TN2010000619A1 -
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR APPLICATION AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
- Google Patents
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR APPLICATION AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
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Priority claimed from PCT/FR2009/051408external-prioritypatent/WO2010007318A2/en
Application filed by Sanofi AventisfiledCriticalSanofi Aventis
Publication of TN2010000619A1publicationCriticalpatent/TN2010000619A1/en
L'invention concerne les nouveaux produits de formule (I): dans laquelle : n = 0,1 ou 2; X représente H, HaI ou alk; R représente H, NH2, NHaIk, N(alk)2; Ra représente H; HaI; -O-cycloalkyle; -O-alkyle, -O-aryle; -O-hétéroaryle; - NRd(cycloalkyle); -NRd(alkyle); -NRd(aryle); -NRd(hétéroaryle); alkyle; cycloalkyle; hétérocycloalkyle; aryle ou hétéroaryle; tous éventuellement substitués; Rb représente H, Rc, -COORc-CO-Rc ou -CO-NRcRd; avec Rc représente alkyle, cycloalkyle, hétérocycloalkyle, aryle et hétéroaryle, tous éventuellement substitués; Rd représente H, alk ou cycloalkyle; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de MET.The invention relates to novel products of formula (I): wherein: n = 0.1 or 2; X represents H, HaI or alk; R is H, NH2, NHaIk, N (alk) 2; Ra represents H; Hal; -O-cycloalkyl; -O-alkyl, -O-aryl; -O-heteroaryl; NRd (cycloalkyl); -Nrd (alkyl); -Nrd (aryl); -Nrd (heteroaryl); alkyl; cycloalkyl; heterocycloalkyl; aryl or heteroaryl; all possibly substituted; Rb is H, Rc, -COORc-CO-Rc or -CO-NRcRd; with Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all isomeric forms and salts, as medicaments especially as MET inhibitors.
TNP2010000619A2009-07-162010-12-29
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR APPLICATION AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
TN2010000619A1
(en)
Novel imidazo[1,2-a]pyrimidine derivatives, method for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use in particular as met inhibitors
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR APPLICATION AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
NOVEL 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS
NOVEL IMIDAZO [1,2-a] PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
Novel triazolo(4,3-a)pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as met inhibitors
Derivatives 6 - (substitute 6 - triazolopridzine - sulfanil 5) (A-fluoro-benzotiazole and 5-fluoro-benzimidazole: preparation and use as drugs and as inhibitors)
NOVEL IMIDAZO [1,2-a] PYRIMIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR APPLICATION AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS
Substitution derivatives of n6-benzyladenosine-5´-monophosphate, methods of preparation thereof, use thereof as medicaments, and therapeutic preparations containing these compounds