TN2011000223A1 - Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof - Google Patents

Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof

Info

Publication number: TN2011000223A1
Authority: TN; Tunisia
Prior art keywords: preparation; piperidinone; therapeutic use; substituted; substituted tetrahydropyran
Prior art date: 2009-08-28

Application number

TN2011000223A

Other languages

English (en)

Inventor

Ryan Hartung

David Stefany

Zhongli Gao

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-28

Filing date

2011-05-06

Publication date

2012-12-17

2011-05-06 Application filed by Sanofi Sa filed Critical Sanofi Sa

2012-12-17 Publication of TN2011000223A1 publication Critical patent/TN2011000223A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

TN2011000223A 2009-08-28 2011-05-06 Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof TN2011000223A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0955909		2009-08-28
PCT/US2009/066666 WO2010065798A1 (fr)	2008-12-05	2009-12-04	Pyrrolidinone et pipéridinone spiro à substitution de tétrahydropyranne, sa preparation et son utilisation thérapeutique

Publications (1)

Publication Number	Publication Date
TN2011000223A1 true TN2011000223A1 (en)	2012-12-17

Family

ID=41665099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2011000223A TN2011000223A1 (en)	2009-08-28	2011-05-06	Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof

Country Status (27)

Country	Link
US (2)	US8217052B2 (fr)
EP (1)	EP2373659B1 (fr)
JP (1)	JP5410544B2 (fr)
KR (1)	KR101682889B1 (fr)
CN (1)	CN102239170B (fr)
AR (1)	AR074467A1 (fr)
AU (1)	AU2009322243B2 (fr)
CA (1)	CA2745715C (fr)
CO (1)	CO6390059A2 (fr)
CR (1)	CR20110289A (fr)
DO (1)	DOP2011000166A (fr)
EC (1)	ECSP11011109A (fr)
ES (1)	ES2507574T3 (fr)
HN (1)	HN2011001487A (fr)
IL (1)	IL213292A (fr)
MA (1)	MA32945B1 (fr)
MX (1)	MX2011004791A (fr)
MY (1)	MY150789A (fr)
NZ (1)	NZ593150A (fr)
PA (1)	PA8852301A1 (fr)
PE (1)	PE20110773A1 (fr)
RU (1)	RU2519778C2 (fr)
TN (1)	TN2011000223A1 (fr)
TW (1)	TWI441826B (fr)
UA (1)	UA104880C2 (fr)
WO (1)	WO2010065798A1 (fr)
ZA (1)	ZA201103261B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR074466A1 (es)	2008-12-05	2011-01-19	Sanofi Aventis	Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
EP2569294B1 (fr)	2010-05-11	2015-03-11	Sanofi	Bipyrrolidine carboxamides n-heteroaromatiques, leur preparation et usage therapeutique
WO2011143163A1 (fr) *	2010-05-11	2011-11-17	Sanofi	Bipyrrolidines n-phényl spirolactame substituées, procédé de préparation et usage thérapeutique associés
WO2011143145A1 (fr)	2010-05-11	2011-11-17	Sanofi	Dérivés n-alkyl et n-acyl tétrahydro-isoquinoline substitués, procédé de préparation et application thérapeutiques associés
EP2569280B1 (fr)	2010-05-11	2015-02-25	Sanofi	Phényl-cycloalkyl-pyrrolidine- (pipéridine-) spirolactames et amides substituées, leur préparation et utilisation thérapeutique
TW201206444A (en)	2010-05-11	2012-02-16	Sanofi Aventis	Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
TW201202251A (en) *	2010-05-11	2012-01-16	Sanofi Aventis	Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
JP2013529198A (ja)	2010-05-11	2013-07-18	サノフイ	置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3256276A (en) *	1961-02-17	1966-06-14	Geschickter Fund Med Res	Substituted spiroimides
US3258276A (en)	1964-04-06	1966-06-28	Charles E Murcott	Utility chair
EP1444219A1 (fr) *	2001-10-12	2004-08-11	Novo Nordisk A/S	Piperidines substituees et leur utilisation dans le traitement de maladies liees au recepteur histaminique h3
US6889262B1 (en)	2002-06-26	2005-05-03	Advanced Micro Devices, Inc.	Direct transaction mode for peripheral devices
JP2006505590A (ja) *	2002-10-23	2006-02-16	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン
US7223788B2 (en)	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
CA2551037A1 (fr) *	2003-09-22	2005-03-31	Banyu Pharmaceutical Co., Ltd.	Nouveau derive de piperidine
JP5193033B2 (ja) *	2005-07-01	2013-05-08	イーライリリーアンドカンパニー	ヒスタミンｈ３受容体薬剤、製剤及び治療的使用
WO2007055418A1 (fr) *	2005-11-10	2007-05-18	Banyu Pharmaceutical Co., Ltd.	Derive spiro aza-substitue
US7351708B2 (en)	2005-12-16	2008-04-01	Hoffmann-La Roche Inc.	Pyrrolo [2,3-b] pyridine derivatives
US20080247964A1 (en) *	2006-05-08	2008-10-09	Yuelian Xu	Substituted azaspiro derivatives
CA2653062A1 (fr) *	2006-05-23	2007-11-29	Transtech Pharma, Inc.	Nouveaux medicaments
WO2008002820A2 (fr)	2006-06-29	2008-01-03	Janssen Pharmaceutica N.V.	Composés de benzylamine substituée
US20100317679A1 (en)	2007-09-21	2010-12-16	Ligand Pharmaceuticals, Inc.	Substituted aryl-fused spirocyclic amines
WO2009052063A1 (fr)	2007-10-17	2009-04-23	Sanofi-Aventis	Amides de n-phényl-pyrrolidinylméthylpyrrolidine substitués et leur utilisation thérapeutique comme modulateurs du récepteur h3 de l'histamine
CA2702482C (fr)	2007-10-17	2012-11-27	Sanofi-Aventis	Carboxamides de n-phenyl-bipyrrolidine substitues et leur utilisation therapeutique
ATE525351T1 (de)	2007-10-17	2011-10-15	Sanofi Sa	Substituierte n-phenyl- bipyrrolidincarbonsäureamide und deren therapeutische verwendung
AR074466A1 (es)	2008-12-05	2011-01-19	Sanofi Aventis	Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.

2009
- 2009-12-03 AR ARP090104667A patent/AR074467A1/es unknown
- 2009-12-04 AU AU2009322243A patent/AU2009322243B2/en not_active Ceased
- 2009-12-04 MX MX2011004791A patent/MX2011004791A/es active IP Right Grant
- 2009-12-04 MA MA33989A patent/MA32945B1/fr unknown
- 2009-12-04 ES ES09775421.2T patent/ES2507574T3/es active Active
- 2009-12-04 TW TW098141444A patent/TWI441826B/zh not_active IP Right Cessation
- 2009-12-04 PA PA20098852301A patent/PA8852301A1/es unknown
- 2009-12-04 CA CA2745715A patent/CA2745715C/fr not_active Expired - Fee Related
- 2009-12-04 KR KR1020117014404A patent/KR101682889B1/ko not_active Expired - Fee Related
- 2009-12-04 PE PE2011001127A patent/PE20110773A1/es not_active Application Discontinuation
- 2009-12-04 CN CN200980148490.7A patent/CN102239170B/zh active Active
- 2009-12-04 NZ NZ593150A patent/NZ593150A/xx not_active IP Right Cessation
- 2009-12-04 WO PCT/US2009/066666 patent/WO2010065798A1/fr not_active Ceased
- 2009-12-04 UA UAA201108412A patent/UA104880C2/uk unknown
- 2009-12-04 JP JP2011539715A patent/JP5410544B2/ja active Active
- 2009-12-04 MY MYPI20112068 patent/MY150789A/en unknown
- 2009-12-04 RU RU2011127382/04A patent/RU2519778C2/ru not_active IP Right Cessation
- 2009-12-04 EP EP09775421.2A patent/EP2373659B1/fr active Active
2011
- 2011-05-05 ZA ZA2011/03261A patent/ZA201103261B/en unknown
- 2011-05-06 TN TN2011000223A patent/TN2011000223A1/fr unknown
- 2011-05-27 CR CR20110289A patent/CR20110289A/es unknown
- 2011-05-31 IL IL213292A patent/IL213292A/en not_active IP Right Cessation
- 2011-06-01 DO DO2011000166A patent/DOP2011000166A/es unknown
- 2011-06-02 US US13/151,925 patent/US8217052B2/en active Active
- 2011-06-02 CO CO11068492A patent/CO6390059A2/es active IP Right Grant
- 2011-06-03 EC EC2011011109A patent/ECSP11011109A/es unknown
- 2011-06-03 HN HN2011001487A patent/HN2011001487A/es unknown
2012
- 2012-05-30 US US13/483,503 patent/US8383814B2/en active Active

Also Published As

Publication number	Publication date
MY150789A (en)	2014-02-28
DOP2011000166A (es)	2011-10-31
ES2507574T3 (es)	2014-10-15
KR101682889B1 (ko)	2016-12-06
KR20110095911A (ko)	2011-08-25
WO2010065798A1 (fr)	2010-06-10
AR074467A1 (es)	2011-01-19
RU2011127382A (ru)	2013-01-10
US8217052B2 (en)	2012-07-10
CA2745715A1 (fr)	2010-06-10
IL213292A0 (en)	2011-07-31
CR20110289A (es)	2011-09-21
NZ593150A (en)	2012-10-26
PA8852301A1 (es)	2010-07-27
ZA201103261B (en)	2012-01-25
IL213292A (en)	2014-01-30
TW201033219A (en)	2010-09-16
AU2009322243A1 (en)	2011-06-23
RU2519778C2 (ru)	2014-06-20
PE20110773A1 (es)	2011-10-26
US20120238757A1 (en)	2012-09-20
EP2373659A1 (fr)	2011-10-12
JP5410544B2 (ja)	2014-02-05
JP2012511011A (ja)	2012-05-17
ECSP11011109A (es)	2011-11-30
TWI441826B (zh)	2014-06-21
CN102239170A (zh)	2011-11-09
US8383814B2 (en)	2013-02-26
MA32945B1 (fr)	2012-01-02
CO6390059A2 (es)	2012-02-29
US20110251225A1 (en)	2011-10-13
MX2011004791A (es)	2011-05-30
HN2011001487A (es)	2013-12-02
AU2009322243B2 (en)	2015-07-16
UA104880C2 (uk)	2014-03-25
EP2373659B1 (fr)	2014-07-30
CN102239170B (zh)	2014-08-20
CA2745715C (fr)	2014-01-28

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