TN2010000351A1 - Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereof - Google Patents
Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereofInfo
- Publication number
- TN2010000351A1 TN2010000351A1 TNP2010000351A TN2010000351A TN2010000351A1 TN 2010000351 A1 TN2010000351 A1 TN 2010000351A1 TN P2010000351 A TNP2010000351 A TN P2010000351A TN 2010000351 A TN2010000351 A TN 2010000351A TN 2010000351 A1 TN2010000351 A1 TN 2010000351A1
- Authority
- TN
- Tunisia
- Prior art keywords
- alkyl
- compositions containing
- containing same
- carbazole derivatives
- optionally substituted
- Prior art date
Links
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 title 1
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 title 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 title 1
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 mercapto, amino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R'1; R is selected from the group comprising Formula (II) with R1 and/or R'1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkythio, or carboxy that is free or esterified by an alkyl, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulfonamide, NH-SO2-alkyl, S(O)2-NHalkyl, or S(O2)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is O, S, NR2, C(O), S(O), or S(O)2; Z is optionally substituted H, HaI, -O-R2 or –NH-R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/FR2009/000267 WO2009122034A2 (en) | 2008-03-14 | 2009-03-13 | Novel hsp90 inhibitory carbazole derivatives, compositions containing same, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2010000351A1 true TN2010000351A1 (en) | 2011-12-29 |
Family
ID=55024481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2010000351A TN2010000351A1 (en) | 2009-03-13 | 2010-07-27 | Novel hsp90 inhibitory carbazole derivatives compositions containing same and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2010000351A1 (en) |
-
2010
- 2010-07-27 TN TNP2010000351A patent/TN2010000351A1/en unknown
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