TN2009000142A1 - Bicyclic triazoles as protein kinase modulators - Google Patents

Bicyclic triazoles as protein kinase modulators

Info

Publication number: TN2009000142A1
Authority: TN; Tunisia
Prior art keywords: protein kinase; kinase modulators; bicyclic triazoles; triazoles; bicyclic
Prior art date: 2006-10-23

Application number

TNP2009000142A

Other languages

English (en)

Inventor

Pierre-Yves Bounaud

Christopher Ronald Smith

Elizabeth Anne Jefferson

Original Assignee

Sgx Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-23

Filing date

2009-04-15

Publication date

2010-10-18

2009-04-15 Application filed by Sgx Pharmaceuticals Inc filed Critical Sgx Pharmaceuticals Inc

2010-10-18 Publication of TN2009000142A1 publication Critical patent/TN2009000142A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

TNP2009000142A 2006-10-23 2009-04-15 Bicyclic triazoles as protein kinase modulators TN2009000142A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US86255206P	2006-10-23	2006-10-23
US87030906P	2006-12-15	2006-12-15
US91376607P	2007-04-24	2007-04-24
US95284007P	2007-07-30	2007-07-30
PCT/US2007/081841 WO2008051808A2 (fr)	2006-10-23	2007-10-18	Triazoles bicycliques en tant que modulateurs de protéine kinase

Publications (1)

Publication Number	Publication Date
TN2009000142A1 true TN2009000142A1 (en)	2010-10-18

Family

ID=38956385

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2009000142A TN2009000142A1 (en)	2006-10-23	2009-04-15	Bicyclic triazoles as protein kinase modulators

Country Status (25)

Country	Link
US (1)	US8507489B2 (fr)
EP (1)	EP2084162B1 (fr)
JP (1)	JP5378222B2 (fr)
KR (1)	KR20090071612A (fr)
AR (1)	AR063520A1 (fr)
AU (1)	AU2007309149C1 (fr)
BR (1)	BRPI0717320A2 (fr)
CA (1)	CA2667428A1 (fr)
CO (1)	CO6190620A2 (fr)
CR (1)	CR10803A (fr)
DK (1)	DK2084162T3 (fr)
EA (1)	EA200970403A1 (fr)
ES (1)	ES2393130T3 (fr)
IL (1)	IL197958A0 (fr)
MA (1)	MA30871B1 (fr)
MX (1)	MX2009004059A (fr)
NO (1)	NO20091618L (fr)
NZ (1)	NZ575336A (fr)
PE (1)	PE20080893A1 (fr)
PL (1)	PL2084162T3 (fr)
PT (1)	PT2084162E (fr)
SV (1)	SV2009003235A (fr)
TN (1)	TN2009000142A1 (fr)
TW (1)	TW200835492A (fr)
WO (1)	WO2008051808A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PA8792501A1 (es) *	2007-08-09	2009-04-23	Sanofi Aventis	Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
TWI365185B (en)	2008-07-24	2012-06-01	Lilly Co Eli	Amidophenoxyindazoles useful as inhibitors of c-met
UY32049A (es)	2008-08-14	2010-03-26	Takeda Pharmaceutical	Inhibidores de cmet
EP2165710A1 (fr) *	2008-09-19	2010-03-24	Institut Curie	Récepteur TYRO3 de la tyrosine kinase en tant que cible thérapeutique dans le traitement d'une tumeur de la vessie
JP2012509342A (ja)	2008-11-20	2012-04-19	オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド	置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン
FR2941951B1 (fr) *	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941952B1 (fr) *	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941950B1 (fr) *	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941949B1 (fr) *	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met.
WO2011018454A1 (fr)	2009-08-12	2011-02-17	Novartis Ag	Composés hydrazone hétérocycliques et leurs utilisations pour traiter le cancer et l'inflammation
CA2771432A1 (fr)	2009-08-20	2011-02-24	Novartis Ag	Composes d'oximes heterocycliques
WO2011079804A1 (fr)	2009-12-31	2011-07-07	Hutchison Medipharma Limited	Certaines triazolopyridines et triazolopyrazines, leurs compositions et leurs procedes d'utilisation
WO2011143646A1 (fr)	2010-05-14	2011-11-17	OSI Pharmaceuticals, LLC	Inhibiteurs de kinases bicycliques fusionnés
AR081039A1 (es)	2010-05-14	2012-05-30	Osi Pharmaceuticals Llc	Inhibidores biciclicos fusionados de quinasa
AR085183A1 (es) *	2010-07-30	2013-09-18	Lilly Co Eli	Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
UY33549A (es) *	2010-08-10	2012-01-31	Glaxo Group Ltd	Quinolil aminas como agentes inhibidores de las quinasas
WO2012042421A1 (fr)	2010-09-29	2012-04-05	Pfizer Inc.	Procédé de traitement de la croissance cellulaire anormale
CN102532141A (zh)	2010-12-08	2012-07-04	中国科学院上海药物研究所	[1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
WO2012096929A2 (fr)	2011-01-11	2012-07-19	Sunovion Pharmaceuticals Inc.	Composés hétéroaryles et leurs procédés d'utilisation
WO2012107500A1 (fr)	2011-02-10	2012-08-16	Novartis Ag	Composés de [1, 2, 4] triazolo [4, 3 -b] pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met
CN103459396B (zh) *	2011-02-10	2015-08-19	诺瓦提斯公司	作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物
JP2014513724A (ja)	2011-05-16	2014-06-05	オーエスアイ・ファーマシューティカルズ，エルエルシー	融合二環キナーゼ阻害剤
CN103958509B (zh) *	2011-09-15	2015-12-23	诺华股份有限公司	作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
WO2013038362A1 (fr)	2011-09-15	2013-03-21	Novartis Ag	3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituées en position 6 à activité tyrosine kinase
WO2013151913A1 (fr)	2012-04-03	2013-10-10	Novartis Ag	Combinaisons d'inhibiteurs de tyrosine kinase et leur utilisation
RU2660354C2 (ru)	2012-04-03	2018-07-05	Новартис Аг	Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение
CN103122000B (zh) *	2012-09-03	2013-12-25	中美冠科生物技术（太仓）有限公司	用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
WO2014089904A1 (fr)	2012-12-10	2014-06-19	Abbvie Inc.	Composés triazinones
US20150174034A1 (en)	2013-03-13	2015-06-25	Avon Products, Inc.	Tyrosinase inhibitors
US20150152122A1 (en) *	2013-03-13	2015-06-04	Avon Products, Inc.	Tyrosinase inhibitors
US9364405B2 (en)	2013-03-13	2016-06-14	Avon Products, Inc.	Tyrosinase inhibitors
AR095365A1 (es) *	2013-03-13	2015-10-14	Hoffmann La Roche	Procedimiento para preparar compuestos benzoxazepina
WO2014174478A1 (fr)	2013-04-26	2014-10-30	Novartis Ag	Combinaisons pharmaceutiques d'un inhibiteur de la pkc et d'un inhibiteur du récepteur tyrosine-kinase c-met
US9512121B2 (en)	2013-05-10	2016-12-06	Jiangsu Hansoh Pharmaceutical Co., Ltd.	[1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof
US10301325B2 (en)	2015-09-24	2019-05-28	Shanghai Haiju Biological Technology Co., Ltd.	Quinoline derivative, and pharmaceutical composition, preparation method and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5604091A (en)	1984-03-01	1997-02-18	Microgenics Corporation	Methods for protein binding enzyme complementation
JPS60194443A (ja) *	1984-03-16	1985-10-02	Fuji Photo Film Co Ltd	ハロゲン化銀写真感光材料
EP0228061A3 (fr) *	1985-12-23	1988-12-14	Takeda Chemical Industries, Ltd.	Composés céphem
JPS62228086A (ja) *	1985-12-23	1987-10-06	Takeda Chem Ind Ltd	セフエム化合物
GB9918035D0 (en)	1999-07-30	1999-09-29	Novartis Ag	Organic compounds
WO2002083675A2 (fr) *	2001-04-10	2002-10-24	Merck Sharp & Dohme Limited	Inhibiteurs de l'activite de l'akt
WO2002083139A1 (fr) *	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibiteurs de l'activite d'akt
US20030229453A1 (en)	2002-04-09	2003-12-11	Antonysamy Stephen Suresh	Crystals and structures of PAK4KD kinase PAK4KD
US7268136B2 (en) *	2002-12-18	2007-09-11	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of protein kinases
US7122548B2 (en) *	2003-07-02	2006-10-17	Sugen, Inc.	Triazolotriazine compounds and uses thereof
WO2006015124A2 (fr) *	2004-07-27	2006-02-09	Sgx Pharmaceuticals, Inc.	Modulateurs heterocycliques a cycles fusionnes pour les kinases
SI1784396T1 (sl)	2004-08-26	2011-03-31	Pfizer	S pirazolom substituirane aminoheteroarilne spojine kot zaviralci protein-kinaze
KR100994173B1 (ko)	2004-12-27	2010-11-15	알콘, 인코퍼레이티드	녹내장 및 다른 로 키나아제-매개 질환 치료용아미노피라진 유사체

2007
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/fr not_active Ceased
- 2007-10-18 CA CA002667428A patent/CA2667428A1/fr not_active Abandoned
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko not_active Abandoned
- 2007-10-18 EP EP07844414A patent/EP2084162B1/fr active Active
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP2084162A2 (fr)	2009-08-05
AU2007309149A1 (en)	2008-05-02
WO2008051808A3 (fr)	2008-07-24
AU2007309149C1 (en)	2013-04-04
NZ575336A (en)	2012-04-27
PL2084162T3 (pl)	2013-01-31
EP2084162B1 (fr)	2012-09-12
CA2667428A1 (fr)	2008-05-02
US8507489B2 (en)	2013-08-13
DK2084162T3 (da)	2012-10-01
AR063520A1 (es)	2009-01-28
SV2009003235A (es)	2009-10-15
JP2010507578A (ja)	2010-03-11
BRPI0717320A2 (pt)	2013-10-22
PT2084162E (pt)	2012-10-09
CR10803A (es)	2009-06-16
KR20090071612A (ko)	2009-07-01
WO2008051808A2 (fr)	2008-05-02
NO20091618L (no)	2009-05-22
MX2009004059A (es)	2009-04-27
EA200970403A1 (ru)	2009-10-30
TW200835492A (en)	2008-09-01
AU2007309149B2 (en)	2012-09-06
MA30871B1 (fr)	2009-11-02
US20090258855A1 (en)	2009-10-15
IL197958A0 (en)	2009-12-24
CO6190620A2 (es)	2010-08-19
ES2393130T3 (es)	2012-12-18
PE20080893A1 (es)	2008-08-26
JP5378222B2 (ja)	2013-12-25

Publication	Publication Date	Title
TN2009000142A1 (en)	2010-10-18	Bicyclic triazoles as protein kinase modulators
MX2009012623A (es)	2009-12-11	Moduladores de cinasa heterociclicos.
TW200833692A (en)	2008-08-16	Triazolopyridazine protein kinase modulators
MX2009006706A (es)	2009-07-02	Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
UA104849C2 (uk)	2014-03-25	4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus
TW200745109A (en)	2007-12-16	Pyrrolo-pyridine kinase modulators
NZ630719A (en)	2017-01-27	Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
MX2009010984A (es)	2010-01-15	Moduladores de heterociclo cinasa de anillo fusionado.
MX2009006704A (es)	2009-06-30	Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
GEP20135785B (en)	2013-03-11	Pyrrolopyrimidine compounds as cdk inhibitors
TNSN07027A1 (en)	2008-06-02	Pyrrolo-pyridine kinase modulators
WO2008124849A3 (fr)	2009-01-29	Modulateurs de pyrrolo-pyridine kinase
WO2011115725A3 (fr)	2012-12-27	Composés d'indazole et leurs utilisations
TNSN07028A1 (en)	2008-06-02	Fused ring heterocycle kinase modulators
AU2011338389A8 (en)	2013-07-18	Bicyclic compounds as Pim inhibitors
IN2014DN07384A (fr)	2015-04-24
EA200870048A1 (ru)	2009-02-27	ГЕТЕРОАРИЛ-ЗЕМЕЩЕННЫЕ ПИРРОЛО[2,3-b]ПИРИДИНЫ И ПИРРОЛО[2,3-b]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
IL193479A0 (en)	2009-05-04	Modulators of muscarinic receptors
MX2011006006A (es)	2011-09-08	Compuestos, composicion farmaceutica y metodos para utilizarse en el tratamiento de trastornos metabolicos.
TW200608960A (en)	2006-03-16	3-aminocyclopentanecarboxamides as modulators of chemokine receptors
UA101315C2 (ru)	2013-03-25	СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА КАК ИНГИБИТОРЫ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
TW200608966A (en)	2006-03-16	3-aminocyclopentanecarboxamides as modulators of chemokine receptors
MY164998A (en)	2018-02-28	Isoquinolinone derivatives as nk3 antagonists
TW200734323A (en)	2007-09-16	3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
WO2009126335A3 (fr)	2010-01-14	Composés inhibiteurs d’ant2 et procédés d’utilisation de ceux-ci