TN2014000528A1 - Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease - Google Patents

Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease

Info

Publication number: TN2014000528A1
Authority: TN; Tunisia
Prior art keywords: parkinsons; fragile; syndrome; treatment; reflux disease
Prior art date: 2012-08-23

Application number

TN2014000528A

Other languages

English (en)

Inventor

Dirk Behnke

David Carcache

Peter Ertl

Manuel Koller

David Orain

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-08-23

Filing date

2014-12-19

Publication date

2016-03-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47045285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2014000528(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-12-19 Application filed by Novartis Ag filed Critical Novartis Ag

2016-03-30 Publication of TN2014000528A1 publication Critical patent/TN2014000528A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TN2014000528A 2012-08-23 2014-12-19 Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease TN2014000528A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1215033.0A GB201215033D0 (en)	2012-08-23	2012-08-23	Diazepinone derivatives
PCT/IB2013/056782 WO2014030128A1 (fr)	2012-08-23	2013-08-21	Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux

Publications (1)

Publication Number	Publication Date
TN2014000528A1 true TN2014000528A1 (en)	2016-03-30

Family

ID=47045285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2014000528A TN2014000528A1 (en)	2012-08-23	2014-12-19	Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease

Country Status (43)

Country	Link
US (4)	US8853203B2 (fr)
EP (1)	EP2888259B1 (fr)
JP (2)	JP6169699B2 (fr)
KR (1)	KR102104149B1 (fr)
CN (1)	CN104520298B (fr)
AP (1)	AP2014008140A0 (fr)
AR (1)	AR092212A1 (fr)
AU (1)	AU2013307239B2 (fr)
BR (1)	BR112015003281A8 (fr)
CA (1)	CA2878564C (fr)
CL (1)	CL2015000416A1 (fr)
CR (1)	CR20150092A (fr)
CU (1)	CU20150016A7 (fr)
CY (1)	CY1120728T1 (fr)
DK (1)	DK2888259T3 (fr)
EA (1)	EA029493B1 (fr)
ES (1)	ES2672737T3 (fr)
GB (1)	GB201215033D0 (fr)
GT (1)	GT201500039A (fr)
HR (1)	HRP20180850T1 (fr)
HU (1)	HUE037971T2 (fr)
IL (1)	IL237062A (fr)
JO (1)	JOP20130250B1 (fr)
LT (1)	LT2888259T (fr)
MA (1)	MA37849A1 (fr)
MX (1)	MX365253B (fr)
MY (1)	MY170103A (fr)
NO (1)	NO2888259T3 (fr)
NZ (1)	NZ703628A (fr)
PE (1)	PE20150401A1 (fr)
PH (1)	PH12015500373A1 (fr)
PL (1)	PL2888259T3 (fr)
PT (1)	PT2888259T (fr)
RS (1)	RS57231B1 (fr)
SG (2)	SG11201500068QA (fr)
SI (1)	SI2888259T1 (fr)
TN (1)	TN2014000528A1 (fr)
TR (1)	TR201807174T4 (fr)
TW (1)	TWI616444B (fr)
UA (1)	UA114326C2 (fr)
UY (1)	UY34986A (fr)
WO (1)	WO2014030128A1 (fr)
ZA (1)	ZA201409345B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201215033D0 (en)	2012-08-23	2012-10-10	Novartis Ag	Diazepinone derivatives
KR20200035035A (ko)	2017-07-31	2020-04-01	노파르티스 아게	코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
US20220175793A1 (en) *	2019-01-29	2022-06-09	Novartis Ag	The use of an mglur5 antagonist for treating opioid analgesic tolerance

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853851A (en) *	1972-01-26	1974-12-10	Ciba Geigy Corp	Diazepinoisoquinolines
GB0128996D0 (en)	2001-12-04	2002-01-23	Novartis Ag	Organic compounds
JP2006521358A (ja) *	2003-03-26	2006-09-21	メルク　エンド　カムパニー　インコーポレーテッド	代謝調節型グルタミン酸受容体のベンズアミドモジュレータ
GB0413605D0 (en) *	2004-06-17	2004-07-21	Addex Pharmaceuticals Sa	Novel compounds
TW200811157A (en) *	2006-05-05	2008-03-01	Astrazeneca Ab	mGluR5 modulators I
CU20090172A6 (es)	2009-10-09	2011-10-05	Facultad De Quimica Universidad De La Habana	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
US8772301B2 (en) *	2009-12-18	2014-07-08	Sunovion Pharmaceuticals, Inc.	Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
ES2693152T3 (es)	2011-05-10	2018-12-07	Kyowa Hakko Kirin Co., Ltd.	Compuesto de pirimido-diazepinona
GB201215033D0 (en)	2012-08-23	2012-10-10	Novartis Ag	Diazepinone derivatives

2012
- 2012-08-23 GB GBGB1215033.0A patent/GB201215033D0/en not_active Ceased
2013
- 2013-08-21 SG SG11201500068QA patent/SG11201500068QA/en unknown
- 2013-08-21 WO PCT/IB2013/056782 patent/WO2014030128A1/fr not_active Ceased
- 2013-08-21 DK DK13783671.4T patent/DK2888259T3/en active
- 2013-08-21 NZ NZ703628A patent/NZ703628A/en not_active IP Right Cessation
- 2013-08-21 AU AU2013307239A patent/AU2013307239B2/en not_active Ceased
- 2013-08-21 EA EA201590415A patent/EA029493B1/ru not_active IP Right Cessation
- 2013-08-21 RS RS20180581A patent/RS57231B1/sr unknown
- 2013-08-21 SG SG10201701333WA patent/SG10201701333WA/en unknown
- 2013-08-21 CN CN201380042195.XA patent/CN104520298B/zh not_active Expired - Fee Related
- 2013-08-21 TR TR2018/07174T patent/TR201807174T4/tr unknown
- 2013-08-21 SI SI201331027T patent/SI2888259T1/en unknown
- 2013-08-21 BR BR112015003281A patent/BR112015003281A8/pt active Search and Examination
- 2013-08-21 MY MYPI2014003502A patent/MY170103A/en unknown
- 2013-08-21 LT LTEP13783671.4T patent/LT2888259T/lt unknown
- 2013-08-21 PL PL13783671T patent/PL2888259T3/pl unknown
- 2013-08-21 EP EP13783671.4A patent/EP2888259B1/fr active Active
- 2013-08-21 NO NO13783671A patent/NO2888259T3/no unknown
- 2013-08-21 AP AP2014008140A patent/AP2014008140A0/xx unknown
- 2013-08-21 PE PE2015000245A patent/PE20150401A1/es active IP Right Grant
- 2013-08-21 MA MA37849A patent/MA37849A1/fr unknown
- 2013-08-21 CA CA2878564A patent/CA2878564C/fr active Active
- 2013-08-21 MX MX2015002367A patent/MX365253B/es active IP Right Grant
- 2013-08-21 KR KR1020157003903A patent/KR102104149B1/ko not_active Expired - Fee Related
- 2013-08-21 PT PT137836714T patent/PT2888259T/pt unknown
- 2013-08-21 UA UAA201413654A patent/UA114326C2/uk unknown
- 2013-08-21 JP JP2015527996A patent/JP6169699B2/ja not_active Expired - Fee Related
- 2013-08-21 HU HUE13783671A patent/HUE037971T2/hu unknown
- 2013-08-21 ES ES13783671.4T patent/ES2672737T3/es active Active
- 2013-08-21 HR HRP20180850TT patent/HRP20180850T1/hr unknown
- 2013-08-22 JO JOP/2013/0250A patent/JOP20130250B1/ar active
- 2013-08-22 UY UY0001034986A patent/UY34986A/es unknown
- 2013-08-22 US US13/973,454 patent/US8853203B2/en active Active
- 2013-08-22 TW TW102130096A patent/TWI616444B/zh not_active IP Right Cessation
- 2013-08-23 AR ARP130102989A patent/AR092212A1/es not_active Application Discontinuation
2014
- 2014-08-19 US US14/462,813 patent/US9284331B2/en active Active
- 2014-12-18 ZA ZA2014/09345A patent/ZA201409345B/en unknown
- 2014-12-19 TN TN2014000528A patent/TN2014000528A1/fr unknown
2015
- 2015-02-02 IL IL237062A patent/IL237062A/en active IP Right Grant
- 2015-02-20 PH PH12015500373A patent/PH12015500373A1/en unknown
- 2015-02-20 CL CL2015000416A patent/CL2015000416A1/es unknown
- 2015-02-23 CU CUP2015000016A patent/CU20150016A7/es unknown
- 2015-02-23 CR CR20150092A patent/CR20150092A/es unknown
- 2015-02-23 GT GT201500039A patent/GT201500039A/es unknown
2016
- 2016-02-12 US US15/042,924 patent/US9650377B2/en active Active
2017
- 2017-04-28 US US15/581,642 patent/US20170305903A1/en not_active Abandoned
- 2017-06-28 JP JP2017125822A patent/JP2017226661A/ja not_active Withdrawn
2018
- 2018-06-07 CY CY181100599T patent/CY1120728T1/el unknown

Also Published As

Publication number	Publication date
MX365253B (es)	2019-05-28
AU2013307239B2 (en)	2015-12-24
US9650377B2 (en)	2017-05-16
DK2888259T3 (en)	2018-06-14
TWI616444B (zh)	2018-03-01
NO2888259T3 (fr)	2018-08-04
KR20150044897A (ko)	2015-04-27
CN104520298A (zh)	2015-04-15
GB201215033D0 (en)	2012-10-10
BR112015003281A8 (pt)	2018-01-16
PT2888259T (pt)	2018-06-06
PE20150401A1 (es)	2015-04-16
CL2015000416A1 (es)	2015-04-24
RS57231B1 (sr)	2018-07-31
AU2013307239A1 (en)	2015-01-29
GT201500039A (es)	2018-11-27
UY34986A (es)	2014-03-31
WO2014030128A1 (fr)	2014-02-27
US20140057902A1 (en)	2014-02-27
MX2015002367A (es)	2015-06-03
JP6169699B2 (ja)	2017-07-26
US20160159795A1 (en)	2016-06-09
PH12015500373B1 (en)	2015-04-20
EA029493B1 (ru)	2018-04-30
CN104520298B (zh)	2016-10-19
US20140357625A1 (en)	2014-12-04
JOP20130250B1 (ar)	2021-08-17
CR20150092A (es)	2015-05-04
TW201412736A (zh)	2014-04-01
US8853203B2 (en)	2014-10-07
US9284331B2 (en)	2016-03-15
PL2888259T3 (pl)	2018-08-31
IL237062A (en)	2016-11-30
UA114326C2 (uk)	2017-05-25
LT2888259T (lt)	2018-06-11
ES2672737T3 (es)	2018-06-15
AP2014008140A0 (en)	2014-12-31
CU20150016A7 (es)	2015-07-30
MA37849A1 (fr)	2017-09-29
HK1206008A1 (en)	2015-12-31
JP2017226661A (ja)	2017-12-28
BR112015003281A2 (pt)	2017-07-04
HRP20180850T1 (hr)	2018-06-29
EA201590415A1 (ru)	2015-06-30
JP2015526461A (ja)	2015-09-10
ZA201409345B (en)	2015-12-23
SG10201701333WA (en)	2017-04-27
NZ703628A (en)	2018-05-25
KR102104149B1 (ko)	2020-04-24
MY170103A (en)	2019-07-05
PH12015500373A1 (en)	2015-04-20
TR201807174T4 (tr)	2018-06-21
SG11201500068QA (en)	2015-05-28
CA2878564C (fr)	2021-08-03
EP2888259B1 (fr)	2018-03-07
HUE037971T2 (hu)	2018-10-29
CY1120728T1 (el)	2019-12-11
US20170305903A1 (en)	2017-10-26
SI2888259T1 (en)	2018-07-31
CA2878564A1 (fr)	2014-02-27
EP2888259A1 (fr)	2015-07-01
AR092212A1 (es)	2015-04-08

Publication	Publication Date	Title
PH12013500473A1 (en)	2013-05-06	Triazine-oxadiazoles
PH12013501600A1 (en)	2013-09-30	Novel heterocyclic derivatives
EA201300200A1 (ru)	2013-06-28	N-((6-аминопиридин-3-ил)метил)гетероарилкарбоксамиды в качестве ингибиторов калликреина в плазме
IN2015DN03998A (fr)	2015-10-02
EA201591064A1 (ru)	2015-09-30	Новые производные пиридина
IN2012DN02139A (fr)	2015-08-07
TW201129554A (en)	2011-09-01	4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds
PH12014502743A1 (en)	2015-02-02	Carbamate/urea derivatives
IN2014DN01629A (fr)	2015-05-15
PH12018501709A1 (en)	2019-08-14	Naphthridinedione derivatives
PH12016500577B1 (en)	2016-06-20	Piperazine derivatives and the use thereof as medicament
WO2015002755A3 (fr)	2015-10-29	Composés pour le traitement du paludisme
PH12015500373A1 (en)	2015-04-20	Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease
MX2015015251A (es)	2016-02-09	Derivados de la quinolona.
TN2013000089A1 (en)	2014-06-25	Triazine-oxadiazoles
TN2013000327A1 (en)	2015-01-20	Novel heterocyclic derivatives
MA37778A1 (fr)	2016-05-31	Dérivés de carbamate/urée
UA110849C2 (uk)	2016-02-25	Сполуки для лікування та профілактики респіраторного синцитіального вірусного захворювання