TN2010000467A1 - Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1 - Google Patents
Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1Info
- Publication number
- TN2010000467A1 TN2010000467A1 TNP2010000467A TN2010000467A TN2010000467A1 TN 2010000467 A1 TN2010000467 A1 TN 2010000467A1 TN P2010000467 A TNP2010000467 A TN P2010000467A TN 2010000467 A TN2010000467 A TN 2010000467A TN 2010000467 A1 TN2010000467 A1 TN 2010000467A1
- Authority
- TN
- Tunisia
- Prior art keywords
- hydroxysterioid
- dehydrogenase
- beta
- cyclic inhibitors
- cortisol
- Prior art date
Links
- 101710088194 Dehydrogenase Proteins 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960000890 hydrocortisone Drugs 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960004544 cortisone Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 -HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/002653 WO2009134400A1 (en) | 2008-05-01 | 2009-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2010000467A1 true TN2010000467A1 (en) | 2012-05-24 |
Family
ID=45478607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2010000467A TN2010000467A1 (en) | 2009-04-30 | 2010-10-14 | Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1 |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5784006B2 (en) |
| AP (1) | AP2011005948A0 (en) |
| CL (1) | CL2014001815A1 (en) |
| CO (1) | CO6501139A2 (en) |
| IL (1) | IL215249A (en) |
| MX (1) | MX2011011503A (en) |
| NZ (1) | NZ595473A (en) |
| PE (1) | PE20120794A1 (en) |
| TN (1) | TN2010000467A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5679997B2 (en) * | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009017671A1 (en) * | 2007-07-26 | 2009-02-05 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
-
2010
- 2010-04-30 AP AP2011005948A patent/AP2011005948A0/en unknown
- 2010-04-30 NZ NZ595473A patent/NZ595473A/en not_active IP Right Cessation
- 2010-04-30 JP JP2012508772A patent/JP5784006B2/en active Active
- 2010-04-30 MX MX2011011503A patent/MX2011011503A/en active IP Right Grant
- 2010-04-30 PE PE2011001866A patent/PE20120794A1/en not_active Application Discontinuation
- 2010-10-14 TN TNP2010000467A patent/TN2010000467A1/en unknown
-
2011
- 2011-09-20 IL IL215249A patent/IL215249A/en not_active IP Right Cessation
- 2011-10-05 CO CO11131281A patent/CO6501139A2/en not_active Application Discontinuation
-
2014
- 2014-07-08 CL CL2014001815A patent/CL2014001815A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL215249A (en) | 2014-12-31 |
| MX2011011503A (en) | 2011-11-18 |
| CL2014001815A1 (en) | 2015-02-13 |
| IL215249A0 (en) | 2011-12-29 |
| PE20120794A1 (en) | 2012-07-26 |
| CO6501139A2 (en) | 2012-08-15 |
| NZ595473A (en) | 2014-01-31 |
| HK1169409A1 (en) | 2013-01-25 |
| JP2012525440A (en) | 2012-10-22 |
| JP5784006B2 (en) | 2015-09-24 |
| AP2011005948A0 (en) | 2011-10-31 |
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