TNSN05307A1 - 5-membered heterocycle-based p38 kinase inhibitors - Google Patents
5-membered heterocycle-based p38 kinase inhibitorsInfo
- Publication number
- TNSN05307A1 TNSN05307A1 TNP2005000307A TNSN05307A TNSN05307A1 TN SN05307 A1 TNSN05307 A1 TN SN05307A1 TN P2005000307 A TNP2005000307 A TN P2005000307A TN SN05307 A TNSN05307 A TN SN05307A TN SN05307 A1 TNSN05307 A1 TN SN05307A1
- Authority
- TN
- Tunisia
- Prior art keywords
- membered heterocycle
- kinase
- kinase inhibitors
- inhibitors
- disorders
- Prior art date
Links
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38 alpha and p38 beta kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including method of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48342803P | 2003-06-26 | 2003-06-26 | |
| PCT/US2004/020384 WO2005009973A1 (en) | 2003-06-26 | 2004-06-24 | 5-membered heterocycle-based p38 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN05307A1 true TNSN05307A1 (en) | 2007-07-10 |
Family
ID=36994641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2005000307A TNSN05307A1 (en) | 2003-06-26 | 2005-11-30 | 5-membered heterocycle-based p38 kinase inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES2369541T3 (en) |
| TN (1) | TNSN05307A1 (en) |
| ZA (1) | ZA200509018B (en) |
-
2004
- 2004-06-24 ES ES04777075T patent/ES2369541T3/en not_active Expired - Lifetime
-
2005
- 2005-11-08 ZA ZA200509018A patent/ZA200509018B/en unknown
- 2005-11-30 TN TNP2005000307A patent/TNSN05307A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2369541T3 (en) | 2011-12-01 |
| ZA200509018B (en) | 2007-03-28 |
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