TNSN05082A1 - PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF) - Google Patents
PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF)Info
- Publication number
- TNSN05082A1 TNSN05082A1 TNP2005000082A TNSN05082A TNSN05082A1 TN SN05082 A1 TNSN05082 A1 TN SN05082A1 TN P2005000082 A TNP2005000082 A TN P2005000082A TN SN05082 A TNSN05082 A TN SN05082A TN SN05082 A1 TNSN05082 A1 TN SN05082A1
- Authority
- TN
- Tunisia
- Prior art keywords
- tgf
- growth factor
- transforming growth
- pyrazole derivatives
- inhibitors
- Prior art date
Links
- 102000009618 Transforming Growth Factors Human genes 0.000 title abstract 5
- 108010009583 Transforming Growth Factors Proteins 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Des dérivés de pyrazole nouveaux de formule (Ia), Des intermédiaires pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")- beta . Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF, comprenant, par exemple, le cancer et des maladies fibrotiques.Novel pyrazole derivatives of formula (Ia), intermediates for their preparation, pharmaceutical compositions containing them and their use in medicine are described. The compounds of the present invention are potent inhibitors of the transforming growth factor ("TGF") - beta signaling pathway. They are useful in the treatment of various disease states related to TGF, including, for example, cancer and fibrotic diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41214602P | 2002-09-18 | 2002-09-18 | |
| PCT/IB2003/003933 WO2004026306A2 (en) | 2002-09-18 | 2003-09-08 | Pyrazole derivatives as transforming growth factor (tgf) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN05082A1 true TNSN05082A1 (en) | 2007-05-14 |
Family
ID=47043989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2005000082A TNSN05082A1 (en) | 2002-09-18 | 2005-03-18 | PYRAZOLE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR (TGF) |
Country Status (2)
| Country | Link |
|---|---|
| GT (1) | GT200300203A (en) |
| TN (1) | TNSN05082A1 (en) |
-
2003
- 2003-09-17 GT GT200300203A patent/GT200300203A/en unknown
-
2005
- 2005-03-18 TN TNP2005000082A patent/TNSN05082A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200300203A (en) | 2004-06-23 |
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