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TNSN99210A1 - IDENTIFICATION OF SEN VIRUS GENOTYPES - Google Patents

IDENTIFICATION OF SEN VIRUS GENOTYPES

Info

Publication number
TNSN99210A1
TNSN99210A1 TNTNSN99210A TNSN99210A TNSN99210A1 TN SN99210 A1 TNSN99210 A1 TN SN99210A1 TN TNSN99210 A TNTNSN99210 A TN TNSN99210A TN SN99210 A TNSN99210 A TN SN99210A TN SN99210 A1 TNSN99210 A1 TN SN99210A1
Authority
TN
Tunisia
Prior art keywords
acid molecule
nucleic acid
virus
genome
relates
Prior art date
Application number
TNTNSN99210A
Other languages
French (fr)
Inventor
Daniele Primi
Gianfranco Fiordalisi
Giovanni Lorenzo Mantero
Sonia Mattioli
Alessandra Sottini
Fabrizio Bonelli
Laura Vaglini
Paolo Olivero
Corso Andrea Dal
Marco Bonelli
Original Assignee
Diasorin S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI982437 external-priority patent/IT1303732B1/en
Priority claimed from ITMI990923 external-priority patent/IT1312552B1/en
Application filed by Diasorin S R L filed Critical Diasorin S R L
Publication of TNSN99210A1 publication Critical patent/TNSN99210A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13Tumour cells, irrespective of tissue of origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/00021Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/00022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENTION SE RAPPORTE A UNE MOLECULE D'ACIDE NUCLEIQUE REPRESENTANT LE GENOME D'UN AGENT VIRAL/VIRUS, LADITE MOLECULE D'ACIDE NUCLEIQUE AYANT, AU MOINS, UNE DES CARACTERISTIQUES SUIVANTES : (a) ELLE CONTIENT, AU MOINS, UN CADRE DE LECTURE OUVERT (ORF) QUI ENCODE UN POLYPEPTIDE AYANT UNE SEQUENCE D'ACIDE AMINE DIVULGUEE DANS CE DOCUMENT, (b) ELLE COMPREND UNE SEQUENCE ADN COMME DECRIT DANS CE DOCUMENT, (c) ELLE S'HYBRIDE, DE PREFERENCE, DANS DES CONDITIONS ASTRINGENTES EN UN BRIN COMPLEMENTAIRE DE LA MOLECULE D'ACIDE NUCLEAIRE DECRITE ICI, MAIS PAS EN UN BRIN COMPLEMENTAIRE DU GENOME DU VIRUS TT ; (d) ELLE EST DEGENEREE PAR RAPPORT A LA MOLECULE D'ACIDE NUCLEIQUE HYBRIDANTE, (e) ELLE EST IDENTIQUE A, AU MOINS, 60% A LA MOLECULE D'ACIDE NUCLEIQUE REPRESENTANT LE GENOME DE L'AGENT VIRAL/VIRUS DE L'INVENTION ; ET (f) DES PARTIES DE CETTE MOLECULE PEUVENT ETRE AMPLIFIEES DANS DES CONDITIONS APPROPRIEES PAR PCR UTILISANT DES CATALYSEURS COMME DEFINI ICI. L'INVENTION SE RAPPORTE A DES VECTEURS COMPRENANT LADITE MOLECULE D'ACIDE NUCLEIQUE, DES METHODES DE PRODUCTION DE (POLY)PEPTIDE(S) ENCODES PAR LADITE MOLECULE D'ACIDE NUCLEIQUE ET ANTICORPS AUX DITS POLY(PEPTIDES)s ET/OU LESDITS AGENTS VIRUS/VIRAUX. EN PLUS, L'INVENTION SE RAPPORTE A DES COMPOSITIONS, DE PREFERENCE, DES COMPOSITIONS PHARMACEUTIQUES, DES VACCINS, DES DIAGNOSTICS ET KITS DE DIAGNOSTIC COMPRENANT OU UTILISANT DES COMPOSES DE L'INVENTION.THE PRESENT INVENTION RELATES TO A NUCLEIC ACID MOLECULE REPRESENTING THE GENOME OF A VIRAL AGENT / VIRUS, SAID NUCLEIC ACID MOLECULE HAVING AT LEAST ONE OF THE FOLLOWING CHARACTERISTICS: (a) IT CONTAINS AT LEAST ONE FRAME OPEN READER (ORF) THAT ENCODES A POLYPEPTIDE HAVING AN AMINO ACID SEQUENCE DISCLOSED IN THIS DOCUMENT, (b) IT INCLUDES A DNA SEQUENCE AS DESCRIBED IN THIS DOCUMENT, (c) IT HYBRIDIZES, PREFERABLY, UNDER CONDITIONS ASTRINGENTS IN A COMPLEMENTARY STRAND OF THE NUCLEAR ACID MOLECULE DESCRIBED HERE, BUT NOT IN A COMPLEMENTARY STRAND OF THE GENOME OF TT VIRUS; (d) IT IS DEGENERATED IN RELATION TO THE HYBRIDANT NUCLEIC ACID MOLECULE, (e) IT IS IDENTICAL TO AT LEAST 60% TO THE NUCLEIC ACID MOLECULE REPRESENTING THE VIRAL AGENT / VIRUS GENOME INVENTION; AND (f) PARTS OF THIS MOLECULE MAY BE AMPLIFIED UNDER APPROPRIATE CONDITIONS BY PCR USING CATALYSTS AS DEFINED HERE. THE INVENTION RELATES TO VECTORS COMPRISING SAID NUCLEIC ACID MOLECULE, METHODS OF PRODUCING (POLY) PEPTIDE (S) ENCODED BY SAID NUCLEIC ACID MOLECULE AND ANTIBODIES TO SAID POLY (PEPTIDES) s AND / OR SUCH AGENTS VIRUS / VIRAL. IN ADDITION, THE INVENTION RELATES TO COMPOSITIONS, PREFERABLY, PHARMACEUTICAL COMPOSITIONS, VACCINES, DIAGNOSTICS AND DIAGNOSTIC KITS COMPRISING OR USING COMPOUNDS OF THE INVENTION.

TNTNSN99210A 1998-11-10 1999-11-08 IDENTIFICATION OF SEN VIRUS GENOTYPES TNSN99210A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI982437 IT1303732B1 (en) 1998-11-10 1998-11-10 Nucleic acids representing the genome of the SEN virus (SENV) and encoded proteins, useful for treatment of hepatopathies, inflammatory diseases and proliferative disorders such as cancer
ITMI990923 IT1312552B1 (en) 1999-04-30 1999-04-30 Nucleic acids representing the genome of the SEN virus (SENV) and encoded proteins, useful for treatment of hepatopathies, inflammatory diseases and proliferative disorders such as cancer
EP99830298 1999-05-14
EP99113932 1999-07-16

Publications (1)

Publication Number Publication Date
TNSN99210A1 true TNSN99210A1 (en) 2005-11-10

Family

ID=27443821

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99210A TNSN99210A1 (en) 1998-11-10 1999-11-08 IDENTIFICATION OF SEN VIRUS GENOTYPES

Country Status (8)

Country Link
EP (1) EP1137779A2 (en)
JP (1) JP2002529092A (en)
AR (1) AR021143A1 (en)
AU (1) AU1381600A (en)
NO (1) NO20012276L (en)
PE (1) PE20001331A1 (en)
TN (1) TNSN99210A1 (en)
WO (1) WO2000028039A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2212901A (en) * 1999-12-10 2001-06-18 Roche Diagnostics Gmbh Hepatitis virus sentinel virus i (svi)
DE10007234A1 (en) * 2000-02-17 2001-10-18 Sension Biolog Detektions Und Peptide and nucleic acid coding therefor for the determination, diagnosis and therapy of diseases of the nervous system
DE10144346A1 (en) * 2001-09-10 2003-04-03 Deutsches Krebsforsch TT virus sequences in human tumor tissues, means for their detection and tumor therapy
DK2399928T3 (en) * 2010-06-23 2018-01-29 Deutsches Krebsforsch Specific TT virus sequences and chimeric TT virus host cell DNA molecules for use in the diagnosis, prevention and treatment of cancer and autoimmunity
US20110318363A1 (en) 2010-06-23 2011-12-29 Deutsches Krebsforschungszentrum Specific TT virus sequences and chimeric TT virus host cell DNA molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity
DK2585477T3 (en) * 2010-06-23 2018-09-03 Deutsches Krebsforsch RELEASED TT VIRUS MOLECULES FOR USE FOR DIAGNOSTICATION, PREVENTION AND TREATMENT OF CANCER AND AUTO-IMMUNITY
US9676828B2 (en) 2010-06-23 2017-06-13 Deutsches Krebsforschungszentrum Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU741656B2 (en) * 1997-07-25 2001-12-06 Tamura, Ryoji Non-B non-C non-G hepatitis virus gene, polynucleotide, polypeptide, virion, method for separating virion, and method for detecting virus
AU4259299A (en) * 1998-05-13 1999-11-29 Innogenetics N.V. New sequences of tt viruses for use in diagnosis, prevention and treatment of ttv infections

Also Published As

Publication number Publication date
EP1137779A2 (en) 2001-10-04
NO20012276D0 (en) 2001-05-09
PE20001331A1 (en) 2000-12-19
NO20012276L (en) 2001-07-09
JP2002529092A (en) 2002-09-10
AU1381600A (en) 2000-05-29
AR021143A1 (en) 2002-06-12
WO2000028039A2 (en) 2000-05-18
WO2000028039A3 (en) 2000-10-05

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