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TNSN97070A1 - Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant - Google Patents

Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant

Info

Publication number
TNSN97070A1
TNSN97070A1 TNTNSN97070A TNSN97070A TNSN97070A1 TN SN97070 A1 TNSN97070 A1 TN SN97070A1 TN TNSN97070 A TNTNSN97070 A TN TNSN97070A TN SN97070 A TNSN97070 A TN SN97070A TN SN97070 A1 TNSN97070 A1 TN SN97070A1
Authority
TN
Tunisia
Prior art keywords
preparation
compositions containing
imidazole derivatives
substituted imidazole
compounds
Prior art date
Application number
TNTNSN97070A
Other languages
English (en)
Inventor
Marfat Anthony
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN97070A1 publication Critical patent/TNSN97070A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE R, R1, et R2 REPRESENTENT DIVERS SUSBTITUANTS. ELLE CONCERNE EN OUTRE DES PROCEDES ET INTERMEDIAIRES POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITION POUR L'INHIBITION DE LA PHOSPHODIESTERASE (PDE) DE TYPE IV OU DE LA PRODUCTION DU FACTEUR DE NECROSE TUMORALE (TNF) CHEZ UN MAMMIFERE.
TNTNSN97070A 1996-05-03 1997-04-30 Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant TNSN97070A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1686196P 1996-05-03 1996-05-03

Publications (1)

Publication Number Publication Date
TNSN97070A1 true TNSN97070A1 (fr) 2005-03-15

Family

ID=21779401

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97070A TNSN97070A1 (fr) 1996-05-03 1997-04-30 Derives d'imidazole substitues, procede pour leur preparation, et compositions les contenant

Country Status (41)

Country Link
US (2) US6211222B1 (fr)
EP (1) EP0912521B1 (fr)
JP (1) JP3148254B2 (fr)
KR (1) KR100339935B1 (fr)
CN (2) CN1112359C (fr)
AP (4) AP1147A (fr)
AR (1) AR006906A1 (fr)
AT (1) ATE292626T1 (fr)
AU (1) AU725576B2 (fr)
BG (1) BG64211B1 (fr)
BR (1) BR9709051A (fr)
CA (2) CA2252982C (fr)
CO (1) CO4650038A1 (fr)
CZ (1) CZ292825B6 (fr)
DE (1) DE69732966T2 (fr)
DZ (1) DZ2217A1 (fr)
EA (1) EA002272B1 (fr)
ES (1) ES2238079T3 (fr)
GT (1) GT199700043A (fr)
HN (1) HN1997000046A (fr)
HR (1) HRP970227B1 (fr)
HU (1) HUP9902459A3 (fr)
ID (1) ID16856A (fr)
IL (2) IL126547A (fr)
IS (1) IS4871A (fr)
MA (1) MA24158A1 (fr)
MY (1) MY132499A (fr)
NO (1) NO312959B1 (fr)
NZ (1) NZ332240A (fr)
OA (1) OA10904A (fr)
PE (1) PE64598A1 (fr)
PL (1) PL329836A1 (fr)
SK (1) SK148298A3 (fr)
TN (1) TNSN97070A1 (fr)
TR (1) TR199802202T2 (fr)
TW (1) TW449585B (fr)
UA (1) UA65536C2 (fr)
UY (1) UY24532A1 (fr)
WO (1) WO1997042174A1 (fr)
YU (1) YU16397A (fr)
ZA (1) ZA973804B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
WO1997048697A1 (fr) 1996-06-19 1997-12-24 Rhone-Poulenc Rorer Limited Composes azabicycliques substitues et leur utilisation en tant qu'inhibiteurs de la production de tnf et de la photodiesterase cyclique d'amp
WO1998050367A1 (fr) * 1997-05-08 1998-11-12 Pfizer Products Inc. Procedes et produits intermediaires pour la preparation de derives d'indazole substitues
SK6252000A3 (en) * 1997-11-04 2001-11-06 Pfizer Prod Inc Indazole bioisostere replacement of catechol in therapeutically active compounds
NZ503995A (en) * 1997-11-04 2003-02-28 Pfizer Prod Inc Indazole compounds, and pharmaceutical compositions and uses thereof, based on indazole bioisostere replacement of catechol in PDE4 inhibitors
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
JP2000198734A (ja) * 1998-12-30 2000-07-18 Pfizer Inc 胃運動性減弱および関連疾患の治療のための運動性増強薬
US6303782B1 (en) * 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
PT1244649E (pt) * 1999-12-23 2005-06-30 Icos Corp Inibidores de fosfodiesterase especificos de mfa ciclica
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
CA2469939C (fr) 2001-12-14 2012-06-19 Applied Research Systems Ars Holding N.V. Procede permettant d'induire l'ovulation au moyen d'un modulateur du taux de camp non polypeptidique
US20040034084A1 (en) * 2002-05-24 2004-02-19 Celgene Corporation Methods for using JNK inhibitors for treating or preventing disease-related wasting
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US20050019366A1 (en) * 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
DE10318610A1 (de) 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
BRPI0710636A2 (pt) * 2006-04-21 2011-08-23 Centocor Inc antagonistas de cxcl 31 e o uso dos mesmos para o tratamento de doenças inflamatórias
EP2382975A3 (fr) 2006-05-09 2012-02-29 Braincells, Inc. Neurogénèse par modulation d'angiotensine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
EP2804603A1 (fr) 2012-01-10 2014-11-26 President and Fellows of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
WO2019090272A1 (fr) 2017-11-06 2019-05-09 Flx Bio, Inc. Modulateurs du récepteur de chimiokine pour le traitement de cancers positifs au virus epstein-barr

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JP2525286B2 (ja) * 1990-11-26 1996-08-14 日本原子力研究所 超耐熱性炭化ケイ素繊維の製造方法
TW223004B (fr) * 1991-11-25 1994-05-01 Sumitomo Chemical Co
DE69328964T2 (de) * 1992-03-09 2000-11-09 Zeneca Ltd., London Arylindazoline und ihre anwendung als herbizide
US5444038A (en) * 1992-03-09 1995-08-22 Zeneca Limited Arylindazoles and their use as herbicides
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US5554620A (en) * 1993-09-14 1996-09-10 Sterling Winthrop Inc. Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof
US5440038A (en) * 1993-12-07 1995-08-08 Miles Inc. Process for the purification of substituted 4-amino-1,2,4-triazine-5-ones
JPH09511758A (ja) * 1994-10-20 1997-11-25 フアイザー・インコーポレイテツド 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用
CA2203181C (fr) * 1994-10-21 2001-08-07 Robert L. Heimann Systeme de tampon evitant la corrosion destine a des produits metalliques
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
WO1998050367A1 (fr) * 1997-05-08 1998-11-12 Pfizer Products Inc. Procedes et produits intermediaires pour la preparation de derives d'indazole substitues

Also Published As

Publication number Publication date
IS4871A (is) 1998-10-16
KR100339935B1 (ko) 2002-07-18
IL126547A (en) 2003-03-12
KR20000010751A (ko) 2000-02-25
DZ2217A1 (fr) 2002-12-03
SK148298A3 (en) 2000-02-14
NO985095L (no) 1998-12-29
CZ349298A3 (cs) 1999-09-15
NO312959B1 (no) 2002-07-22
CN1217714A (zh) 1999-05-26
AR006906A1 (es) 1999-09-29
US6211222B1 (en) 2001-04-03
HRP970227B1 (en) 2002-06-30
EP0912521B1 (fr) 2005-04-06
NO985095D0 (no) 1998-11-02
JPH11508284A (ja) 1999-07-21
AP1147A (en) 2003-02-25
ZA973804B (en) 1998-11-02
AP0102304A0 (en) 1997-11-03
BG102946A (en) 1999-11-30
MY132499A (en) 2007-10-31
CO4650038A1 (es) 1998-09-03
DE69732966T2 (de) 2005-09-08
TR199802202T2 (xx) 1999-02-22
HK1019443A1 (en) 2000-02-11
AU1937397A (en) 1997-11-26
EA199800882A1 (ru) 1999-06-24
US6127398A (en) 2000-10-03
EP0912521A1 (fr) 1999-05-06
WO1997042174A1 (fr) 1997-11-13
CA2252982C (fr) 2002-10-08
CA2252982A1 (fr) 1997-11-13
GT199700043A (es) 1998-10-02
DE69732966D1 (de) 2005-05-12
PL329836A1 (en) 1999-04-12
AP2001002304A0 (en) 2001-12-31
UA65536C2 (en) 2004-04-15
HRP970227A2 (en) 2000-12-31
CA2389918A1 (fr) 1997-11-13
PE64598A1 (es) 1998-10-26
NZ332240A (en) 2000-07-28
AP2001002294A0 (en) 2001-12-31
HUP9902459A3 (en) 2001-10-29
IL126547A0 (en) 1999-08-17
AP9700975A0 (en) 1997-07-31
BR9709051A (pt) 1999-08-03
TW449585B (en) 2001-08-11
HUP9902459A2 (hu) 1999-11-29
CN1422849A (zh) 2003-06-11
YU16397A (sh) 1999-12-27
OA10904A (en) 2001-10-11
JP3148254B2 (ja) 2001-03-19
MA24158A1 (fr) 1997-12-31
CN1112359C (zh) 2003-06-25
AU725576B2 (en) 2000-10-12
UY24532A1 (es) 2000-09-29
BG64211B1 (bg) 2004-05-31
HN1997000046A (es) 1997-06-26
ID16856A (id) 1997-11-13
AP1146A (en) 2003-02-25
CZ292825B6 (cs) 2003-12-17
ES2238079T3 (es) 2005-08-16
IL152083A0 (en) 2003-05-29
ATE292626T1 (de) 2005-04-15
EA002272B1 (ru) 2002-02-28

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