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TN2015000408A1 - Compositions and methods for activating "stimulator of interferon gene"-dependent signalling - Google Patents

Compositions and methods for activating "stimulator of interferon gene"-dependent signalling

Info

Publication number
TN2015000408A1
TN2015000408A1 TN2015000408A TN2015000408A TN2015000408A1 TN 2015000408 A1 TN2015000408 A1 TN 2015000408A1 TN 2015000408 A TN2015000408 A TN 2015000408A TN 2015000408 A TN2015000408 A TN 2015000408A TN 2015000408 A1 TN2015000408 A1 TN 2015000408A1
Authority
TN
Tunisia
Prior art keywords
stimulator
activating
compositions
methods
present
Prior art date
Application number
TN2015000408A
Inventor
Thomas W Dubensky Jr
David B Kanne
Meredith Lai Ling Leong
Laura Hix Glickman
Russell E Vance
Edward Emile Lemmens
Original Assignee
Univ California
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/038525 external-priority patent/WO2014189805A1/en
Application filed by Univ California, Aduro Biotech Inc filed Critical Univ California
Publication of TN2015000408A1 publication Critical patent/TN2015000408A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2', 5', 2', 5' and 2', 5 ',3 ',5' CDNs, and prefereably Rp,Rp stereosiomers thereof.
TN2015000408A 2013-05-18 2015-09-10 Compositions and methods for activating "stimulator of interferon gene"-dependent signalling TN2015000408A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361825005P 2013-05-18 2013-05-18
PCT/US2014/038525 WO2014189805A1 (en) 2013-05-18 2014-05-18 Compositions and methods for activating "stimulator of interferon gene"-dependent signalling

Publications (1)

Publication Number Publication Date
TN2015000408A1 true TN2015000408A1 (en) 2017-01-03

Family

ID=57956460

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2015000408A TN2015000408A1 (en) 2013-05-18 2015-09-10 Compositions and methods for activating "stimulator of interferon gene"-dependent signalling

Country Status (2)

Country Link
MA (1) MA38587B1 (en)
TN (1) TN2015000408A1 (en)

Also Published As

Publication number Publication date
MA38587A1 (en) 2017-12-29
MA38587B1 (en) 2018-11-30

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