576A1 (fr)
TN (1) TNSN06129A1 (fr)
TW (2) TWI280245B (fr)
WO (1) WO2005044822A1 (fr)
ZA (1) ZA200603594B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10138275A1 (de) * 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Verbindungen zur Beseitigung der Anhedonie
US7094572B2 (en) * 2003-03-14 2006-08-22 Bristol-Myers Squibb Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
US7151097B2 (en) * 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
ITMI20041032A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Compositi farmaceutici
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060025448A1 (en) 2004-07-22 2006-02-02 Cadila Healthcare Limited Hair growth stimulators
EP1797041A2 (fr) * 2004-09-27 2007-06-20 Pfizer Products Inc. Procede permettant de preparer des composes de pyrazolyle bicycliques
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
WO2006111849A1 (fr) * 2005-04-20 2006-10-26 Pfizer Products Inc. Composes heteromatiques acylaminobicycliques tenant lieu de ligands du recepteur cannabinoide
WO2006129193A2 (fr) * 2005-05-27 2006-12-07 Pfizer Products Inc. Polytherapie pour le traitement de l'obesite ou le maintien du poids apres une perte ponderale
US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
EP1951678A1 (fr) 2005-10-21 2008-08-06 Mitsubishi Tanabe Pharma Corporation Composes pyrazole presentant une activite antagoniste du recepteur cannabinoide (cb1)
WO2007060525A2 (fr) 2005-11-28 2007-05-31 Pfizer Products Inc. Procédé de synthèse de composés bicycliques de type pyrazolyle et imidazolyle
US8138188B2 (en) * 2006-02-23 2012-03-20 Pfizer Inc. Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
EP2018863B9 (fr) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
WO2008048648A2 (fr) * 2006-10-17 2008-04-24 Acadia Pharmaceuticals Inc. Composés modulant cb1 et utilisation de ces derniers
JP2010509392A (ja) 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
WO2009032754A2 (fr) * 2007-08-31 2009-03-12 Kalypsys, Inc. Modulateurs des récepteurs cannabinoïdes à base d' hétérocyclodiazépine pour traiter une maladie
EP2116618A1 (fr) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnostic et traitement de la maladie de Kawasaki
AU2009278838B2 (en) * 2008-08-06 2013-07-25 Pfizer Limited Diazepine and diazocane compounds as MC4 agonists
US9549006B2 (en) * 2013-07-31 2017-01-17 Cisco Technology, Inc. Self-adaptive sample period for content sharing in communication sessions
US9321755B2 (en) * 2013-11-08 2016-04-26 Incyte Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US11504416B2 (en) 2018-09-04 2022-11-22 Paw Power, Inc. Formulation with cannabinoids
US11191814B2 (en) 2018-09-04 2021-12-07 Paw Power, Inc. Pet food formulation with cannabinoids
US12302903B2 (en) * 2019-08-09 2025-05-20 Nihon Nohyaku Co., Ltd. Oxazepinone derivative, agricultural/horticultural insecticide containing the same, and method for using the same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058869A2 (fr) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Modulateurs de recepteurs aux cannabinoides, leurs procedes de preparation et utilisations de modulateurs de recepteurs aux cannabinoides pour le traitement de maladies respiratoires et non respiratoires
CA2457922A1 (fr) 2001-08-31 2003-03-13 University Of Connecticut Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides
JP2005504100A (ja) 2001-09-24 2005-02-10 バイエル・フアーマシユーチカルズ・コーポレーシヨン 肥満の治療のための１，５，６，７−テトラヒドロピロロ［３，２−ｃ］ピリジン誘導体の製造法および使用
GB0207249D0 (en) 2002-03-27 2002-05-08 Glaxo Group Ltd Novel compounds
EP1556373A1 (fr) 2002-10-18 2005-07-27 Pfizer Products Inc. Ligands des recepteurs des cannabinoides et applications de ceux-ci
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
US7247628B2 (en) 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7268133B2 (en) 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
US20040214856A1 (en) 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US7423031B2 (en) 2003-05-01 2008-09-09 Irm Llc Compounds and compositions as protein kinase inhibitors
BRPI0410289A (pt) 2003-05-07 2006-05-16 Pfizer Prod Inc ligantes do receptor de canabinóides e suas utilizações
US7232823B2 (en) 2003-06-09 2007-06-19 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
US20040259887A1 (en) 2003-06-18 2004-12-23 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US20050026983A1 (en) 2003-07-30 2005-02-03 Pfizer Inc Imidazole compounds and uses thereof
US7151097B2 (en) * 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
EP1797041A2 (fr) * 2004-09-27 2007-06-20 Pfizer Products Inc. Procede permettant de preparer des composes de pyrazolyle bicycliques

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EP1682554A1 (fr) 2006-07-26
EA009742B1 (ru) 2008-04-28
GT200400226A (es) 2005-09-06
JP4056549B2 (ja) 2008-03-05
IS8426A (is) 2006-04-21
CA2544752A1 (fr) 2005-05-19
AR046831A1 (es) 2005-12-28
HRP20060166A2 (en) 2006-10-31
IL175283A0 (en) 2006-09-05
JP2007302685A (ja) 2007-11-22
CN1886407A (zh) 2006-12-27
TW200716135A (en) 2007-05-01
WO2005044822A1 (fr) 2005-05-19
BRPI0416299A (pt) 2007-01-23
AU2004286909A1 (en) 2005-05-19
KR20060086396A (ko) 2006-07-31
PE20050576A1 (es) 2005-09-14
MA28151A1 (fr) 2006-09-01
JP2007510707A (ja) 2007-04-26
MXPA06005023A (es) 2006-07-06
DOP2004001024A (es) 2005-05-14
US20050101592A1 (en) 2005-05-12
NO20062618L (no) 2006-08-07
CR8387A (es) 2007-05-30
OA13280A (en) 2007-01-31
ECSP066549A (es) 2006-10-17
TW200526669A (en) 2005-08-16
PA8616801A1 (es) 2006-05-16
TWI280245B (en) 2007-05-01
EA200600647A1 (ru) 2006-10-27
AP2006003601A0 (en) 2006-04-30
ZA200603594B (en) 2007-09-26
US7151097B2 (en) 2006-12-19
US20070027133A1 (en) 2007-02-01
NL1027434C2 (nl) 2007-11-27
NL1027434A1 (nl) 2005-05-10

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