TNSN04250A1 - Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof. - Google Patents
Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof.Info
- Publication number
- TNSN04250A1 TNSN04250A1 TNP2004000250A TNSN04250A TNSN04250A1 TN SN04250 A1 TNSN04250 A1 TN SN04250A1 TN P2004000250 A TNP2004000250 A TN P2004000250A TN SN04250 A TNSN04250 A TN SN04250A TN SN04250 A1 TNSN04250 A1 TN SN04250A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compounds
- production
- acidic groups
- medicaments containing
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- VDOXIAUNJCHYRC-UHFFFAOYSA-N 1,3-diphenylazetidin-2-one Chemical group O=C1C(C=2C=CC=CC=2)CN1C1=CC=CC=C1 VDOXIAUNJCHYRC-UHFFFAOYSA-N 0.000 title 1
- 230000002378 acidificating effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to compounds of formula (I); in which R1; R2; R3; R4; R5 and R6 are defined as cited; in addition to their physiologically compatible salts. The compounds are suitable for use e.g. as hypolipidaemics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10227508A DE10227508A1 (en) | 2002-06-19 | 2002-06-19 | Acid group-substituted diphenylazetidinones, processes for their preparation, pharmaceutical compositions containing them and their use |
| PCT/EP2003/005816 WO2004000805A1 (en) | 2002-06-19 | 2003-06-04 | Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN04250A1 true TNSN04250A1 (en) | 2007-03-12 |
Family
ID=29719283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2004000250A TNSN04250A1 (en) | 2002-06-19 | 2004-12-16 | Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof. |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1517891B1 (en) |
| JP (1) | JP2005533073A (en) |
| KR (1) | KR20050008835A (en) |
| CN (1) | CN100467448C (en) |
| AR (1) | AR039690A1 (en) |
| AU (1) | AU2003238210B2 (en) |
| BR (1) | BR0311896A (en) |
| CA (1) | CA2490112A1 (en) |
| DE (1) | DE10227508A1 (en) |
| EC (1) | ECSP045497A (en) |
| HN (1) | HN2003000185A (en) |
| HR (1) | HRPK20041201B3 (en) |
| IL (1) | IL165789A0 (en) |
| MA (1) | MA27206A1 (en) |
| MX (1) | MXPA04012093A (en) |
| NO (1) | NO20050134L (en) |
| OA (1) | OA12869A (en) |
| PA (1) | PA8576101A1 (en) |
| PE (1) | PE20040564A1 (en) |
| PL (1) | PL372700A1 (en) |
| RS (1) | RS108404A (en) |
| RU (1) | RU2287522C2 (en) |
| SV (1) | SV2004001548A (en) |
| TN (1) | TNSN04250A1 (en) |
| TW (1) | TW200413311A (en) |
| UA (1) | UA78577C2 (en) |
| UY (1) | UY27853A1 (en) |
| WO (1) | WO2004000805A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| ATE485267T1 (en) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT |
| WO2006060461A1 (en) | 2004-12-03 | 2006-06-08 | Schering Corporation | Substituted piperazines as cb1 antagonists |
| EP1865947A1 (en) | 2005-04-04 | 2007-12-19 | Pontificia Universidad Catolica de Chile | The use of ezetimibe in the prevention and treatment of cholesterol gallstones |
| ATE450526T1 (en) | 2005-06-20 | 2009-12-15 | Schering Corp | PIPERIDINE DERIVATIVES SUITABLE AS ANTAGONISTS OF HISTAMINE H3 |
| SA06270191B1 (en) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| US8829041B2 (en) * | 2006-06-23 | 2014-09-09 | Abbvie Inc. | Cyclopropyl amine derivatives |
| EP2061767B1 (en) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| DE102007002260A1 (en) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome |
| EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
| CN101200443B (en) * | 2007-10-17 | 2011-06-29 | 中国药科大学 | Azetidinone derivatives, processes for their preparation and pharmaceutical combinations containing them |
| DE102007054497B3 (en) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Novel crystalline diphenylazetidinone hydrates and process for their preparation |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (en) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | Azetidinone compound and medical applications thereof |
| CN102482312A (en) | 2009-08-26 | 2012-05-30 | 赛诺菲 | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2582709B1 (en) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120053A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (en) | 2011-03-08 | 2015-04-22 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| WO2012120056A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3300B (en) * | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| RU2181297C2 (en) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Method of treatment of pathological syndrome and medicinal agent |
| DE10042447A1 (en) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Vertebrate intestinal protein that absorbs cholesterol and use of this protein to identify inhibitors of intestinal cholesterol transport |
| ES2277890T3 (en) * | 2000-12-21 | 2007-08-01 | Sanofi-Aventis Deutschland Gmbh | NEW DIFENILAZETIDINONES, PROCEDURE FOR THE PREPARATION, MEDICATIONS CONTAINING THESE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF LIPID METABOLISM DISORDERS. |
| IL156552A0 (en) * | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| HUP0401073A2 (en) * | 2000-12-21 | 2004-09-28 | Aventis Pharma Deutschland Gmbh. | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
-
2002
- 2002-06-19 DE DE10227508A patent/DE10227508A1/en not_active Withdrawn
-
2003
- 2003-04-06 UA UAA200500488A patent/UA78577C2/en unknown
- 2003-06-02 SV SV2003001548A patent/SV2004001548A/en not_active Application Discontinuation
- 2003-06-04 AU AU2003238210A patent/AU2003238210B2/en not_active Ceased
- 2003-06-04 CN CNB038143321A patent/CN100467448C/en not_active Expired - Fee Related
- 2003-06-04 KR KR10-2004-7020643A patent/KR20050008835A/en not_active Ceased
- 2003-06-04 RS YUP-1084/04A patent/RS108404A/en unknown
- 2003-06-04 JP JP2004514661A patent/JP2005533073A/en not_active Abandoned
- 2003-06-04 EP EP03735535A patent/EP1517891B1/en not_active Expired - Lifetime
- 2003-06-04 HR HR20041201A patent/HRPK20041201B3/en not_active IP Right Cessation
- 2003-06-04 BR BR0311896-7A patent/BR0311896A/en not_active IP Right Cessation
- 2003-06-04 MX MXPA04012093A patent/MXPA04012093A/en active IP Right Grant
- 2003-06-04 CA CA002490112A patent/CA2490112A1/en not_active Abandoned
- 2003-06-04 OA OA1200400331A patent/OA12869A/en unknown
- 2003-06-04 RU RU2005101093/04A patent/RU2287522C2/en not_active IP Right Cessation
- 2003-06-04 WO PCT/EP2003/005816 patent/WO2004000805A1/en not_active Ceased
- 2003-06-04 PL PL03372700A patent/PL372700A1/en not_active Application Discontinuation
- 2003-06-16 UY UY27853A patent/UY27853A1/en unknown
- 2003-06-16 PE PE2003000596A patent/PE20040564A1/en not_active Application Discontinuation
- 2003-06-17 HN HN2003000185A patent/HN2003000185A/en unknown
- 2003-06-17 TW TW092116321A patent/TW200413311A/en unknown
- 2003-06-17 AR ARP030102144A patent/AR039690A1/en unknown
- 2003-06-18 PA PA20038576101A patent/PA8576101A1/en unknown
-
2004
- 2004-11-16 MA MA27954A patent/MA27206A1/en unknown
- 2004-12-15 IL IL16578904A patent/IL165789A0/en unknown
- 2004-12-16 TN TNP2004000250A patent/TNSN04250A1/en unknown
- 2004-12-16 EC EC2004005497A patent/ECSP045497A/en unknown
-
2005
- 2005-01-11 NO NO20050134A patent/NO20050134L/en not_active Application Discontinuation
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