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Priority claimed from PCT/JP2011/071325external-prioritypatent/WO2012039371A1/en
Application filed by Eisai R&D Man Co LtdfiledCriticalEisai R&D Man Co Ltd
Publication of TN2013000119A1publicationCriticalpatent/TN2013000119A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A compound represented by formula (A) [wherein Q represents -CH- or a nitrogen atom; R1a and R1b independently represent a C1-6 alkyl group or the like; R1c represents a hydrogen atom or the like; R2a, R2b, R2c and R2d independently represent a hydrogen atom, a halogen atom or the like; R3a, R3b and R3c independently represent a hydrogen atom, a halogen atom or the like; and R3d represents a hydrogen atom or the like] or a pharmaceutically acceptable salt thereof, which has an antagonistic activity on an orexin receptor, and therefore can be used as a therapeutic agent for sleep disorders, such as insomnia, on which the antagonistic activity on an orexin receptor is effective.
Crystalline forms of n-[3-fluoro-4-([6-(methyloxy)-7-[(morpholin-4ylpropyl)oxy}]-quinolin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide