TN2011000100A1 - Galenical formulations of organic compounds - Google Patents
Galenical formulations of organic compoundsInfo
- Publication number
- TN2011000100A1 TN2011000100A1 TN2011000100A TN2011000100A TN2011000100A1 TN 2011000100 A1 TN2011000100 A1 TN 2011000100A1 TN 2011000100 A TN2011000100 A TN 2011000100A TN 2011000100 A TN2011000100 A TN 2011000100A TN 2011000100 A1 TN2011000100 A1 TN 2011000100A1
- Authority
- TN
- Tunisia
- Prior art keywords
- minutes
- dose combination
- organic compounds
- fixed dose
- pharmaceutical oral
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000002894 organic compounds Chemical class 0.000 title 1
- 229940000425 combination drug Drugs 0.000 abstract 3
- 238000004090 dissolution Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
- 229960004601 aliskiren Drugs 0.000 abstract 1
- 229940075710 aliskiren and amlodipine Drugs 0.000 abstract 1
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 abstract 1
- 229960000528 amlodipine Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a pharmaceutical oral fixed dose combination comprising a) a therapeutically effective amount of Aliskiren, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Amlodipine, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical oral fixed dose combination shows an in vitro dissolution of component (a) of 60% or less after 10 minutes and 98% or less after 20 minutes, and a dissolution profile of component (b) of 50 % or more after 20 minutes, and 70% or more after 30 minutes at pH 2, said pharmaceutical oral fixed dose combination being bioequivalent, or close to reaching bioequivalence, to a free dose combination of Aliskiren and Amlodipine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/057750 WO2010033954A2 (en) | 2008-09-22 | 2009-09-22 | Galenical formulations of organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000100A1 true TN2011000100A1 (en) | 2012-09-05 |
Family
ID=55024397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000100A TN2011000100A1 (en) | 2009-09-22 | 2011-02-28 | Galenical formulations of organic compounds |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2011000100A1 (en) |
-
2011
- 2011-02-28 TN TN2011000100A patent/TN2011000100A1/en unknown
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