[go: up one dir, main page]

TN2009000129A1 - Indole compound - Google Patents

Indole compound

Info

Publication number
TN2009000129A1
TN2009000129A1 TNP2009000129A TN2009000129A TN2009000129A1 TN 2009000129 A1 TN2009000129 A1 TN 2009000129A1 TN P2009000129 A TNP2009000129 A TN P2009000129A TN 2009000129 A TN2009000129 A TN 2009000129A TN 2009000129 A1 TN2009000129 A1 TN 2009000129A1
Authority
TN
Tunisia
Prior art keywords
indole compound
present
glucokinase activator
agent
prodrug
Prior art date
Application number
TNP2009000129A
Other languages
English (en)
Inventor
Tsuneo Yasuma
Osamu Ujikawa
Masahiro Itoh
Kazuko Aoki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39010108&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000129(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of TN2009000129A1 publication Critical patent/TN2009000129A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
TNP2009000129A 2006-10-19 2009-04-08 Indole compound TN2009000129A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006285551 2006-10-19
PCT/JP2007/070772 WO2008050821A1 (fr) 2006-10-19 2007-10-18 Compose indole

Publications (1)

Publication Number Publication Date
TN2009000129A1 true TN2009000129A1 (en) 2010-10-18

Family

ID=39010108

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000129A TN2009000129A1 (en) 2006-10-19 2009-04-08 Indole compound

Country Status (26)

Country Link
US (4) US7652133B2 (fr)
EP (2) EP2074119A1 (fr)
JP (1) JP5260507B2 (fr)
KR (1) KR101444486B1 (fr)
CN (1) CN101573357B (fr)
AU (1) AU2007310064B2 (fr)
BR (1) BRPI0717722A2 (fr)
CA (1) CA2666973C (fr)
CL (1) CL2008001017A1 (fr)
CR (1) CR10748A (fr)
EC (1) ECSP099330A (fr)
GE (1) GEP20115241B (fr)
IL (1) IL198154A (fr)
MA (1) MA30890B1 (fr)
ME (1) MEP11809A (fr)
MX (1) MX2009003972A (fr)
MY (1) MY158052A (fr)
NO (1) NO20091948L (fr)
NZ (1) NZ576570A (fr)
PE (1) PE20090884A1 (fr)
RU (1) RU2454415C9 (fr)
TN (1) TN2009000129A1 (fr)
TW (1) TWI460176B (fr)
UA (1) UA97257C2 (fr)
WO (1) WO2008050821A1 (fr)
ZA (1) ZA200902585B (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2643164T3 (es) * 2007-04-16 2017-11-21 Abbvie Inc. Indol 7-sustituido como inhibidores de Mcl-1
WO2008136428A1 (fr) 2007-04-27 2008-11-13 Takeda Pharmaceutical Company Limited Composé hétérocyclique à cinq chaînons à teneur en azote
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
JP5323834B2 (ja) * 2007-08-17 2013-10-23 エルジー・ライフ・サイエンシーズ・リミテッド 細胞壊死阻害剤としてのインドール化合物
US20100267708A1 (en) * 2007-12-20 2010-10-21 Lg Life Sciences Ltd. Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient
WO2009088192A2 (fr) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. Dérivés d'indole et d'indolazole possédant un effet de conservation de cellules, de tissus et d'organes
WO2009097995A1 (fr) * 2008-02-07 2009-08-13 Sanofi-Aventis Nouvelles imidazolidines substituées par un phényle, procédé de production, médicaments contenant ces composés et leur utilisation
SI2276760T1 (sl) 2008-04-10 2014-05-30 Takeda Pharmaceutical Company Limited Kondenzirane obročne spojine in njihova uporaba
US8349886B2 (en) 2008-04-16 2013-01-08 Takeda Pharmaceutical Company Limited Nitrogenated 5-membered heterocyclic compound
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
JP5597200B2 (ja) * 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムｐ４５０３ａ酵素を検出するための方法
AR073380A1 (es) 2008-09-25 2010-11-03 Takeda Pharmaceutical Composicion farmaceutica solida. comprimido multicapa
EP2351743A4 (fr) 2008-10-27 2012-05-09 Takeda Pharmaceutical Composé bicyclique
EP2371826A4 (fr) 2008-12-29 2012-06-27 Takeda Pharmaceutical Nouveau composé cyclique condensé et utilisation de celui-ci
EP2448921A4 (fr) * 2009-04-09 2013-01-23 Msd Kk Dérivés d'aryl-indole
JP5657578B2 (ja) 2009-06-09 2015-01-21 武田薬品工業株式会社 新規な縮合環化合物およびその用途
EP2460523B1 (fr) 2009-07-28 2017-01-04 Takeda Pharmaceutical Company Limited Comprimé
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
ES2546130T3 (es) 2010-04-27 2015-09-18 Takeda Pharmaceutical Company Limited Derivados de compuestos bicíclicos y su uso como inhibidores de ACC
BR112012032055B8 (pt) 2010-06-16 2019-11-12 Takeda Pharmaceuticals Co cristal de cloridrato de 1-(4-metoxibutil)-n-(2-metilpropil)-n-[(3s,5r)-5-(morfolin-4-ilcarbonil)piperidin-3-il]-1h-benzimidazol-2-carboxamida, medicamento, e, uso do cristal
WO2011159781A2 (fr) * 2010-06-17 2011-12-22 Senomyx, Inc. Modulateurs de goût amer
WO2011157827A1 (fr) 2010-06-18 2011-12-22 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2617726A4 (fr) 2010-09-17 2014-05-14 Takeda Pharmaceutical Agent thérapeutique du diabète
AR084032A1 (es) 2010-11-30 2013-04-17 Takeda Pharmaceutical Compuesto biciclico
MX2013009526A (es) 2011-02-17 2013-10-01 Takeda Pharmaceutical Metodo de produccion de derivado de dihidrobenzofurano opticamente activo.
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2013057944A1 (fr) * 2011-10-19 2013-04-25 興和株式会社 Nouveau composé de spiroindoline, et agent thérapeutique le contenant
CN103998432A (zh) 2011-10-24 2014-08-20 武田药品工业株式会社 双环化合物
JP6129850B2 (ja) 2012-01-12 2017-05-17 武田薬品工業株式会社 Ｍｃｈ受容体拮抗剤としてのベンゾイミダゾール誘導体
EP2816032A4 (fr) 2012-02-13 2015-09-30 Takeda Pharmaceutical Composé à noyaux aromatiques
JP6095580B2 (ja) 2012-02-13 2017-03-15 武田薬品工業株式会社 芳香環化合物
US20150011549A1 (en) 2012-02-15 2015-01-08 Takeda Pharmaceutical Company Limited Tablet
WO2013125732A1 (fr) 2012-02-24 2013-08-29 Takeda Pharmaceutical Company Limited Composé à noyau aromatique
JPWO2013147026A1 (ja) 2012-03-29 2015-12-14 武田薬品工業株式会社 芳香環化合物
CN104379563B (zh) * 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
JPWO2013168759A1 (ja) 2012-05-10 2016-01-07 武田薬品工業株式会社 芳香環化合物
US9505772B2 (en) 2012-05-10 2016-11-29 Takeda Pharmaceutical Company Limited Aromatic ring compound
KR102145641B1 (ko) 2012-06-05 2020-08-18 다케다 야쿠힌 고교 가부시키가이샤 고형 제제
JP2015127299A (ja) 2012-07-19 2015-07-09 武田薬品工業株式会社 固形製剤
WO2014085486A2 (fr) 2012-11-30 2014-06-05 Waters Technologies Corporation Procédés et appareil pour l'analyse de métabolites de la vitamine d
US9605000B2 (en) 2013-03-14 2017-03-28 Takeda Pharmaceutical Company Limited Spiro azetidine isoxazole derivatives and their use as SSTR antagonists
US10005720B2 (en) 2013-04-05 2018-06-26 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
WO2015005489A1 (fr) 2013-07-09 2015-01-15 Takeda Pharmaceutical Company Limited Composé hétérocyclique
ES2672992T3 (es) 2013-08-09 2018-06-19 Takeda Pharmaceutical Company Limited Compuesto aromático
US9868731B2 (en) 2013-08-22 2018-01-16 Lg Chem, Ltd. Indole amide compound as inhibitor of necrosis
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
JOP20180029A1 (ar) 2017-03-30 2019-01-30 Takeda Pharmaceuticals Co مركب حلقي غير متجانس
WO2018181847A1 (fr) 2017-03-31 2018-10-04 武田薬品工業株式会社 Composé aromatique
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
AR111199A1 (es) 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
MY205468A (en) 2018-03-23 2024-10-22 Carmot Therapeutics Inc Modulators of g-protein coupled receptors
US20210403420A1 (en) 2018-08-27 2021-12-30 Scohia Pharma, Inc. Benzoate compound
EP3856768A2 (fr) 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Composés peptidiques agonistes du récepteur du gip et leurs utilisations
JP7511548B2 (ja) 2018-09-24 2024-07-05 武田薬品工業株式会社 Ｇｉｐ受容体アゴニストペプチド化合物及びその使用
CN109250963B (zh) * 2018-09-29 2021-07-16 福建省昊立建设工程有限公司 一种复合增韧混凝土及其制备方法
CR20220371A (es) 2020-02-07 2022-10-27 Gasherbrum Bio Inc Agonistas heterocíclicos de glp-1
WO2021193984A2 (fr) 2020-03-25 2021-09-30 Takeda Pharmaceutical Company Limited Dosage d'une fois par jour de composés peptidiques de l'agoniste du récepteur du gip et leurs utilisations
AR121649A1 (es) 2020-03-25 2022-06-22 Takeda Pharmaceuticals Co Dosificación qw de compuestos peptídicos agonistas del receptor de gip y sus usos
CN113563306B (zh) * 2020-04-28 2022-07-01 新发药业有限公司 一种2-(4-苯氧基苯基)-6-(哌啶-4-)基烟酰胺的制备方法
AU2022272251A1 (en) 2021-05-13 2023-11-16 Carmot Therapeutics Inc. Modulators of g-protein coupled receptors
CN119137124A (zh) 2022-03-09 2024-12-13 加舒布鲁姆生物公司 杂环glp-1激动剂
EP4496797A1 (fr) 2022-03-21 2025-01-29 Gasherbrum Bio, Inc. Dérivés de 5,8-dihydro-1,7-naphtyridine utiles en tant qu'agonistes de glp-1 pour le traitement du diabète
WO2023198140A1 (fr) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Agonistes hétérocycliques de glp-1
WO2024125602A1 (fr) 2022-12-15 2024-06-20 Gasherbrum Bio, Inc. Sels et formes solides d'un composé ayant une activité agoniste de glp-1
WO2024131869A1 (fr) 2022-12-22 2024-06-27 Gasherbrum Bio, Inc. Agonistes hétérocycliques du glp-1
WO2024138048A1 (fr) 2022-12-22 2024-06-27 Gasherbrum Bio, Inc. Agonistes de glp-1 hétérocycliques
WO2024169952A1 (fr) 2023-02-16 2024-08-22 Gasherbrum Bio, Inc. Agonistes hétérocycliques de glp-1
TW202506102A (zh) 2023-06-30 2025-02-16 美商迦舒布魯姆生物有限公司 雜環的glp-1促效劑
WO2025015268A1 (fr) 2023-07-13 2025-01-16 Aconcagua Bio, Inc. Modulateurs de l'activité du récepteur de la calcitonine et/ou du récepteur de l'amyline
TW202519220A (zh) 2023-07-13 2025-05-16 美商雅空嘉閣生物公司 化合物、組合物及方法
WO2025045208A1 (fr) 2023-08-31 2025-03-06 Gasherbrum Bio, Inc. Agonistes de glp-1 à base de hétéroaryl-hétérocycloalkyl
WO2025123039A1 (fr) * 2023-12-08 2025-06-12 Shaman Pharma, LLC Procédé de production de dérivés spiro-oxindole et indoxyl de mitragynine
WO2025137307A1 (fr) 2023-12-20 2025-06-26 Gasherbrum Bio, Inc. Agonistes hétérocycliques de glp-1
WO2025154021A1 (fr) 2024-01-19 2025-07-24 Takeda Pharmaceutical Company Limited Composés peptidiques agonistes du récepteur de gip améliorés et leurs utilisations
WO2025154020A1 (fr) 2024-01-19 2025-07-24 Takeda Pharmaceutical Company Limited Composés peptidiques agonistes du récepteur gip améliorés et leurs utilisations
WO2025171340A1 (fr) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. Traitement d'états associés au récepteur de la calcitonine et/ou de l'amyline

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2656610B1 (fr) 1989-12-29 1992-05-07 Sanofi Sa Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique.
AU683492B2 (en) 1993-09-10 1997-11-13 Eisai R&D Management Co., Ltd. Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives
JP3545461B2 (ja) * 1993-09-10 2004-07-21 エーザイ株式会社 二環式ヘテロ環含有スルホンアミド誘導体
WO1997010224A1 (fr) 1995-09-13 1997-03-20 Takeda Chemical Industries, Ltd. Composes de benzoxazepine, leur production et leur utilisation en tant qu'agent d'abaissement des niveaux de lipides
EA003876B1 (ru) * 1998-02-25 2003-10-30 Дженетикс Инститьют, Ллс Ингибиторы фосфолипазных ферментов
JP4007743B2 (ja) 1999-02-26 2007-11-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害剤
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
GB0003636D0 (en) * 2000-02-16 2000-04-05 Smithkline Beecham Plc Novel compounds
WO2001082925A1 (fr) 2000-04-28 2001-11-08 Takeda Chemical Industries, Ltd. Antagonistes de l'hormone concentrant la melanine
CA2408913A1 (fr) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
EP1549638B1 (fr) * 2002-10-03 2007-10-03 F. Hoffmann-La Roche Ag Indole-3-carboxamides servant d'activateurs de glucokinase (gk)
EP1532980A1 (fr) 2003-11-24 2005-05-25 Novo Nordisk A/S Carboxamides d'indole n-heteroarylé et leurs analogues, utiles comme des activateurs de glucokinase pour le traitement de diabetes
US7498445B2 (en) * 2004-05-05 2009-03-03 Renopharm Ltd. Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
EP1632491A1 (fr) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. composes indole substitues et leur utilisation comme modulateurs du recepteur 5-ht6
CA2605778A1 (fr) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited Compose heterocyclique fusionne
WO2007037543A1 (fr) 2005-09-29 2007-04-05 Banyu Pharmaceutical Co., Ltd. Dérivé de biarylamide
EP1935890B1 (fr) 2005-09-30 2016-03-16 Msd K.K. Dérivé indole substitué en position 2 par un groupe hétéroaryle
PE20090596A1 (es) 2007-08-14 2009-06-07 Bayer Schering Pharma Ag Imidazoles biciclicos fusionados
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
ES2424023T3 (es) 2007-10-18 2013-09-26 Janssen Pharmaceutica N.V. 1,2,4-triazoles trisustituidos
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative

Also Published As

Publication number Publication date
NZ576570A (en) 2010-11-26
TW200825071A (en) 2008-06-16
JP2010506825A (ja) 2010-03-04
UA97257C2 (en) 2012-01-25
KR101444486B1 (ko) 2014-09-24
WO2008050821A1 (fr) 2008-05-02
IL198154A0 (en) 2009-12-24
KR20090068292A (ko) 2009-06-25
MX2009003972A (es) 2009-04-27
CA2666973A1 (fr) 2008-05-02
ME00681B (fr) 2011-12-20
ECSP099330A (es) 2009-06-30
AU2007310064B2 (en) 2013-03-28
US20080096877A1 (en) 2008-04-24
CN101573357A (zh) 2009-11-04
RU2009118602A (ru) 2010-11-27
MY158052A (en) 2016-08-30
TWI460176B (zh) 2014-11-11
EP2508524A2 (fr) 2012-10-10
CL2008001017A1 (es) 2009-04-24
US8410087B2 (en) 2013-04-02
IL198154A (en) 2014-08-31
US20100144702A1 (en) 2010-06-10
MEP11809A (en) 2011-12-20
AU2007310064A1 (en) 2008-05-02
EP2508524A3 (fr) 2012-10-24
RU2454415C9 (ru) 2013-02-27
EP2074119A1 (fr) 2009-07-01
JP5260507B2 (ja) 2013-08-14
RU2454415C2 (ru) 2012-06-27
BRPI0717722A2 (pt) 2013-10-29
US20090286975A1 (en) 2009-11-19
AU2007310064A2 (en) 2009-06-04
ZA200902585B (en) 2010-09-29
US7777047B2 (en) 2010-08-17
US7718798B2 (en) 2010-05-18
CR10748A (es) 2009-05-20
GEP20115241B (en) 2011-06-10
CN101573357B (zh) 2013-01-23
NO20091948L (no) 2009-07-13
MA30890B1 (fr) 2009-11-02
CA2666973C (fr) 2015-03-31
US20100137610A1 (en) 2010-06-03
PE20090884A1 (es) 2009-08-05
US7652133B2 (en) 2010-01-26

Similar Documents

Publication Publication Date Title
TN2009000129A1 (en) Indole compound
JO2681B1 (en) Indole derivatives
MX2010009736A (es) Compuesto heterociclico.
MY152475A (en) Fused ring compounds and use thereof
MX2009007180A (es) Agonistas del receptor acoplado a la proteina g de la piperidina.
MY154798A (en) Fused cyclic compounds
TW200732341A (en) Chemical compounds
TW200833675A (en) Nicotinamide derivatives
UA96152C2 (en) Dihydropyrazolopyrimidinone derivatives
GB0812642D0 (en) Compounds
TW200745067A (en) Novel compounds
MX2009012285A (es) Inhibidores de diacilglicerol aciltransferasa.
MY149648A (en) Carboxylalkylene-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
RS52065B (en) PIPERIDINSKI GPCR AGONIST
WO2009016462A3 (fr) Bicyclolactames substitués
MY148634A (en) Pyridazinone derivatives
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
IL187005A0 (en) Diacylglycerol acyltransferase inhibitors
MX2010009922A (es) Activadores de piridazinona glucocinasa.
MX2010005649A (es) Compuestos novedosos como ligandos del receptor canabinoide y sus usos.
MX2010003440A (es) Compuesto inhibidor de glicogeno fosforilasa y composicion farmaceutica del mismo.
MY158069A (en) Tricyclic compound and pharmaceutical use thereof
MX2010003442A (es) Compuesto inhibidor de fosforilasa de glicogeno y composicion farmaceutica del mismo.
GEP20156222B (en) Pyrazole compound
MX2009013667A (es) Inhibidores triciclicos de hidroxiesteroide deshidrogenasas.