TN2013000440A1 - Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids - Google Patents
Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acidsInfo
- Publication number
- TN2013000440A1 TN2013000440A1 TNP2013000440A TN2013000440A TN2013000440A1 TN 2013000440 A1 TN2013000440 A1 TN 2013000440A1 TN P2013000440 A TNP2013000440 A TN P2013000440A TN 2013000440 A TN2013000440 A TN 2013000440A TN 2013000440 A1 TN2013000440 A1 TN 2013000440A1
- Authority
- TN
- Tunisia
- Prior art keywords
- methyl
- organic acids
- imidazol
- pyridinyl
- pyrimidinyl
- Prior art date
Links
- 150000007524 organic acids Chemical class 0.000 title abstract 2
- 235000005985 organic acids Nutrition 0.000 title abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 239000005536 L01XE08 - Nilotinib Substances 0.000 abstract 3
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 abstract 3
- 229960001346 nilotinib Drugs 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 1
- 230000009246 food effect Effects 0.000 abstract 1
- 235000021471 food effect Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Soluble pharmaceutical compositions of amorphous nilotinib or a pharmaceutically acceptable salt thereof were invented using one or more organic acids that function as a solubilizing agent, increasing the bioavailability of nilotinib and supressing the food effect associated with certain compositions of nilotinib. The pharmaceutical compositions are in th form of solid oral dosage forms, including capsules and tablets.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161541306P | 2011-09-30 | 2011-09-30 | |
| PCT/US2012/042205 WO2012174082A1 (en) | 2011-06-14 | 2012-06-13 | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2013000440A1 true TN2013000440A1 (en) | 2015-03-30 |
Family
ID=52394773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2013000440A TN2013000440A1 (en) | 2011-09-30 | 2013-10-29 | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids |
Country Status (2)
| Country | Link |
|---|---|
| CU (1) | CU20130165A7 (en) |
| TN (1) | TN2013000440A1 (en) |
-
2013
- 2013-10-29 TN TNP2013000440A patent/TN2013000440A1/en unknown
- 2013-12-16 CU CU2013000165A patent/CU20130165A7/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CU20130165A7 (en) | 2014-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG194756A1 (en) | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids | |
| PH12016501310B1 (en) | Pharmaceutical compositions comprising azd9291 | |
| EA201291421A1 (en) | ORAL PHARMACEUTICAL MEDICINE FORMS CONTAINING ETEXILATE DAGIGATRAN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | |
| SG10201810985XA (en) | Tofacitinib oral sustained release dosage forms | |
| EA201491285A1 (en) | IMPROVED COMPOSITIONS AND METHODS OF DELIVERY OF OMEPRAZOL AND ACETYLSALICYLIC ACID | |
| IL233282A (en) | Crystalline forms of 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine monohydrochloride, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments | |
| EA201201263A1 (en) | PHARMACEUTICAL COMPOSITION CONTAINING DAGIGATRAN ETEXYLATE | |
| TN2012000371A1 (en) | Pyrazole compounds as crth2 antagonists | |
| EA201201202A1 (en) | ORAL PHARMACEUTICAL COMPOSITION CONTAINING DABIGATRANE EXTILE | |
| PH12015500823A1 (en) | Modified release formulations for oprozomib | |
| IL230487B (en) | 6-(n-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5- yl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-n-methylbenzofuran-3-carboxamide compounds, pharmaceutically acceptable salts thereof and pharmaceutical composition comprising them | |
| JO3587B1 (en) | Oral dosage forms of bendamustine | |
| TN2014000177A1 (en) | Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl- 1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation | |
| IN2014CN02343A (en) | Oral formulations containing hyaluronic acid for sustained drug release | |
| TR201803451T4 (en) | OLMESARTAN FORMULATIONS. | |
| TN2013000440A1 (en) | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids | |
| IN2012CH05549A (en) | ||
| WO2011161223A3 (en) | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts | |
| TH148311A (en) | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazole-1-yl)-3-(trifluoromethyl)phenyl] benzamide that can be dissolved using organic acids. | |
| MA35169B1 (en) | Modified release of 4-methyl-3- [[4- (3-pyridinyl) -2-pyrimidinyl] amino] -n-5- (4-methyl-1H-imidazol-1-yl) -3- (trifluoromethyl) phenyl] ] benzamide solubilized with organic acids | |
| TH148311B (en) | Modified release of 4- methyl-3 - [[4- (3-pyridinil) -2-pyrimidinyl] amino] -N- [5- (4-methyl-1H-imi Dasol-1-il) -3- (trifulformethyl) phenyl] soluble benzamides using organic acids | |
| MY183976A (en) | Pharmaceutical composition for oral administration with improved dissolution and/or absorption | |
| TR201005911A2 (en) | A drug formulation with improved dissolution profile. | |
| UA110792C2 (en) | Pharmaceutical form bendamustine for oral use | |
| ES2422657A1 (en) | Solid cilostazol pharmaceutical composition |