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TN2009000327A1 - Procede pour la preparation d'un derive de benzimidazole - Google Patents

Procede pour la preparation d'un derive de benzimidazole

Info

Publication number
TN2009000327A1
TN2009000327A1 TNP2009000327A TN2009000327A TN2009000327A1 TN 2009000327 A1 TN2009000327 A1 TN 2009000327A1 TN P2009000327 A TNP2009000327 A TN P2009000327A TN 2009000327 A TN2009000327 A TN 2009000327A TN 2009000327 A1 TN2009000327 A1 TN 2009000327A1
Authority
TN
Tunisia
Prior art keywords
preparation
benzimidazole derivative
exexilate
synthesis
compound
Prior art date
Application number
TNP2009000327A
Other languages
English (en)
Inventor
Wolfgang Broeder
Rainer Sobotta
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TN2009000327A1 publication Critical patent/TN2009000327A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un procédé de préparation du composé de formule 1 : un produit intermédiaire valable dans la synthèse de la substance active pharmaceutique etexilate de dabigatran.
TNP2009000327A 2007-02-06 2009-07-31 Procede pour la preparation d'un derive de benzimidazole TN2009000327A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101822A EP1956018A1 (fr) 2007-02-06 2007-02-06 Procédé de préparation d'un dérivé du benzimidazole
PCT/EP2008/051397 WO2008095928A1 (fr) 2007-02-06 2008-02-05 Procédé de préparation d'un dérivé de benzimidazole

Publications (1)

Publication Number Publication Date
TN2009000327A1 true TN2009000327A1 (fr) 2010-12-31

Family

ID=38166801

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000327A TN2009000327A1 (fr) 2007-02-06 2009-07-31 Procede pour la preparation d'un derive de benzimidazole

Country Status (33)

Country Link
US (2) US8119810B2 (fr)
EP (2) EP1956018A1 (fr)
JP (1) JP5247728B2 (fr)
KR (1) KR20090116781A (fr)
CN (1) CN101600709B (fr)
AR (1) AR065196A1 (fr)
AT (1) ATE476430T1 (fr)
AU (1) AU2008212908B2 (fr)
BR (1) BRPI0807197A2 (fr)
CA (1) CA2675624C (fr)
CL (1) CL2008000355A1 (fr)
CY (1) CY1111045T1 (fr)
DE (1) DE602008002057D1 (fr)
DK (1) DK2118090T3 (fr)
EA (1) EA015967B1 (fr)
EC (1) ECSP099509A (fr)
ES (1) ES2349905T3 (fr)
HR (1) HRP20100458T1 (fr)
IL (1) IL199330A (fr)
MA (1) MA31118B1 (fr)
MX (1) MX2009006834A (fr)
MY (1) MY148629A (fr)
NZ (1) NZ579133A (fr)
PE (1) PE20081737A1 (fr)
PL (1) PL2118090T3 (fr)
PT (1) PT2118090E (fr)
SI (1) SI2118090T1 (fr)
TN (1) TN2009000327A1 (fr)
TW (1) TWI417291B (fr)
UA (1) UA94988C2 (fr)
UY (1) UY30888A1 (fr)
WO (1) WO2008095928A1 (fr)
ZA (1) ZA200906050B (fr)

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DE102005061623A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
CZ305085B6 (cs) * 2008-03-14 2015-04-29 Zentiva, K.S. Způsob přípravy dabigatranu
MX2010010647A (es) * 2008-03-28 2010-10-20 Boehringer Ingelheim Int Proceso para preparar formulaciones de dabigatran para administracion oral.
CA2728058C (fr) * 2008-06-16 2016-05-17 Boehringer Ingelheim International Gmbh Procede de fabrication d'un produit intermediaire de dabigatran etexilate
BRPI0915942A2 (pt) 2008-07-14 2019-04-09 Boehringer Ingelheim International Gmbh método para produção de compostos medicinais contendo dabigatrana
WO2010055021A1 (fr) 2008-11-11 2010-05-20 Boehringer Ingelheim International Gmbh Procede de traitement et de prevention de la thrombose utilisant l'etexilate de dabigatran ou un sel de celui-ci avec un profil de securite ameliore par rapport a la therapie de la warfarine classique
CN102050814B (zh) * 2009-11-06 2014-05-28 北京美倍他药物研究有限公司 达比加群的酯衍生物
CN102050815B (zh) * 2009-11-06 2014-04-02 北京美倍他药物研究有限公司 作为前药的达比加群的酯衍生物
US8399678B2 (en) 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
US8981105B2 (en) 2010-07-09 2015-03-17 Esteve Quimica, S.A. Process of preparing a thrombin specific inhibitor
US9006448B2 (en) 2010-12-06 2015-04-14 Msn Laboratories Private Limited Process for the preparation of benzimidazole derivatives and its salts
CN102838588B (zh) * 2011-06-24 2014-03-19 中国药科大学 一类可用于口服的凝血酶抑制剂、其制法以及医药用途
CN102633713B (zh) * 2012-03-22 2013-12-11 南京工业大学 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法
US9273030B2 (en) 2012-04-02 2016-03-01 Msn Laboratories Private Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN102911160B (zh) * 2012-06-29 2014-10-22 上海奥博生物医药技术有限公司 一种制备和纯化达比加群酯中间体的方法
JP2015522596A (ja) * 2012-07-16 2015-08-06 インテルキム、ソシエダッド アノニマ ダビガトランエテキシラートの合成のための中間体を調製する方法及び該中間体の結晶形
WO2014068587A2 (fr) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Procédé amélioré de synthèse du dabigatran et de ses intermédiaires
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
CN102977077A (zh) * 2012-11-28 2013-03-20 浙江燎原药业有限公司 一种达比加群酯中间体的制备方法
CN103224469A (zh) * 2013-05-16 2013-07-31 上海应用技术学院 一种以含氟基团修饰的苯环为中心的达比加群酯类似物及其合成方法
CN103288744A (zh) * 2013-06-04 2013-09-11 上海应用技术学院 一种含氟基团修饰的达比加群酯类似物及其合成方法
CN104418839B (zh) * 2013-08-26 2019-02-01 深圳翰宇药业股份有限公司 达比加群酯的合成方法
CN103710406B (zh) * 2013-12-05 2017-08-11 蚌埠丰原医药科技发展有限公司 一种酶促反应制备达比加群酯主要中间体的方法
CN103772358A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 一种制备达比加群酯的合成方法
CN104003977B (zh) * 2014-06-05 2016-04-13 雅本化学股份有限公司 N-(2-氯甲基-1-甲基-1h-苯并咪唑-5-酰基)-n-(吡啶-2-基) -3-氨基丙酸乙酯的制备方法
CN104045628B (zh) * 2014-06-13 2019-04-09 深圳翰宇药业股份有限公司 苯并咪唑衍生物的纯化方法
CN105315257A (zh) * 2014-06-24 2016-02-10 华仁药业股份有限公司 一种达比加群酯的合成及纯化方法
WO2016000230A1 (fr) 2014-07-03 2016-01-07 上海医药工业研究院 Procédé de préparation d'un intermédiaire d'étexilate de dabigatran et composé intermédiaire
WO2016027077A1 (fr) * 2014-08-18 2016-02-25 Cipla Limited Procédés pour la préparation d'étéxilate de dabigatran et de ses intermédiaires
CN104744438A (zh) * 2014-12-17 2015-07-01 烟台东诚药业集团股份有限公司 一种用于合成制备达比加群酯苯并咪唑中间体的方法
WO2016132296A1 (fr) * 2015-02-18 2016-08-25 Piramal Enterprises Limited Procédé de préparation d'un produit intermédiaire d'étexilate de dabigatran
CN105601615A (zh) * 2015-11-17 2016-05-25 烟台东诚药业集团股份有限公司 一种用于纯化公斤级达比加群酯游离碱的方法
CN105330645B (zh) * 2015-11-30 2020-06-02 常州市阳光药业有限公司 达比加群酯中间体的制备方法
CN106866626A (zh) * 2015-12-14 2017-06-20 天津药物研究院有限公司 一种达比加群酯中间体的制备方法

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JPH02283860A (ja) * 1989-04-24 1990-11-21 Nissan Motor Co Ltd エンジンの点火時期制御装置
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GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
PE121699A1 (es) * 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
US6414008B1 (en) * 1997-04-29 2002-07-02 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
GB0014006D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
DE10230012A1 (de) * 2002-07-04 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 5,6-Dihydro-4H-imidazo[4,5,1-ij]chinoline,ihre Herstellung und ihre Verwendung als Arzneimittel
DE10235639A1 (de) * 2002-08-02 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1609784A1 (fr) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Procédé pour la préparation de 4-(benzimidazolylméthylamino)-benzamidines
US7314033B2 (en) * 2004-11-18 2008-01-01 Massachusetts Institute Of Technology Fuel management system for variable ethanol octane enhancement of gasoline engines
CN100509799C (zh) * 2005-12-16 2009-07-08 复旦大学 一种合成非手性，非肽类的抗凝血酶抑制剂的方法

Also Published As

Publication number Publication date
US8119810B2 (en) 2012-02-21
UA94988C2 (ru) 2011-06-25
DE602008002057D1 (de) 2010-09-16
CA2675624C (fr) 2014-07-08
ZA200906050B (en) 2010-05-26
TWI417291B (zh) 2013-12-01
CA2675624A1 (fr) 2008-08-14
ATE476430T1 (de) 2010-08-15
EA015967B1 (ru) 2012-01-30
ES2349905T3 (es) 2011-01-12
CL2008000355A1 (es) 2008-06-20
JP2010517979A (ja) 2010-05-27
JP5247728B2 (ja) 2013-07-24
AU2008212908B2 (en) 2013-06-20
US20100099882A1 (en) 2010-04-22
UY30888A1 (es) 2008-09-30
SI2118090T1 (sl) 2010-11-30
HRP20100458T1 (hr) 2010-09-30
US20120116089A1 (en) 2012-05-10
CN101600709B (zh) 2012-12-12
DK2118090T3 (da) 2010-11-01
PE20081737A1 (es) 2009-06-20
MY148629A (en) 2013-05-15
MX2009006834A (es) 2009-08-13
EP2118090A1 (fr) 2009-11-18
ECSP099509A (es) 2009-08-28
PT2118090E (pt) 2010-08-31
AR065196A1 (es) 2009-05-20
KR20090116781A (ko) 2009-11-11
BRPI0807197A2 (pt) 2014-06-03
AU2008212908A1 (en) 2008-08-14
EA200901039A1 (ru) 2010-02-26
EP1956018A1 (fr) 2008-08-13
US8455650B2 (en) 2013-06-04
EP2118090B1 (fr) 2010-08-04
PL2118090T3 (pl) 2011-01-31
TW200838860A (en) 2008-10-01
WO2008095928A1 (fr) 2008-08-14
CN101600709A (zh) 2009-12-09
MA31118B1 (fr) 2010-01-04
IL199330A (en) 2013-03-24
CY1111045T1 (el) 2015-06-11
NZ579133A (en) 2010-12-24
HK1136559A1 (en) 2010-07-02

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