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TNSN90006A1 - Procede de preparation de derives de cephalosporine - Google Patents

Procede de preparation de derives de cephalosporine

Info

Publication number
TNSN90006A1
TNSN90006A1 TNTNSN90006A TNSN90006A TNSN90006A1 TN SN90006 A1 TNSN90006 A1 TN SN90006A1 TN TNSN90006 A TNTNSN90006 A TN TNSN90006A TN SN90006 A TNSN90006 A TN SN90006A TN SN90006 A1 TNSN90006 A1 TN SN90006A1
Authority
TN
Tunisia
Prior art keywords
hydrogen atom
group
preparation
cephalosporin derivatives
cycloalcoxy
Prior art date
Application number
TNTNSN90006A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of TNSN90006A1 publication Critical patent/TNSN90006A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ON DECRIT UN PROCEDE DE PREPARATION DE DERIVES DE CEPHALOSPORINE DE FORMULE GENERALE......... DANS LAQUELLE R1 REPRESENTE UN ATOME D'HYDROGENE OU LE GROUPE METHYLE ET R2 REPRESENTE UN ATOME D'HYDROGENE OU LE GROUPE METHOXY, L'UN DES DEUX SUBSTITUANTS R1 OU R2 REPRESENTANT TOUJOURS UN ATOME D'HYDROGENE ; R3 REPRESENTE UN RADICAL ALKYLE EN C1-C5 A CHAINE DROITE OU RAMIFIEE QUI PEUT ETRE SUBSTITUE PAR UN GROUPE ALCOXY EN C1-C3, CYCLOALKYLE EN C3-C8 OU CYCLOALCOXY EN C2-C7 ; UN RADICAL CYCLOALKYLE EN C3-C8 OU CYCLOALCOXY EN C2-C7 DANS LE CAS OU R1 EST UN ATOME D'HYDROGENE ET R2 EST LE GROUPE METHOXY, R3 NE POUVANT PAS ETRE UN RADICAL ALKYLE EN C1-C4, ET DANS LAQUELLE LE GROUPE -OR1 EST EN POSITION SYN, AINSI QUE DE LEURS SELS D'ADDITION AVEC DES ACIDES PHYSIOLOGIQUEMENT ACCEPTABLES
TNTNSN90006A 1989-01-19 1990-01-19 Procede de preparation de derives de cephalosporine TNSN90006A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3901405A DE3901405A1 (de) 1989-01-19 1989-01-19 Cephalosporinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
TNSN90006A1 true TNSN90006A1 (fr) 1991-03-05

Family

ID=6372346

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN90006A TNSN90006A1 (fr) 1989-01-19 1990-01-19 Procede de preparation de derives de cephalosporine

Country Status (16)

Country Link
EP (1) EP0379132A3 (fr)
JP (1) JPH02229196A (fr)
CN (1) CN1044280A (fr)
AU (1) AU4853690A (fr)
CA (1) CA2008059A1 (fr)
DD (1) DD291561A5 (fr)
DE (1) DE3901405A1 (fr)
FI (1) FI900270A7 (fr)
HU (1) HU205936B (fr)
IL (1) IL93086A0 (fr)
NO (1) NO900252L (fr)
NZ (1) NZ232135A (fr)
PH (1) PH27125A (fr)
PT (1) PT92890A (fr)
TN (1) TNSN90006A1 (fr)
ZA (1) ZA90361B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
EP0531875B1 (fr) * 1991-09-07 2004-03-24 Aventis Pharma Deutschland GmbH Diastéréomère de l'ester 1-(1-isopropoxycarbonyloxy)éthyle de l'acide 3-céphen-4-carboxylique et procédé pour sa préparation
TW212181B (fr) * 1992-02-14 1993-09-01 Hoechst Ag
EP0570849B1 (fr) * 1992-05-21 1998-03-25 Hoechst Aktiengesellschaft Procédé de clivage de prodrug esters de céphalosporine en 7-amino-3-méthoxyméthylcéph-3-èm-4-carboxylique
PA8579701A1 (es) 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
CN114478391B (zh) * 2020-10-26 2023-09-15 南京锐志生物医药有限公司 奥硝唑酯类前药、药物组合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
US4486425A (en) * 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5896091A (ja) * 1981-12-01 1983-06-07 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリン類の製造法

Also Published As

Publication number Publication date
DE3901405A1 (de) 1990-07-26
AU4853690A (en) 1990-07-26
EP0379132A2 (fr) 1990-07-25
JPH02229196A (ja) 1990-09-11
CA2008059A1 (fr) 1990-07-19
HU205936B (en) 1992-07-28
NO900252D0 (no) 1990-01-18
FI900270A7 (fi) 1990-07-20
NZ232135A (en) 1991-07-26
HU900172D0 (en) 1990-03-28
PT92890A (pt) 1990-07-31
EP0379132A3 (fr) 1992-01-08
PH27125A (en) 1992-03-16
IL93086A0 (en) 1990-11-05
FI900270A0 (fi) 1990-01-17
NO900252L (no) 1990-07-20
ZA90361B (en) 1990-10-31
DD291561A5 (de) 1991-07-04
CN1044280A (zh) 1990-08-01
HUT54165A (en) 1991-01-28

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